ES2012527A6 - Procedimiento de obtencion de benzo(b) piranos y piranopiridinas. - Google Patents

Procedimiento de obtencion de benzo(b) piranos y piranopiridinas.

Info

Publication number
ES2012527A6
ES2012527A6 ES8801527A ES8801527A ES2012527A6 ES 2012527 A6 ES2012527 A6 ES 2012527A6 ES 8801527 A ES8801527 A ES 8801527A ES 8801527 A ES8801527 A ES 8801527A ES 2012527 A6 ES2012527 A6 ES 2012527A6
Authority
ES
Spain
Prior art keywords
treatment
pyranopyridines
pyranes
well
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8801527A
Other languages
English (en)
Inventor
Stefan Blarer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2012527A6 publication Critical patent/ES2012527A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

PROCEDIMIENTO DE OBTENCION DE BENZO(B)PIRANOS Y PIRANOPIRIDINAS, DE FORMULA (I) EN DONDE LOS DISTINTOS RADIALES TIENEN LOS SIGNIFICADOS INDICADOS EN LA DESCRIPCION. COMPRENDE REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III). LOS COMPUESTOS (I) TIENEN APLICACION EN EL TRATAMIENTO DE TRASTORNOS VASCULARES, ASI COMO TAMBIEN EN EL TRATAMIENTO DE LA PERDIDA DE PELO Y DE LA CALVICIE. LOS COMPUESTOS (I) TIENEN ADEMAS UTILIDAD EN EL TRATAMIENTO DEL ASMA Y DE TRASTORNOS OBSTRUCTIVOS DEL SISTEMA RESPIRATORIO.
ES8801527A 1987-05-16 1988-05-16 Procedimiento de obtencion de benzo(b) piranos y piranopiridinas. Expired - Lifetime ES2012527A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3716523 1987-05-16

Publications (1)

Publication Number Publication Date
ES2012527A6 true ES2012527A6 (es) 1990-04-01

Family

ID=6327752

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8801527A Expired - Lifetime ES2012527A6 (es) 1987-05-16 1988-05-16 Procedimiento de obtencion de benzo(b) piranos y piranopiridinas.

Country Status (21)

Country Link
US (1) US5071871A (es)
JP (1) JPS63303977A (es)
KR (1) KR880013915A (es)
AT (1) ATA125188A (es)
AU (1) AU614285B2 (es)
BE (1) BE1002436A3 (es)
CA (1) CA1312866C (es)
CH (1) CH674984A5 (es)
DK (1) DK265188A (es)
ES (1) ES2012527A6 (es)
FI (1) FI882248A (es)
FR (1) FR2615191B1 (es)
GB (1) GB2204868B (es)
HU (1) HU203336B (es)
IL (1) IL86376A0 (es)
IT (1) IT1219940B (es)
NL (1) NL8801258A (es)
NZ (1) NZ224604A (es)
PT (1) PT87492B (es)
SE (1) SE467924B (es)
ZA (1) ZA883450B (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
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DE3835011A1 (de) * 1988-10-14 1990-04-19 Merck Patent Gmbh Chromanderivate
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
AU628331B2 (en) * 1988-05-06 1992-09-17 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
DE3837809A1 (de) * 1988-11-08 1990-05-10 Merck Patent Gmbh Tetralinderivate
FR2639349B1 (fr) * 1988-11-23 1991-02-22 Sanofi Sa Nouveaux derives du chromane actifs sur le systeme nerveux central, leur procede de preparation et les compositions pharmaceutiques en contenant
GB8902118D0 (en) * 1989-02-01 1989-03-22 Beecham Group Plc Chemical process
US5239090A (en) * 1989-02-01 1993-08-24 Beecham Group P.L.C. Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates
US5066816A (en) * 1989-03-03 1991-11-19 Yoshitomi Pharmaceutical Industries, Ltd. Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2h-1-benzopyran compounds and intermediates therefor
US5162553A (en) * 1989-03-03 1992-11-10 Yoshitomi Pharmaceutical Industries, Ltd. Processes for preparing optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compounds and intermediates therefor
US5232938A (en) * 1989-05-24 1993-08-03 Beecham Group P.L.C. Certain 1,2,4-triazole(oxy or amino)benzopyran derivatives having pharmacological activity
GB8911949D0 (en) * 1989-05-24 1989-07-12 Beecham Group Plc Novel compounds
DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
GB8915315D0 (en) * 1989-07-04 1989-08-23 Sandoz Ltd Pharmaceutical compositions for use against hypertension and congestive heart failure
US5223629A (en) * 1989-07-21 1993-06-29 Alkaloida Vegyeszeti Gyar Process for the preparation of anti-hypertensive benzopyran
DE3924417A1 (de) * 1989-07-24 1991-01-31 Merck Patent Gmbh Chromanderivate
DE3926001A1 (de) * 1989-08-05 1991-02-07 Merck Patent Gmbh Chromanderivate
US5232944A (en) * 1989-10-09 1993-08-03 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
DE3933663A1 (de) * 1989-10-09 1991-04-11 Merck Patent Gmbh Chromanderivate
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
DE3936616A1 (de) * 1989-11-03 1991-05-08 Merck Patent Gmbh Verfahren zur enantiomerentrennung von benzopyranderivaten
GB2242628A (en) * 1990-04-06 1991-10-09 Sandoz Ltd Asthma prophylactic use of K+ channel activators
BE1004295A3 (fr) * 1990-05-17 1992-10-27 Sandoz Sa Utilisation des activateurs des canaux potassiques pour la prophylaxie de l'asthme.
DE4038752A1 (de) * 1990-12-05 1992-06-11 Merck Patent Gmbh Chromanderivate
AU1256192A (en) * 1991-02-18 1992-09-15 Chugai Seiyaku Kabushiki Kaisha Hair growth stimulant
US5291890A (en) * 1991-08-29 1994-03-08 General Electric Company Magnetic resonance surgery using heat waves produced with focussed ultrasound
US5206252A (en) * 1992-05-08 1993-04-27 American Home Products Corporation Thiadiazolyl-amino derivatives of benzopyrans and indanes
AU4761693A (en) * 1992-08-17 1994-03-15 Chugai Seiyaku Kabushiki Kaisha Benzopyran and benzoxazine derivatives
KR100330697B1 (ko) * 1993-08-19 2002-10-04 얀센 파마슈티카 엔.브이. 혈관수축성치환된디하이드로피라노피리딘
US5368031A (en) * 1993-08-29 1994-11-29 General Electric Company Magnetic resonance surgery using heat waves produced with a laser fiber
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
KR0170534B1 (ko) * 1993-11-10 1999-02-18 미즈노 시게루 크로만 유도체 및 그의 제약학적 용도
US5482942A (en) * 1994-06-28 1996-01-09 American Home Products Corporation (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
US5470861A (en) * 1994-08-04 1995-11-28 Hoffmann-La Roche Inc. Method of promoting hair growth
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
WO2001021609A1 (en) * 1999-09-24 2001-03-29 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivative
AU7453900A (en) * 1999-10-05 2001-05-10 Nissan Chemical Industries Ltd. 4-oxybenzopyran derivative
WO2010016044A1 (en) * 2008-08-05 2010-02-11 University College Cork, National University Of Ireland, Cork Treatment of retinal degeneration

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4391815A (en) * 1976-04-02 1983-07-05 Beecham Group Limited Cyanobenzano[b]pyrans
FI79535C (fi) * 1982-05-06 1990-01-10 Erba Farmitalia Foerfarande foer framstaellning av dihydrobensopyrans och dihydrobensotiopyrans substituerade iminoderivat.
EP0107423B1 (en) * 1982-10-19 1986-07-23 Beecham Group Plc Novel chromans and chromenes
GB8308062D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8308063D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
EP0205292B1 (en) * 1985-06-08 1991-11-06 Beecham Group Plc Pyrano[3,2-c]pyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
DE3732146A1 (de) * 1987-09-24 1989-04-06 Merck Patent Gmbh Azachromanderivate
AU621578B2 (en) * 1987-12-22 1992-03-19 Suntory Limited Novel compound effective as cerebral insufficiency improver

Also Published As

Publication number Publication date
FR2615191A1 (fr) 1988-11-18
HU203336B (en) 1991-07-29
BE1002436A3 (fr) 1991-02-12
KR880013915A (ko) 1988-12-22
AU614285B2 (en) 1991-08-29
SE8801807D0 (sv) 1988-05-13
FI882248A0 (fi) 1988-05-13
GB2204868B (en) 1991-05-22
ATA125188A (de) 1993-06-15
IT1219940B (it) 1990-05-24
JPS63303977A (ja) 1988-12-12
DK265188D0 (da) 1988-05-13
FR2615191B1 (fr) 1991-01-11
FI882248A (fi) 1988-11-17
SE8801807L (sv) 1988-11-17
US5071871A (en) 1991-12-10
NZ224604A (en) 1991-04-26
HUT50151A (en) 1989-12-28
GB8811359D0 (en) 1988-06-15
IL86376A0 (en) 1988-11-15
ZA883450B (en) 1990-01-31
CA1312866C (en) 1993-01-19
IT8847956A0 (it) 1988-05-13
SE467924B (sv) 1992-10-05
GB2204868A (en) 1988-11-23
PT87492A (pt) 1989-05-31
DK265188A (da) 1988-11-17
NL8801258A (nl) 1988-12-16
AU1615888A (en) 1988-11-17
PT87492B (pt) 1992-09-30
CH674984A5 (es) 1990-08-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000201