HUP0203045A2 - Epesavval képezett 4-benzil-amino-kinolin konjugátumok és hetero-analógjai, valamint eljárás a vegyületek előállítására és a vegyületeket tartalmazó gyógyászati készítmények, és ezek alkalmazása - Google Patents

Epesavval képezett 4-benzil-amino-kinolin konjugátumok és hetero-analógjai, valamint eljárás a vegyületek előállítására és a vegyületeket tartalmazó gyógyászati készítmények, és ezek alkalmazása

Info

Publication number
HUP0203045A2
HUP0203045A2 HU0203045A HUP0203045A HUP0203045A2 HU P0203045 A2 HUP0203045 A2 HU P0203045A2 HU 0203045 A HU0203045 A HU 0203045A HU P0203045 A HUP0203045 A HU P0203045A HU P0203045 A2 HUP0203045 A2 HU P0203045A2
Authority
HU
Hungary
Prior art keywords
compounds
heteroanalogues
methods
formula
benzylaminoquinoline
Prior art date
Application number
HU0203045A
Other languages
English (en)
Inventor
Martin Bickel
Eugen Falk
Armin Hofmeister
Hans-Willi Jansen
Heinz-Werner Kleeman
Original Assignee
Aventis Pharma Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1999145385 external-priority patent/DE19945385A1/de
Priority claimed from DE2000128193 external-priority patent/DE10028193A1/de
Application filed by Aventis Pharma Deutschland Gmbh. filed Critical Aventis Pharma Deutschland Gmbh.
Publication of HUP0203045A2 publication Critical patent/HUP0203045A2/hu
Publication of HUP0203045A3 publication Critical patent/HUP0203045A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A találmány tárgya (I) általános képletű szubsztituált 4-benzil-amino-kinolinok. A csoportok jelentése az alábbiakban megadott. Kiterjed atalálmány a heteroanalógokra, gyógyászatilag elfogadható sókra ésfiziológiailag funkciós származékokra is. A találmány kiterjed azilyen vegyületek előállítását szolgáló eljárásokra is, és avegyületeket pl. gyógyszerként alkalmazhatjuk epekövek kezelésére vagymegelőzésére, továbbá a találmány kiterjed a vegyületeket tartalmazógyógyszerkészítményekre. Az (I) általános képletben G jelentése Gképletű csoport, P jelentése P vagy P' képletű csoport L jelentése 1-15 szénatomos alkilcsoport, ahol egy vagy több metilénegységethelyettesíthet -CH=CH-, -C=C-, -NR(11)-, CO-, -O-, -SO2- vagy -S-. Atovábbi szubsztituensek jelentése a leírásban megadott. Ó
HU0203045A 1999-09-22 2000-09-06 4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use HUP0203045A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1999145385 DE19945385A1 (de) 1999-09-22 1999-09-22 Substituierte 4-Benzylaminochinoline und ihre Heteroanlagen, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE2000128193 DE10028193A1 (de) 2000-06-09 2000-06-09 Substituierte 4-Benzylamminochinoline und ihre Heteroanalogen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikamente oder Diagnostika, sowie sie enthaltende Medikamente
PCT/EP2000/008691 WO2001021642A1 (de) 1999-09-22 2000-09-06 4-benzylaminochinoline konjugaten mit gallensaeure und ihre heteroanalogen, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und deren anwendung

Publications (2)

Publication Number Publication Date
HUP0203045A2 true HUP0203045A2 (hu) 2003-01-28
HUP0203045A3 HUP0203045A3 (en) 2004-06-28

Family

ID=26005994

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0203045A HUP0203045A3 (en) 1999-09-22 2000-09-06 4-benzylaminoquinoline conjugates with bile acid and their heteroanalogues, methods for producing the same, medicaments containing these compounds and their use

Country Status (26)

Country Link
US (1) US6339077B1 (hu)
EP (1) EP1218401B1 (hu)
JP (1) JP4833471B2 (hu)
KR (1) KR20030010575A (hu)
CN (1) CN1158299C (hu)
AT (1) ATE269352T1 (hu)
AU (1) AU779412B2 (hu)
BR (1) BR0014233A (hu)
CA (1) CA2385445A1 (hu)
CZ (1) CZ2002992A3 (hu)
DE (1) DE50006842D1 (hu)
DK (1) DK1218401T3 (hu)
EE (1) EE200200143A (hu)
ES (1) ES2218222T3 (hu)
HK (1) HK1049169B (hu)
HR (1) HRP20020238A2 (hu)
HU (1) HUP0203045A3 (hu)
IL (1) IL148739A0 (hu)
NO (1) NO20021337L (hu)
NZ (1) NZ517899A (hu)
PL (1) PL353992A1 (hu)
PT (1) PT1218401E (hu)
RU (1) RU2247125C2 (hu)
SK (1) SK3862002A3 (hu)
WO (1) WO2001021642A1 (hu)
YU (1) YU19302A (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576644B2 (en) 2000-09-06 2003-06-10 Bristol-Myers Squibb Co. Quinoline inhibitors of cGMP phosphodiesterase
ITMI20021025A1 (it) * 2002-05-14 2003-11-14 Nicox Sa Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale
CZ301037B6 (cs) * 2007-09-06 2009-10-21 Vysoká škola chemicko-technologická v Praze Amidové konjugáty steroidních a žlucových kyselin s D-glukosaminem a zpusob jejich prípravy
SG174211A1 (en) * 2009-03-24 2011-10-28 Abbott Lab Process for preparing antiviral compound
RU2605549C2 (ru) * 2010-04-02 2016-12-20 Синомикс, Инк. Производные 3-карбокси-4-аминохинолина, полезные как модификаторы сладкого вкуса
EP2742026B1 (en) 2011-08-12 2016-10-05 Senomyx, Inc. Sweet flavor modifier
MX2017005931A (es) 2014-11-07 2017-06-30 Senomyx Inc Acidos 4-amino-5- (ciclohexiloxi) quinolina-3-carboxilicos sustituidos como modificadores del sabor dulce.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
JPH0667846B2 (ja) * 1989-04-28 1994-08-31 一 滝川 利胆剤
TW289021B (hu) * 1993-05-08 1996-10-21 Hoechst Ag
IT1274000B (it) * 1994-04-06 1997-07-14 Alfa Wassermann Spa Derivati di acidi biliari utili nella terapia della calcolosi biliare da colesterolo e nelle patologie indotte da colestasi
DE4432708A1 (de) 1994-09-14 1996-03-21 Hoechst Ag Modifizierte Gallensäuren, Verfahren zu ihrer Herstellung und ihre Verwendung
JPH09315979A (ja) * 1996-05-24 1997-12-09 Tokyo Tanabe Co Ltd 利胆剤
AU7552198A (en) * 1997-06-11 1998-12-30 Sankyo Company Limited Benzylamine derivatives

Also Published As

Publication number Publication date
JP2003510255A (ja) 2003-03-18
HUP0203045A3 (en) 2004-06-28
HK1049169B (zh) 2005-04-22
EP1218401A1 (de) 2002-07-03
JP4833471B2 (ja) 2011-12-07
RU2247125C2 (ru) 2005-02-27
AU7515600A (en) 2001-04-24
KR20030010575A (ko) 2003-02-05
ES2218222T3 (es) 2004-11-16
DE50006842D1 (de) 2004-07-22
ATE269352T1 (de) 2004-07-15
US6339077B1 (en) 2002-01-15
HRP20020238A2 (en) 2004-04-30
IL148739A0 (en) 2002-09-12
CN1158299C (zh) 2004-07-21
EP1218401B1 (de) 2004-06-16
AU779412B2 (en) 2005-01-20
BR0014233A (pt) 2002-05-21
YU19302A (sh) 2004-11-25
CZ2002992A3 (cs) 2002-06-12
WO2001021642A1 (de) 2001-03-29
DK1218401T3 (da) 2004-10-04
CA2385445A1 (en) 2001-03-29
HK1049169A1 (en) 2003-05-02
NO20021337D0 (no) 2002-03-18
PL353992A1 (en) 2003-12-15
NZ517899A (en) 2004-03-26
NO20021337L (no) 2002-05-15
PT1218401E (pt) 2004-10-29
SK3862002A3 (en) 2003-01-09
EE200200143A (et) 2003-04-15
CN1374968A (zh) 2002-10-16

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