KR880009975A - 화합물 - Google Patents

화합물 Download PDF

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Publication number
KR880009975A
KR880009975A KR1019880002074A KR880002074A KR880009975A KR 880009975 A KR880009975 A KR 880009975A KR 1019880002074 A KR1019880002074 A KR 1019880002074A KR 880002074 A KR880002074 A KR 880002074A KR 880009975 A KR880009975 A KR 880009975A
Authority
KR
South Korea
Prior art keywords
calcium
compound
pyrano
dioxo
quinoline
Prior art date
Application number
KR1019880002074A
Other languages
English (en)
Inventor
아놀드 내심 마이클
안토니 라파엘 리차드
Original Assignee
에프.머피
피존스 피엘시
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에프.머피, 피존스 피엘시 filed Critical 에프.머피
Publication of KR880009975A publication Critical patent/KR880009975A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals

Abstract

내용 없음.

Description

화 합 물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 칼슘 9-에틸-6,9-디히드로-4,6-디옥소-10-프로필-4H-피라노[3,2-g]퀴놀린-2,8-디카르복실레이트.
  2. 제1항에 있어서, 물 함량이 12 내지 25% W/W인 화합물.
  3. 상기 전 항 중 어느 하나의 항에 있어서, 제약상 허용되는 보조제, 희석제 또는 담체와 혼합된 화합물.
  4. 제1항에 의한 화합물의 가역성 기도 폐쇄증 치료용 의약품 제조 용도.
  5. 제1항에 의한 화합물의 비염의 예방 또는 치료용 의약품 제조 용도.
  6. 제1항에 있어서, 제약상 허용되는 보조제, 희석제 또는 담체와 혼합해서 흡입 투여하기 위한 분말제 형태의 화합물.
  7. 제1항에 있어서, 약화 포사제와 혼합된 압축 에어로졸제 형태의 화합물.
  8. 네도크로밀 칼슘이 5% W/W 미만의 물 함량을 갖는 제7항에 의한 에어로졸제.
  9. a) 9-에틸-6,9-디히드로-4,6-디옥소-10-프로필-4H-피라노[3,2-g]퀴놀린-2,8-디카르복실산의 적합한 염 용액과 이용 가능한 형태의 칼슘 양이온을 함유하는 적합한 용액과 반응시키거나, 또는 b)9-에틸-6,9-디히드로-4,6-디옥소-10-프로필-4H-피라노[3,2-g]퀴놀린-2,8-디카르복실산 또는 그의 적합한 에스테르 또는 아미드를 이용 가능한 형태의 칼슘 양이온을 함유하는 염기와 반응시키는 것으로 되는 네도크로밀 칼슘의 제조방법.
    ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019880002074A 1987-02-28 1988-02-27 화합물 KR880009975A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB87/04773 1987-02-28
GB878704773A GB8704773D0 (en) 1987-02-28 1987-02-28 Compounds

Publications (1)

Publication Number Publication Date
KR880009975A true KR880009975A (ko) 1988-10-06

Family

ID=10613143

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880002074A KR880009975A (ko) 1987-02-28 1988-02-27 화합물

Country Status (23)

Country Link
US (1) US4849427A (ko)
EP (1) EP0285246B1 (ko)
JP (1) JPS63225380A (ko)
KR (1) KR880009975A (ko)
AT (1) ATE71099T1 (ko)
AU (1) AU597795B2 (ko)
DE (1) DE3867281D1 (ko)
DK (1) DK102788A (ko)
ES (1) ES2038750T3 (ko)
FI (1) FI87566C (ko)
GB (1) GB8704773D0 (ko)
GR (1) GR3003709T3 (ko)
HU (1) HU199477B (ko)
IL (1) IL85559A (ko)
MX (1) MX10554A (ko)
MY (1) MY103216A (ko)
NO (1) NO166282C (ko)
NZ (1) NZ223646A (ko)
PH (1) PH24496A (ko)
PT (1) PT86859B (ko)
WO (1) WO1990002128A1 (ko)
YU (2) YU37988A (ko)
ZA (1) ZA881343B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
EP0279121B1 (en) * 1986-12-23 1993-09-01 FISONS plc Pharmaceutical compositions comprising an aqueous solution of a pyranoquinoline derivative
USRE38628E1 (en) * 1986-12-23 2004-10-19 Fisons Plc Pharmaceutical compositions
GB8704773D0 (en) * 1987-02-28 1987-04-01 Fisons Plc Compounds
GB8820267D0 (en) * 1988-08-26 1988-09-28 Fisons Plc Pharmaceutical formulation
US5248493A (en) * 1988-08-27 1993-09-28 Fisons Plc Pharmaceutical composition
US5198221A (en) * 1989-05-17 1993-03-30 Fisons Plc Pharmaceutical composition
GB8921222D0 (en) * 1989-09-20 1989-11-08 Riker Laboratories Inc Medicinal aerosol formulations
GB9323132D0 (en) * 1993-11-10 1994-01-05 Fisons Plc New pharmaceutical use
US20050026880A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a cromone for treatment of asthma or chronic obstructive pulmonary disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA782473B (en) * 1977-05-04 1979-04-25 Fisons Ltd Benzo pyrano-quinolinones
US4471119A (en) * 1981-10-10 1984-09-11 Fisons Plc Certain hydrolysis or reductive cleavage reaction involving 4h-pyrano(3,2-g) quinoline-2,8-dicarboxylic acid derivatives
DE3571439D1 (en) * 1984-01-26 1989-08-17 Fisons Plc Benzopyran derivatives, compositions containing them and processes for their preparation
DE3411319C2 (de) * 1984-03-28 1986-12-04 Boehringer Ingelheim KG, 6507 Ingelheim Verwendung von Citronensäureestern als Treib- und/oder Nucleierungsmittel zur Herstellung thermoplastischer Kunststoffschäume
DE3584580D1 (de) * 1984-04-13 1991-12-12 Fisons Plc Formen und formulierungen des nedocromil-natriumsalzes.
EP0279121B1 (en) * 1986-12-23 1993-09-01 FISONS plc Pharmaceutical compositions comprising an aqueous solution of a pyranoquinoline derivative
GB8704773D0 (en) * 1987-02-28 1987-04-01 Fisons Plc Compounds

Also Published As

Publication number Publication date
FI87566C (fi) 1993-01-25
NO880845L (no) 1988-08-29
PH24496A (en) 1990-07-18
NZ223646A (en) 1990-05-28
DK102788D0 (da) 1988-02-26
US4849427A (en) 1989-07-18
NO880845D0 (no) 1988-02-26
WO1990002128A1 (en) 1990-03-08
IL85559A (en) 1991-11-21
HUT47581A (en) 1989-03-28
ATE71099T1 (de) 1992-01-15
DE3867281D1 (de) 1992-02-13
MY103216A (en) 1993-05-29
EP0285246A1 (en) 1988-10-05
ZA881343B (en) 1989-01-25
HU199477B (en) 1990-02-28
FI880900A (fi) 1988-08-29
YU37988A (en) 1989-12-31
NO166282B (no) 1991-03-18
PT86859A (pt) 1988-03-01
FI880900A0 (fi) 1988-02-26
JPS63225380A (ja) 1988-09-20
DK102788A (da) 1988-08-29
YU130089A (en) 1991-02-28
FI87566B (fi) 1992-10-15
GB8704773D0 (en) 1987-04-01
AU1214288A (en) 1988-09-01
AU597795B2 (en) 1990-06-07
MX10554A (es) 1993-04-01
GR3003709T3 (ko) 1993-03-16
NO166282C (no) 1991-06-26
PT86859B (pt) 1992-05-29
EP0285246B1 (en) 1992-01-02
IL85559A0 (en) 1988-08-31
ES2038750T3 (es) 1993-08-01

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Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application