BR0008978A - Método para preparação de 5-cianoftalida - Google Patents

Método para preparação de 5-cianoftalida

Info

Publication number
BR0008978A
BR0008978A BR0008978-8A BR0008978A BR0008978A BR 0008978 A BR0008978 A BR 0008978A BR 0008978 A BR0008978 A BR 0008978A BR 0008978 A BR0008978 A BR 0008978A
Authority
BR
Brazil
Prior art keywords
cyanophthalide
preparing
preparation
sulfonamide
cyanophtalide
Prior art date
Application number
BR0008978-8A
Other languages
English (en)
Inventor
Beat Weber
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of BR0008978A publication Critical patent/BR0008978A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Abstract

"MéTODO PARA PREPARAçãO DE 5-CIANOFTALIDA".Provê-se um método para a preparação de 5-cianoftalida, no qual5-carboxiftalida é reagido com um agente de desidratação, talcomo tionilcloreto e sulfonamida, preferivelmente sulfonamida.Cianoftalida é preparado em rendimentos altos através de umprocedimento conveniente. 5-cianoftalida é um intermediárioutilizado na preparação do medicamento antidepressivo citalopram.
BR0008978-8A 1999-01-29 2000-01-26 Método para preparação de 5-cianoftalida BR0008978A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199900128 1999-01-29
PCT/DK2000/000032 WO2000044738A1 (en) 1999-01-29 2000-01-26 Method for the preparation of 5-cyanophthalide

Publications (1)

Publication Number Publication Date
BR0008978A true BR0008978A (pt) 2001-11-27

Family

ID=8090069

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0008978-8A BR0008978A (pt) 1999-01-29 2000-01-26 Método para preparação de 5-cianoftalida

Country Status (31)

Country Link
US (1) US6441201B1 (pt)
EP (1) EP1150966B1 (pt)
JP (1) JP2002535397A (pt)
KR (1) KR100430327B1 (pt)
CN (1) CN1158271C (pt)
AR (1) AR022329A1 (pt)
AT (1) ATE222900T1 (pt)
AU (1) AU763666B2 (pt)
BG (1) BG64924B1 (pt)
BR (1) BR0008978A (pt)
CA (1) CA2361395C (pt)
CZ (1) CZ300257B6 (pt)
DE (1) DE60000364T2 (pt)
DK (1) DK1150966T3 (pt)
EA (1) EA003257B1 (pt)
ES (1) ES2180508T3 (pt)
HK (1) HK1044342B (pt)
HU (1) HUP0104976A3 (pt)
IL (2) IL144114A0 (pt)
IS (1) IS2223B (pt)
IT (1) IT1317741B1 (pt)
NO (1) NO326532B1 (pt)
NZ (1) NZ512775A (pt)
PL (1) PL198385B1 (pt)
PT (1) PT1150966E (pt)
SI (1) SI1150966T1 (pt)
SK (1) SK284367B6 (pt)
TR (1) TR200102135T2 (pt)
UA (1) UA70987C2 (pt)
WO (1) WO2000044738A1 (pt)
ZA (1) ZA200105549B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
TR200401456T1 (tr) 1999-10-25 2005-04-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem.
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
AU778751B2 (en) 1999-12-28 2004-12-16 H. Lundbeck A/S Method for the preparation of citalopram
ATE253568T1 (de) 1999-12-30 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO2001051477A1 (en) 2000-01-14 2001-07-19 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PL360110A1 (en) 2000-03-13 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PL360107A1 (en) 2000-03-14 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
CZ20023406A3 (cs) * 2000-03-16 2003-01-15 H. Lundbeck A/S Způsob výroby 5-kyano-1-(4-fluorfenyl)-1,3-dihydroisobenzofuranu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) * 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
CA2360303C (en) 2000-12-22 2003-08-12 Marco Villa Process for the preparation of pure citalopram
EP1181272B1 (en) 2000-12-28 2002-08-28 H. Lundbeck A/S Process for the preparation of pure citalopram
GR1004635B (el) * 2001-08-14 2004-07-14 H@Αlundbeckαa@Sαα Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα
EP1321464A1 (en) * 2001-12-21 2003-06-25 ICROM S.p.A. Process for the preparation of 5-cyanophthalide and intermediates useful therein
PE20040991A1 (es) 2002-08-12 2004-12-27 Lundbeck & Co As H Separacion de intermediarios para la preparacion de escitalopram
CA2519629A1 (en) 2003-03-21 2004-09-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (pt) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
DK1015416T3 (da) * 1997-07-08 2001-11-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
JP3813820B2 (ja) 1997-11-11 2006-08-23 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
EA002977B1 (ru) 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
PT1140886E (pt) * 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
CA2360303C (en) 2000-12-22 2003-08-12 Marco Villa Process for the preparation of pure citalopram
EP1181272B1 (en) 2000-12-28 2002-08-28 H. Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
PL349908A1 (en) 2002-10-07
AR022329A1 (es) 2002-09-04
NO326532B1 (no) 2008-12-29
IL144114A0 (en) 2002-05-23
CN1337957A (zh) 2002-02-27
HUP0104976A2 (en) 2002-06-29
PT1150966E (pt) 2003-01-31
NO20013667L (no) 2001-07-26
BG64924B1 (bg) 2006-09-29
IS5982A (is) 2001-06-28
JP2002535397A (ja) 2002-10-22
WO2000044738A1 (en) 2000-08-03
IL144114A (en) 2006-06-11
CZ300257B6 (cs) 2009-04-01
TR200102135T2 (tr) 2002-01-21
HK1044342B (zh) 2005-04-22
PL198385B1 (pl) 2008-06-30
BG105692A (en) 2002-02-28
US6441201B1 (en) 2002-08-27
NO20013667D0 (no) 2001-07-26
SK10562001A3 (sk) 2002-01-07
ITMI20000112A1 (it) 2001-07-27
EA003257B1 (ru) 2003-02-27
SI1150966T1 (en) 2003-02-28
ES2180508T3 (es) 2003-02-16
KR20010101432A (ko) 2001-11-14
DE60000364T2 (de) 2003-04-03
CN1158271C (zh) 2004-07-21
HUP0104976A3 (en) 2002-09-30
ZA200105549B (en) 2002-07-05
AU2278200A (en) 2000-08-18
IS2223B (is) 2007-03-15
HK1044342A1 (en) 2002-10-18
EA200100834A1 (ru) 2001-12-24
UA70987C2 (uk) 2004-11-15
ATE222900T1 (de) 2002-09-15
SK284367B6 (sk) 2005-02-04
DE60000364D1 (de) 2002-10-02
US20020028956A1 (en) 2002-03-07
KR100430327B1 (ko) 2004-05-03
AU763666B2 (en) 2003-07-31
IT1317741B1 (it) 2003-07-15
CA2361395A1 (en) 2000-08-03
CZ20012734A3 (cs) 2002-01-16
CA2361395C (en) 2005-11-15
ITMI20000112A0 (it) 2000-01-27
EP1150966A1 (en) 2001-11-07
EP1150966B1 (en) 2002-08-28
DK1150966T3 (da) 2002-12-30
NZ512775A (en) 2003-11-28

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE(S).

B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time