ES2180508T3 - Metodo para la preparacion de 5-cianoftalida. - Google Patents

Metodo para la preparacion de 5-cianoftalida.

Info

Publication number
ES2180508T3
ES2180508T3 ES00901482T ES00901482T ES2180508T3 ES 2180508 T3 ES2180508 T3 ES 2180508T3 ES 00901482 T ES00901482 T ES 00901482T ES 00901482 T ES00901482 T ES 00901482T ES 2180508 T3 ES2180508 T3 ES 2180508T3
Authority
ES
Spain
Prior art keywords
formula
preparation
amino
phenyloxy
cyanoftalide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00901482T
Other languages
English (en)
Inventor
Beat Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of ES2180508T3 publication Critical patent/ES2180508T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Un método para la preparación de 5-ciano- ftalida **(Ver fórmula IV)** que comprende hacer reaccionar 5-carboxiftalida **(Ver fórmula III)** con un agente deshidratante y una sulfonamida de la fórmula H2N-SO2-R (Fórmula V), en la que R es: a) NH2, alquil(C1-C6)oxi, feniloxi, b) feniloxi sustituido con halógeno, alquilo C1- C4, ciano, hidroxi, alcoxi C1-C4, trifluorometilo, nitro, amino, alquilamino C1-C4 o di-alquil(C1-C4)amino, o c) fenilo sustituido con uno o más sustituyentes aceptores de electrones.
ES00901482T 1999-01-29 2000-01-26 Metodo para la preparacion de 5-cianoftalida. Expired - Lifetime ES2180508T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA199900128 1999-01-29

Publications (1)

Publication Number Publication Date
ES2180508T3 true ES2180508T3 (es) 2003-02-16

Family

ID=8090069

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00901482T Expired - Lifetime ES2180508T3 (es) 1999-01-29 2000-01-26 Metodo para la preparacion de 5-cianoftalida.

Country Status (31)

Country Link
US (1) US6441201B1 (es)
EP (1) EP1150966B1 (es)
JP (1) JP2002535397A (es)
KR (1) KR100430327B1 (es)
CN (1) CN1158271C (es)
AR (1) AR022329A1 (es)
AT (1) ATE222900T1 (es)
AU (1) AU763666B2 (es)
BG (1) BG64924B1 (es)
BR (1) BR0008978A (es)
CA (1) CA2361395C (es)
CZ (1) CZ300257B6 (es)
DE (1) DE60000364T2 (es)
DK (1) DK1150966T3 (es)
EA (1) EA003257B1 (es)
ES (1) ES2180508T3 (es)
HK (1) HK1044342B (es)
HU (1) HUP0104976A3 (es)
IL (2) IL144114A0 (es)
IS (1) IS2223B (es)
IT (1) IT1317741B1 (es)
NO (1) NO326532B1 (es)
NZ (1) NZ512775A (es)
PL (1) PL198385B1 (es)
PT (1) PT1150966E (es)
SI (1) SI1150966T1 (es)
SK (1) SK284367B6 (es)
TR (1) TR200102135T2 (es)
UA (1) UA70987C2 (es)
WO (1) WO2000044738A1 (es)
ZA (1) ZA200105549B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL142346A0 (en) 1998-10-20 2002-03-10 Lundbeck & Co As H Method for the preparation of citalopram
CZ300408B6 (cs) 1998-12-23 2009-05-13 H. Lundbeck A/S Zpusob výroby 5-kyanoftalidu
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
DK1298124T3 (da) 1999-10-25 2007-07-09 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
IL150335A0 (en) 1999-12-28 2002-12-01 Lundbeck & Co As H Method for the preparation of citalopram
PT1246813E (pt) 1999-12-30 2004-02-27 Lundbeck & Co As H Metodo para a preparacao de citalopram
KR100660802B1 (ko) 2000-01-14 2006-12-26 하. 룬트벡 아크티에 셀스카브 5-시아노프탈리드의 제조 방법
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
HUP0300274A2 (hu) 2000-03-13 2003-06-28 H. Lundbeck A/S Eljárás citalopram előállítására
PL360107A1 (en) 2000-03-14 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
ES2159271B1 (es) * 2000-03-16 2002-05-01 Lundbeck & Co As H Metodo para la preparacion de 5-ciano-1-(4-fluorofenil)-1,3-dihidroisobenzofuranos
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) * 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
KR100439329B1 (ko) 2000-12-22 2004-07-07 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
PL353369A1 (en) 2000-12-28 2003-11-17 H.Lundbeck A/S Process for the preparation of pure citalopram
GR1004635B (el) * 2001-08-14 2004-07-14 H@Αlundbeckαa@Sαα Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα
EP1321464A1 (en) * 2001-12-21 2003-06-25 ICROM S.p.A. Process for the preparation of 5-cyanophthalide and intermediates useful therein
AR040970A1 (es) 2002-08-12 2005-04-27 Lundbeck & Co As H Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
WO2004083197A2 (en) 2003-03-21 2004-09-30 H. Lundbeck A/S Intermediates for the preparation of citalopram and escitalopram
TR200504022T1 (tr) * 2003-03-24 2006-08-21 Hetero Drugs Limited (S)-sitalopram oksalatın yeni sıvı kristal formları.
EP1777221A1 (en) * 2005-10-14 2007-04-25 Adorkem Technology SpA Process for the preparation of 5-cyanophthalide starting from 5-carboxyphthalide

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143703A (es) 1965-03-18
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) * 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
CA2291067C (en) * 1997-07-08 2002-07-30 H. Lundbeck A/S Method for the preparation of citalopram
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
WO1998019512A2 (en) 1997-11-11 1998-05-14 H. Lundbeck A/S Method for the preparation of citalopram
IL142346A0 (en) 1998-10-20 2002-03-10 Lundbeck & Co As H Method for the preparation of citalopram
CZ300408B6 (cs) * 1998-12-23 2009-05-13 H. Lundbeck A/S Zpusob výroby 5-kyanoftalidu
TR200102957T2 (tr) 1999-04-14 2004-12-21 H. Lundbeck A/S Sitalopram hazırlanması için metod.
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
AU742554B2 (en) 1999-10-25 2002-01-03 H. Lundbeck A/S Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
NL1017415C1 (nl) 2000-02-24 2001-05-18 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
KR100439329B1 (ko) 2000-12-22 2004-07-07 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
PL353369A1 (en) 2000-12-28 2003-11-17 H.Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
CA2361395C (en) 2005-11-15
EA200100834A1 (ru) 2001-12-24
KR20010101432A (ko) 2001-11-14
BG64924B1 (bg) 2006-09-29
EA003257B1 (ru) 2003-02-27
CN1158271C (zh) 2004-07-21
US20020028956A1 (en) 2002-03-07
HK1044342A1 (en) 2002-10-18
HUP0104976A3 (en) 2002-09-30
BR0008978A (pt) 2001-11-27
UA70987C2 (uk) 2004-11-15
PL349908A1 (en) 2002-10-07
PL198385B1 (pl) 2008-06-30
IT1317741B1 (it) 2003-07-15
DE60000364D1 (de) 2002-10-02
SK10562001A3 (sk) 2002-01-07
JP2002535397A (ja) 2002-10-22
NO20013667D0 (no) 2001-07-26
ITMI20000112A0 (it) 2000-01-27
NO326532B1 (no) 2008-12-29
AU763666B2 (en) 2003-07-31
BG105692A (en) 2002-02-28
EP1150966A1 (en) 2001-11-07
CN1337957A (zh) 2002-02-27
WO2000044738A1 (en) 2000-08-03
NZ512775A (en) 2003-11-28
SK284367B6 (sk) 2005-02-04
KR100430327B1 (ko) 2004-05-03
ITMI20000112A1 (it) 2001-07-27
ZA200105549B (en) 2002-07-05
EP1150966B1 (en) 2002-08-28
CA2361395A1 (en) 2000-08-03
IL144114A0 (en) 2002-05-23
IL144114A (en) 2006-06-11
TR200102135T2 (tr) 2002-01-21
HK1044342B (zh) 2005-04-22
DK1150966T3 (da) 2002-12-30
HUP0104976A2 (en) 2002-06-29
CZ300257B6 (cs) 2009-04-01
AU2278200A (en) 2000-08-18
DE60000364T2 (de) 2003-04-03
IS2223B (is) 2007-03-15
AR022329A1 (es) 2002-09-04
SI1150966T1 (en) 2003-02-28
CZ20012734A3 (cs) 2002-01-16
PT1150966E (pt) 2003-01-31
IS5982A (is) 2001-06-28
US6441201B1 (en) 2002-08-27
NO20013667L (no) 2001-07-26
ATE222900T1 (de) 2002-09-15

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