JPS5479269A - Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide - Google Patents

Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide

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Publication number
JPS5479269A
JPS5479269A JP14324877A JP14324877A JPS5479269A JP S5479269 A JPS5479269 A JP S5479269A JP 14324877 A JP14324877 A JP 14324877A JP 14324877 A JP14324877 A JP 14324877A JP S5479269 A JPS5479269 A JP S5479269A
Authority
JP
Japan
Prior art keywords
optically active
pyrrolidinecarboxy
anilide
oxo
parts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14324877A
Other languages
Japanese (ja)
Inventor
Shinobu Iriuchijima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP14324877A priority Critical patent/JPS5479269A/en
Publication of JPS5479269A publication Critical patent/JPS5479269A/en
Pending legal-status Critical Current

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  • Pyrrole Compounds (AREA)

Abstract

PURPOSE: To obtain the title compound of optical purity useful as an intermediate for d-2-(anilinomethyl)pyrrolidine, etc. which becomes a highly selective asymmetric reducing reagent, by reacting optically active glutamic acid with a specific amount or more of aniline.
CONSTITUTION: One part by wt. of optically active d-orl-glutamic acid is reacted with 5 parts by wt. or more, preferably 5.5 parts by wt. or more, more preferably 7.5 parts by wt. of aniline to form optically pure d-orl -5-oxo-2-pyrrolidinecarboxy anilide. USE;When used together with lithium aluminum hydride, the compound becomes a highly selective asymmetric reducing reagent. For example, l-phenethyl alcohol of high optical purity can be obtained by reducing acetophenone with d-2-(anilino methyl) pyrrolidine and lithium aluminum hydride together.
COPYRIGHT: (C)1979,JPO&Japio
JP14324877A 1977-12-01 1977-12-01 Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide Pending JPS5479269A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14324877A JPS5479269A (en) 1977-12-01 1977-12-01 Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14324877A JPS5479269A (en) 1977-12-01 1977-12-01 Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide

Publications (1)

Publication Number Publication Date
JPS5479269A true JPS5479269A (en) 1979-06-25

Family

ID=15334324

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14324877A Pending JPS5479269A (en) 1977-12-01 1977-12-01 Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide

Country Status (1)

Country Link
JP (1) JPS5479269A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11395820B2 (en) 2016-03-16 2022-07-26 H. Lee Moffitt Cancer Center And Research Institute, Inc. Small molecules against cereblon to enhance effector t cell function
US11730726B2 (en) 2018-07-11 2023-08-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. Dimeric immuno-modulatory compounds against cereblon-based mechanisms

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11395820B2 (en) 2016-03-16 2022-07-26 H. Lee Moffitt Cancer Center And Research Institute, Inc. Small molecules against cereblon to enhance effector t cell function
US11730726B2 (en) 2018-07-11 2023-08-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. Dimeric immuno-modulatory compounds against cereblon-based mechanisms

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