JPS5479269A - Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide - Google Patents
Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilideInfo
- Publication number
- JPS5479269A JPS5479269A JP14324877A JP14324877A JPS5479269A JP S5479269 A JPS5479269 A JP S5479269A JP 14324877 A JP14324877 A JP 14324877A JP 14324877 A JP14324877 A JP 14324877A JP S5479269 A JPS5479269 A JP S5479269A
- Authority
- JP
- Japan
- Prior art keywords
- optically active
- pyrrolidinecarboxy
- anilide
- oxo
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrrole Compounds (AREA)
Abstract
PURPOSE: To obtain the title compound of optical purity useful as an intermediate for d-2-(anilinomethyl)pyrrolidine, etc. which becomes a highly selective asymmetric reducing reagent, by reacting optically active glutamic acid with a specific amount or more of aniline.
CONSTITUTION: One part by wt. of optically active d-orl-glutamic acid is reacted with 5 parts by wt. or more, preferably 5.5 parts by wt. or more, more preferably 7.5 parts by wt. of aniline to form optically pure d-orl -5-oxo-2-pyrrolidinecarboxy anilide. USE;When used together with lithium aluminum hydride, the compound becomes a highly selective asymmetric reducing reagent. For example, l-phenethyl alcohol of high optical purity can be obtained by reducing acetophenone with d-2-(anilino methyl) pyrrolidine and lithium aluminum hydride together.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14324877A JPS5479269A (en) | 1977-12-01 | 1977-12-01 | Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14324877A JPS5479269A (en) | 1977-12-01 | 1977-12-01 | Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5479269A true JPS5479269A (en) | 1979-06-25 |
Family
ID=15334324
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14324877A Pending JPS5479269A (en) | 1977-12-01 | 1977-12-01 | Preparation of optically active 5-oxo-2-pyrrolidinecarboxy anilide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5479269A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11395820B2 (en) | 2016-03-16 | 2022-07-26 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Small molecules against cereblon to enhance effector t cell function |
US11730726B2 (en) | 2018-07-11 | 2023-08-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
-
1977
- 1977-12-01 JP JP14324877A patent/JPS5479269A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11395820B2 (en) | 2016-03-16 | 2022-07-26 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Small molecules against cereblon to enhance effector t cell function |
US11730726B2 (en) | 2018-07-11 | 2023-08-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Dimeric immuno-modulatory compounds against cereblon-based mechanisms |
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