ID28174A - Turunan 5-imino-13-deoksi antrasiklin, penggunaannya, dan proses pembuatannya - Google Patents

Turunan 5-imino-13-deoksi antrasiklin, penggunaannya, dan proses pembuatannya

Info

Publication number
ID28174A
ID28174A IDW20001994A ID20001994A ID28174A ID 28174 A ID28174 A ID 28174A ID W20001994 A IDW20001994 A ID W20001994A ID 20001994 A ID20001994 A ID 20001994A ID 28174 A ID28174 A ID 28174A
Authority
ID
Indonesia
Prior art keywords
imino
turunan
deoksi
antrasiklin
anthracycline derivatives
Prior art date
Application number
IDW20001994A
Other languages
English (en)
Inventor
Zini Zhang
Richard Olson
Original Assignee
Gem Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gem Pharmaceuticals Inc filed Critical Gem Pharmaceuticals Inc
Publication of ID28174A publication Critical patent/ID28174A/id

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IDW20001994A 1998-03-03 1999-03-03 Turunan 5-imino-13-deoksi antrasiklin, penggunaannya, dan proses pembuatannya ID28174A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/033,659 US5942605A (en) 1998-03-03 1998-03-03 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them

Publications (1)

Publication Number Publication Date
ID28174A true ID28174A (id) 2001-05-10

Family

ID=21871693

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW20001994A ID28174A (id) 1998-03-03 1999-03-03 Turunan 5-imino-13-deoksi antrasiklin, penggunaannya, dan proses pembuatannya

Country Status (23)

Country Link
US (1) US5942605A (id)
EP (1) EP1064294B1 (id)
JP (1) JP4615712B2 (id)
KR (1) KR100456088B1 (id)
CN (1) CN1154652C (id)
AT (1) ATE267206T1 (id)
AU (1) AU767348B2 (id)
BR (1) BR9908387A (id)
CA (1) CA2322424C (id)
CY (1) CY1106306T1 (id)
CZ (1) CZ301493B6 (id)
DE (1) DE69917440T2 (id)
DK (1) DK1064294T3 (id)
ES (1) ES2222692T3 (id)
HK (1) HK1036070A1 (id)
HU (1) HU228590B1 (id)
ID (1) ID28174A (id)
IL (2) IL138117A0 (id)
NZ (1) NZ507300A (id)
PT (1) PT1064294E (id)
RU (1) RU2239640C2 (id)
SI (1) SI1064294T1 (id)
WO (1) WO1999045015A1 (id)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012211397B2 (en) * 2004-11-08 2015-09-17 Gem Pharmaceuticals, Llc Compositions and Processes for Preparing 13-Deoxy-Anthracyclines
US7244829B2 (en) * 2004-11-08 2007-07-17 Gem Pharmaceuticals, Llc Compositions and processes for preparing 13-deoxy-anthracyclines
US7776832B2 (en) * 2006-04-21 2010-08-17 Gem Pharmaceuticals, Llc Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
US10450340B2 (en) * 2017-02-16 2019-10-22 Monopar Therapeutics Inc. 3′-deamino-3′-(2″-pyrroline-1″-yl)-5-imino-13-deoxyanthracyclines and methods of preparation

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1511559A (en) * 1975-09-26 1978-05-24 Farmaceutici Italia Anthracycline glycosides
US4088569A (en) * 1976-02-24 1978-05-09 Uop Inc. Mercaptan oxidation in a liquid hydrocarbon with a metal phthalocyanine catalyst
US4134903A (en) * 1976-08-07 1979-01-16 Societa Farmaceutici Italia S.P.A. Anthracycline ethers and their preparation
US4109076A (en) * 1977-09-08 1978-08-22 Sri International 5-iminodaunomycin
US4309503A (en) * 1978-02-09 1982-01-05 Farmitalia Carlo Erba S.P.A. Preparation of 11-deoxy anthracycline antibiotics
NL7900869A (nl) * 1978-02-09 1979-08-13 Erba Farmitalia Anthracyclinenantibiotica.
US4411834A (en) * 1978-02-09 1983-10-25 Farmitalia Carlo Erba, S.P.A. Preparation of II-deoxy anthracycline antibiotics
US4345070A (en) * 1980-09-29 1982-08-17 Farmitalia Carlo Erba S.P.A. Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin
US4353894A (en) * 1980-10-27 1982-10-12 Sri International 5-Iminodoxorubicin
GB8317037D0 (en) * 1983-06-23 1983-07-27 Erba Farmitalia 6-deoxyanthracyclines
US5138042A (en) * 1981-05-28 1992-08-11 Farmitalia Carlo Erba S.P.A. 6-deoxyanthracyclines
IT1210476B (it) * 1981-05-28 1989-09-14 Erba Farmitalia Antracicline.
ZA834867B (en) * 1982-07-20 1984-03-28 Stanford Res Inst Int Derivatives of morpholinyl daunorubicin and morpholinyl doxorubicin and analogues thereof
US4515720A (en) * 1983-03-11 1985-05-07 Oregon Graduate Center For Study & Research Method of synthesizing a late-stage intermediate to 11-deoxydaunorubicin and 11-deoxyadriamycin, and two precursors to the object intermediate
US4585859A (en) * 1983-05-24 1986-04-29 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
JPS6133194A (ja) * 1984-07-25 1986-02-17 Sanraku Inc 新規アントラサイクリン抗生物質
US4591637A (en) * 1985-01-17 1986-05-27 Sri International Open chain-morpholino adriamycins
GB8617742D0 (en) * 1986-07-21 1986-08-28 Erba Farmitalia 6-amino anthracyclines
GB2196626B (en) * 1986-10-15 1990-09-19 Erba Farmitalia Antitumor anthracycline glycosides, their preparation, intermediates thereof, and compositions and use therefor
NZ224252A (en) * 1987-04-21 1991-09-25 Erba Carlo Spa An anthracycline glycoside and its preparation
GB8803076D0 (en) * 1988-02-10 1988-03-09 Erba Carlo Spa 3'-deamino-4'-deoxy-4'-amino anthracyclines
US5412081A (en) * 1989-02-07 1995-05-02 Farmitalia Carlo Erba S.R.L. New 4'-epi-4'-amino anthracyclines
GB2238540B (en) * 1989-11-29 1993-09-29 Erba Carlo Spa 13-deoxy-4'-deoxy-4'-iodoanthracyclines
JPH05247080A (ja) * 1992-02-28 1993-09-24 Mercian Corp 新規アントラサイクリン系抗生物質
GB9325417D0 (en) * 1993-12-13 1994-02-16 Erba Carlo Spa 3'- aziridino-anthracycline derivatives
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives

Also Published As

Publication number Publication date
PT1064294E (pt) 2004-09-30
EP1064294B1 (en) 2004-05-19
IL138117A0 (en) 2001-10-31
HUP0102518A2 (hu) 2001-10-28
JP2002518293A (ja) 2002-06-25
HU228590B1 (en) 2013-04-29
JP4615712B2 (ja) 2011-01-19
ES2222692T3 (es) 2005-02-01
AU767348B2 (en) 2003-11-06
CZ20003178A3 (cs) 2001-02-14
HK1036070A1 (en) 2001-12-21
CA2322424A1 (en) 1999-09-10
SI1064294T1 (en) 2004-12-31
EP1064294A1 (en) 2001-01-03
CN1299366A (zh) 2001-06-13
CN1154652C (zh) 2004-06-23
AU2982099A (en) 1999-09-20
BR9908387A (pt) 2002-12-31
KR100456088B1 (ko) 2004-11-08
DE69917440D1 (de) 2004-06-24
WO1999045015A1 (en) 1999-09-10
CZ301493B6 (cs) 2010-03-24
US5942605A (en) 1999-08-24
HUP0102518A3 (en) 2002-12-28
DE69917440T2 (de) 2005-06-09
IL138117A (en) 2006-08-20
NZ507300A (en) 2005-02-25
KR20010034550A (ko) 2001-04-25
CY1106306T1 (el) 2011-10-12
RU2239640C2 (ru) 2004-11-10
CA2322424C (en) 2010-05-25
DK1064294T3 (da) 2004-09-27
ATE267206T1 (de) 2004-06-15

Similar Documents

Publication Publication Date Title
ID28146A (id) Benzoilsikloheksanadion, proses pembuatan dan penggunaannya sebagai herbisida dan zat pengatur tumbuh
ID28971A (id) Turunan 2-ureido-tiazol, proses pembuatannya, dan penggunaannya sebagai zat anti tumor
DK0915898T3 (da) Krystalform I af clarithromycin
ATE360706T1 (de) Peptidakzeptor ligationsverfahren
TR200100922T2 (tr) Aktif maddelerin akciğerler yolu ile tatbik edilmesi.
TR199600792A2 (tr) Dihaloazolopirimidinlerin hazirlanmasina yönelik proses.
ATE256138T1 (de) 9-oximsilyl erythromycin a derivate
MXPA02008801A (es) Derivados de indol, proceso para la preparacion de los mismos y su uso.
AU6350699A (en) Chemical compounds
AU2001247968A1 (en) Use of asiatic acid or asiaticoside for treatment of cancer
AU4224599A (en) Anti-prostate cancer vaccines, and methods of making, using and evaluating the same
ES2160410T3 (es) Preparados de complejos de protrombina inmunotolerantes.
DE59807248D1 (de) Implantatkörper
DE60113445D1 (de) Substanzen mit verzweigten linkermolekülen
ID24173A (id) 1,2,3,4,5,6 heksahidro-2-6-metano-3-benzazosin-10-ol, proses pembuatan dan penggunannya untuk obat-obatan
ID28174A (id) Turunan 5-imino-13-deoksi antrasiklin, penggunaannya, dan proses pembuatannya
ATE215941T1 (de) Isoflavonderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ID21968A (id) Turunan-turunan 11-asetil-12, 13-dioksabisiklo (8.2.1)-tridesenon, proses pembuatannya dan senyawa yang digunakan sebagai obat
ES2195378T3 (es) Procedimiento para la sintesis de taxanos.
PT1408035E (pt) Metodo de preparacao de derivativos de 1.5-diaril-3-trifluorometilo-delta2-pirazolinas que sejam racemicos e enanciomericamente puros
IL135516A0 (en) Process for n-desmethylating erythromycins and derivatives thereof
ID28958A (id) Proses penyiapan 4,6-disubstitusi 2-isosianatop irimidin dan penggunaannya sebagai penengah-penengah untuk sintesa-sintesa senyawa aktif
FI973631A (fi) 1,3-diolipohjaiset eetterit, menetelmä 1,3-diolipohjaisten eetterien valmistamiseksi sekä eetterien käyttö
TR199900070A3 (tr) Naftiridonlarin ve ara baglarin hazirlanmasina yönelik islem.
UA33267A (uk) Спосіб діагностики гострого отруєння алкоголем