DK1399138T3 - Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat - Google Patents

Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat

Info

Publication number
DK1399138T3
DK1399138T3 DK02743039T DK02743039T DK1399138T3 DK 1399138 T3 DK1399138 T3 DK 1399138T3 DK 02743039 T DK02743039 T DK 02743039T DK 02743039 T DK02743039 T DK 02743039T DK 1399138 T3 DK1399138 T3 DK 1399138T3
Authority
DK
Denmark
Prior art keywords
methylbutyrate
hydroxy
sodium
solid formulations
preparation
Prior art date
Application number
DK02743039T
Other languages
English (en)
Inventor
Brigitta Heyl-Frank
Heike Irle
Daniel Pianzola
Barry Jackson
Uwe Zacher
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of DK1399138T3 publication Critical patent/DK1399138T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK02743039T 2001-05-18 2002-05-17 Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat DK1399138T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01112236 2001-05-18

Publications (1)

Publication Number Publication Date
DK1399138T3 true DK1399138T3 (da) 2006-04-24

Family

ID=8177477

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02743039T DK1399138T3 (da) 2001-05-18 2002-05-17 Fremgangsmåde til fremstilling af faste formuleringer af natrium-3-hydroxy-3-methylbutyrat

Country Status (17)

Country Link
US (1) US7026507B2 (da)
EP (1) EP1399138B1 (da)
JP (1) JP4166580B2 (da)
CN (1) CN100542525C (da)
AT (1) ATE317259T1 (da)
AU (1) AU2002338953B2 (da)
BR (1) BR0209820A (da)
CA (1) CA2447417C (da)
CZ (1) CZ302823B6 (da)
DE (1) DE50205794D1 (da)
DK (1) DK1399138T3 (da)
ES (1) ES2257559T3 (da)
HK (1) HK1068813A1 (da)
HU (1) HUP0400080A3 (da)
MX (1) MXPA03010610A (da)
PL (1) PL367221A1 (da)
WO (1) WO2002094255A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402118D0 (en) 2004-01-30 2004-03-03 Merck Sharp & Dohme Polymorphic forms of a GABAA agonist
EP2292222A1 (en) 2005-01-28 2011-03-09 H. Lundbeck A/S Polymorphic Forms of a GABAA Agonist
AU2009242451C1 (en) 2008-05-02 2017-05-18 Gilead Sciences, Inc. The use of solid carrier particles to improve the processability of a pharmaceutical agent
EP2295593A1 (en) 2009-09-15 2011-03-16 Philippe Marliere Method for the enymatic production of 3-hydroxy-3-methylbutyric acid from acetone and acetyl-CoA
WO2012140276A2 (en) * 2011-11-17 2012-10-18 Lonza Ltd Process for the preparation of 3-hydroxy-3-methylbutyric acid or its calcium salts
ES2899261T3 (es) * 2015-11-19 2022-03-10 Kyowa Hakko Bio Co Ltd Cristales de una sal de un catión monovalente de ácido 3-hidroxiisovalérico y método para producir dichos cristales
RU2018145506A (ru) 2016-06-24 2020-07-27 Оцука Фармасьютикал Фэктори, Инк. Кристаллическая аминокислотная соль 3-гидроксиизовалериановой кислоты и способ ее получения
WO2019016883A1 (ja) * 2017-07-19 2019-01-24 小林香料株式会社 ３－ヒドロキシ－３－メチルブタン酸又はその塩の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994006417A1 (en) 1992-09-16 1994-03-31 Iowa State University Research Foundation, Inc. Method of reducing blood levels of total cholesterol and low-density lipoprotein cholesterol
US5348979A (en) 1992-12-23 1994-09-20 Iowa State University Research Foundation Inc. Method of promoting nitrogen retention in humans
US6090978A (en) * 1996-07-19 2000-07-18 Met-Rx Usa, Inc. Process for manufacturing 3-hydroxy-3-methylbutanoic acid
WO1998034897A1 (de) 1997-02-10 1998-08-13 Lonza Ag Verfahren zur herstellung von 3-hydroxy-3-methylbuttersäure oder deren salze
EP1109798B1 (en) * 1998-09-03 2005-10-12 Firmenich Sa Geranic acid derivatives

Also Published As

Publication number Publication date
US20040143136A1 (en) 2004-07-22
AU2002338953B2 (en) 2006-06-29
CA2447417C (en) 2011-10-04
US7026507B2 (en) 2006-04-11
AU2002338953C1 (en) 2002-12-03
ES2257559T3 (es) 2006-08-01
JP2004536065A (ja) 2004-12-02
EP1399138A1 (de) 2004-03-24
CZ20032965A3 (cs) 2004-02-18
DE50205794D1 (de) 2006-04-20
HUP0400080A3 (en) 2004-10-28
MXPA03010610A (es) 2004-04-02
HK1068813A1 (en) 2005-05-06
CN100542525C (zh) 2009-09-23
JP4166580B2 (ja) 2008-10-15
HUP0400080A2 (hu) 2004-05-28
EP1399138B1 (de) 2006-02-08
WO2002094255A1 (de) 2002-11-28
PL367221A1 (en) 2005-02-21
ATE317259T1 (de) 2006-02-15
CN1523983A (zh) 2004-08-25
CZ302823B6 (cs) 2011-11-30
BR0209820A (pt) 2004-06-01
CA2447417A1 (en) 2002-11-28

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