NO995924L - Fremgangsmåte ved fremstillingen av 1,4,7,10- tetraazacyklododekan-1,4,7-trieddiksyre og derivater derav - Google Patents

Fremgangsmåte ved fremstillingen av 1,4,7,10- tetraazacyklododekan-1,4,7-trieddiksyre og derivater derav

Info

Publication number
NO995924L
NO995924L NO995924A NO995924A NO995924L NO 995924 L NO995924 L NO 995924L NO 995924 A NO995924 A NO 995924A NO 995924 A NO995924 A NO 995924A NO 995924 L NO995924 L NO 995924L
Authority
NO
Norway
Prior art keywords
preparation
triacetic acid
tetraazacyclododecan
derivatives
acid
Prior art date
Application number
NO995924A
Other languages
English (en)
Other versions
NO312548B1 (no
NO995924D0 (no
Inventor
Giorgio Ripa
Alessandro Scala
Marcella Murru
Emanuela Panetta
Carlo Felice Viscardi
Marina Ausonio
Original Assignee
Bracco Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Spa filed Critical Bracco Spa
Publication of NO995924D0 publication Critical patent/NO995924D0/no
Publication of NO995924L publication Critical patent/NO995924L/no
Publication of NO312548B1 publication Critical patent/NO312548B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
NO19995924A 1997-06-11 1999-12-03 Fremgangsmåte ved fremstillingen av 1,4,7,10- tetraazacyklododekan-1,4,7-trieddiksyre og derivater derav NO312548B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI001373A IT1292130B1 (it) 1997-06-11 1997-06-11 Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
PCT/EP1998/003408 WO1998056776A1 (en) 1997-06-11 1998-06-08 A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the derivatives thereof

Publications (3)

Publication Number Publication Date
NO995924D0 NO995924D0 (no) 1999-12-03
NO995924L true NO995924L (no) 2000-01-26
NO312548B1 NO312548B1 (no) 2002-05-27

Family

ID=11377338

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19995924A NO312548B1 (no) 1997-06-11 1999-12-03 Fremgangsmåte ved fremstillingen av 1,4,7,10- tetraazacyklododekan-1,4,7-trieddiksyre og derivater derav

Country Status (14)

Country Link
US (2) US5962679A (no)
EP (1) EP0989974B1 (no)
JP (2) JP4445042B2 (no)
CN (2) CN1215063C (no)
AT (1) ATE224379T1 (no)
AU (1) AU738506B2 (no)
DE (1) DE69808086T2 (no)
ES (1) ES2184302T3 (no)
IL (1) IL131255A (no)
IN (1) IN186470B (no)
IT (1) IT1292130B1 (no)
NO (1) NO312548B1 (no)
WO (1) WO1998056776A1 (no)
ZA (1) ZA985023B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
US6166201A (en) * 1999-06-25 2000-12-26 Dibra S.P.A. Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof
US6838557B1 (en) * 2002-10-01 2005-01-04 Board Of Regents The University Of Texas System Process for making a chelating agent for labeling biomolecules using preformed active esters
US6852854B1 (en) 2002-10-01 2005-02-08 Psiloquest Inc. Preformed carboxylated active ester for labeling biomolecules
US20050033106A1 (en) * 2003-07-08 2005-02-10 Wing Tak Wong Synthesis of tris N-alkylated 1,4,7,10-tetraazacyclododecanes
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
CN103232403B (zh) * 2013-05-09 2016-04-27 浙江凯普化工有限公司 一种氮杂环的制备方法
CA2913835C (en) * 2013-05-30 2021-04-20 Bracco Imaging S.P.A. Fluorescent solid lipid nanoparticles composition and preparation thereof
CN108084105B (zh) * 2016-11-23 2020-07-24 四川科伦药物研究院有限公司 钆特醇中间体及其合成方法和利用该钆特醇中间体制备钆特醇的方法
KR101971435B1 (ko) * 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
EP3870569A4 (en) * 2018-10-24 2022-08-24 Biophore India Pharmaceuticals Pvt. Ltd. NEW PROCESS FOR THE PREPARATION OF MACROCYCLIC CHELATING TRIACETIC ACID 2,2',2''-(10-(2-HYDROXYPROPYL)-1,4,7,10-TETRA AZACYCLODODECANE-1,4,7-TRIYL) AND ITS COMPLEXES WITH PARAMAGNETIC METALLIC IONS
US20200397924A1 (en) * 2019-01-28 2020-12-24 Hubei Tianshu Pharmaceutical Co., Ltd Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210114742A (ko) * 2020-03-11 2021-09-24 주식회사 엔지켐생명과학 칼테리돌의 제조방법
CN113549025B (zh) * 2021-07-14 2023-07-25 江苏美迪克化学品有限公司 一种1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸及其钠盐的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2644453A1 (fr) * 1989-03-20 1990-09-21 Centre Nat Rech Scient Procede de preparation de tetramines cycliques monofonctionnalisees
IT1243801B (it) * 1990-08-29 1994-06-28 Bracco Ind Chimica Spa Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
EP0702677A1 (en) * 1994-04-08 1996-03-27 BRACCO International B.V. Aromatic amide compounds and metal chelates thereof
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati

Also Published As

Publication number Publication date
IL131255A (en) 2004-01-04
EP0989974A1 (en) 2000-04-05
NO312548B1 (no) 2002-05-27
CN1251094A (zh) 2000-04-19
IT1292130B1 (it) 1999-01-25
JP4445042B2 (ja) 2010-04-07
WO1998056776A1 (en) 1998-12-17
JP5204724B2 (ja) 2013-06-05
US6054581A (en) 2000-04-25
CN1117088C (zh) 2003-08-06
ES2184302T3 (es) 2003-04-01
DE69808086T2 (de) 2003-06-05
CN1473819A (zh) 2004-02-11
EP0989974B1 (en) 2002-09-18
JP2009242405A (ja) 2009-10-22
ITMI971373A0 (no) 1997-06-11
IN186470B (no) 2001-09-08
IL131255A0 (en) 2001-01-28
ITMI971373A1 (it) 1998-12-11
ZA985023B (en) 1999-01-20
US5962679A (en) 1999-10-05
AU8436998A (en) 1998-12-30
NO995924D0 (no) 1999-12-03
DE69808086D1 (de) 2002-10-24
JP2002503238A (ja) 2002-01-29
ATE224379T1 (de) 2002-10-15
AU738506B2 (en) 2001-09-20
CN1215063C (zh) 2005-08-17

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