DE69808086T2 - Ein verfahren zur herstellung von 1,4,7,10-tetraazacyclododecan-1,4,7-triessigsäure und deren derivaten - Google Patents

Ein verfahren zur herstellung von 1,4,7,10-tetraazacyclododecan-1,4,7-triessigsäure und deren derivaten

Info

Publication number
DE69808086T2
DE69808086T2 DE69808086T DE69808086T DE69808086T2 DE 69808086 T2 DE69808086 T2 DE 69808086T2 DE 69808086 T DE69808086 T DE 69808086T DE 69808086 T DE69808086 T DE 69808086T DE 69808086 T2 DE69808086 T2 DE 69808086T2
Authority
DE
Germany
Prior art keywords
acid
tricessic
tetraazacyclododecan
derivatives
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69808086T
Other languages
English (en)
Other versions
DE69808086D1 (de
Inventor
Giorgio Ripa
Alessandro Scala
Marcella Murru
Emanuela Panetta
Felice Viscardi
Marina Ausonio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco International BV
Original Assignee
Bracco International BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco International BV filed Critical Bracco International BV
Publication of DE69808086D1 publication Critical patent/DE69808086D1/de
Application granted granted Critical
Publication of DE69808086T2 publication Critical patent/DE69808086T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
DE69808086T 1997-06-11 1998-06-08 Ein verfahren zur herstellung von 1,4,7,10-tetraazacyclododecan-1,4,7-triessigsäure und deren derivaten Expired - Lifetime DE69808086T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI001373A IT1292130B1 (it) 1997-06-11 1997-06-11 Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
PCT/EP1998/003408 WO1998056776A1 (en) 1997-06-11 1998-06-08 A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the derivatives thereof

Publications (2)

Publication Number Publication Date
DE69808086D1 DE69808086D1 (de) 2002-10-24
DE69808086T2 true DE69808086T2 (de) 2003-06-05

Family

ID=11377338

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69808086T Expired - Lifetime DE69808086T2 (de) 1997-06-11 1998-06-08 Ein verfahren zur herstellung von 1,4,7,10-tetraazacyclododecan-1,4,7-triessigsäure und deren derivaten

Country Status (14)

Country Link
US (2) US5962679A (de)
EP (1) EP0989974B1 (de)
JP (2) JP4445042B2 (de)
CN (2) CN1215063C (de)
AT (1) ATE224379T1 (de)
AU (1) AU738506B2 (de)
DE (1) DE69808086T2 (de)
ES (1) ES2184302T3 (de)
IL (1) IL131255A (de)
IN (1) IN186470B (de)
IT (1) IT1292130B1 (de)
NO (1) NO312548B1 (de)
WO (1) WO1998056776A1 (de)
ZA (1) ZA985023B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
US6166201A (en) * 1999-06-25 2000-12-26 Dibra S.P.A. Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof
US6852854B1 (en) 2002-10-01 2005-02-08 Psiloquest Inc. Preformed carboxylated active ester for labeling biomolecules
US6838557B1 (en) * 2002-10-01 2005-01-04 Board Of Regents The University Of Texas System Process for making a chelating agent for labeling biomolecules using preformed active esters
US20050033106A1 (en) * 2003-07-08 2005-02-10 Wing Tak Wong Synthesis of tris N-alkylated 1,4,7,10-tetraazacyclododecanes
DE102009053171B4 (de) 2009-11-04 2011-07-21 Bayer Schering Pharma Aktiengesellschaft, 13353 Verfahren zur Herstellung des Calcium-Komplexes von Dihydroxy-hydroxy-methylpropyl-tetraazacyclododecan-triessigsäure (Calcobutrol)
CN103232403B (zh) * 2013-05-09 2016-04-27 浙江凯普化工有限公司 一种氮杂环的制备方法
CN105377309A (zh) * 2013-05-30 2016-03-02 伯拉考成像股份公司 荧光固体脂质纳米颗粒组合物及其制备
CN108084105B (zh) * 2016-11-23 2020-07-24 四川科伦药物研究院有限公司 钆特醇中间体及其合成方法和利用该钆特醇中间体制备钆特醇的方法
KR101971435B1 (ko) 2017-08-29 2019-04-24 주식회사 엔지켐생명과학 가도부트롤 중간체 및 이를 이용한 가도부트롤의 제조 방법
EP3870569A4 (de) * 2018-10-24 2022-08-24 Biophore India Pharmaceuticals Pvt. Ltd. Neues verfahren zur herstellung von makrocyclischer chelatbildender 2,2',2''-(10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecan-1,4,7-triyl)-triessigsäure und ihren komplexen mit paramagnetischen metallionen
US20200397924A1 (en) * 2019-01-28 2020-12-24 Hubei Tianshu Pharmaceutical Co., Ltd Preparation method of intermediate of gadolinium-based ionic contrast agent and use thereof
CN111039885B (zh) * 2019-12-06 2021-03-05 广州康瑞泰药业有限公司 一种制备高纯度考布曲钙的方法
KR20210114742A (ko) * 2020-03-11 2021-09-24 주식회사 엔지켐생명과학 칼테리돌의 제조방법
CN113549025B (zh) * 2021-07-14 2023-07-25 江苏美迪克化学品有限公司 一种1,4,7,10-四氮杂环十二烷-1,4,7-三乙酸及其钠盐的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2644453A1 (fr) * 1989-03-20 1990-09-21 Centre Nat Rech Scient Procede de preparation de tetramines cycliques monofonctionnalisees
IT1243801B (it) * 1990-08-29 1994-06-28 Bracco Ind Chimica Spa Intermedi per agenti chelanti con simmetria prefissata, e procedimentoper la loro preparazione
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
US5410043A (en) * 1991-12-06 1995-04-25 Schering Aktiengesellschaft Process for the production of mono-N-substituted tetraaza macrocycles
DE4218744C2 (de) * 1992-06-04 1997-11-06 Schering Ag Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
WO1995027705A1 (en) * 1994-04-08 1995-10-19 Bracco International B.V. Aromatic amide compounds and metal chelates thereof
IT1292130B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione dell'acido 1,4,7,10-tetraazaciclododecan -1,4,7-triacetico e suoi derivati
IT1292128B1 (it) * 1997-06-11 1999-01-25 Bracco Spa Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici

Also Published As

Publication number Publication date
ATE224379T1 (de) 2002-10-15
JP4445042B2 (ja) 2010-04-07
IL131255A0 (en) 2001-01-28
ES2184302T3 (es) 2003-04-01
ITMI971373A0 (de) 1997-06-11
JP2002503238A (ja) 2002-01-29
NO995924L (no) 2000-01-26
WO1998056776A1 (en) 1998-12-17
AU8436998A (en) 1998-12-30
ZA985023B (en) 1999-01-20
US5962679A (en) 1999-10-05
AU738506B2 (en) 2001-09-20
NO995924D0 (no) 1999-12-03
CN1117088C (zh) 2003-08-06
EP0989974A1 (de) 2000-04-05
US6054581A (en) 2000-04-25
IN186470B (de) 2001-09-08
JP5204724B2 (ja) 2013-06-05
DE69808086D1 (de) 2002-10-24
CN1215063C (zh) 2005-08-17
IT1292130B1 (it) 1999-01-25
EP0989974B1 (de) 2002-09-18
CN1251094A (zh) 2000-04-19
JP2009242405A (ja) 2009-10-22
ITMI971373A1 (it) 1998-12-11
IL131255A (en) 2004-01-04
NO312548B1 (no) 2002-05-27
CN1473819A (zh) 2004-02-11

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