ATE199714T1 - Verfahren zur herstellung von 5-hydroxymethyl- thiazole - Google Patents
Verfahren zur herstellung von 5-hydroxymethyl- thiazoleInfo
- Publication number
- ATE199714T1 ATE199714T1 AT95940008T AT95940008T ATE199714T1 AT E199714 T1 ATE199714 T1 AT E199714T1 AT 95940008 T AT95940008 T AT 95940008T AT 95940008 T AT95940008 T AT 95940008T AT E199714 T1 ATE199714 T1 AT E199714T1
- Authority
- AT
- Austria
- Prior art keywords
- thiazole
- hydroxymethyl
- producing
- hydroxymethylthiazole
- hydrolyzing
- Prior art date
Links
- WKBQQWDVVHGWDB-UHFFFAOYSA-N 1,3-thiazol-5-ylmethanol Chemical compound OCC1=CN=CS1 WKBQQWDVVHGWDB-UHFFFAOYSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001734 carboxylic acid salts Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006298 dechlorination reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34369094A | 1994-11-22 | 1994-11-22 | |
| PCT/US1995/014930 WO1996016050A1 (en) | 1994-11-22 | 1995-11-15 | Process for preparation of 5-hydroxymethylthiazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE199714T1 true ATE199714T1 (de) | 2001-03-15 |
Family
ID=23347195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95940008T ATE199714T1 (de) | 1994-11-22 | 1995-11-15 | Verfahren zur herstellung von 5-hydroxymethyl- thiazole |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5712400A (de) |
| EP (1) | EP0793659B1 (de) |
| JP (1) | JPH10509177A (de) |
| AT (1) | ATE199714T1 (de) |
| DE (1) | DE69520368T2 (de) |
| DK (1) | DK0793659T3 (de) |
| ES (1) | ES2156955T3 (de) |
| GR (1) | GR3035865T3 (de) |
| MX (1) | MX9703766A (de) |
| PT (1) | PT793659E (de) |
| WO (1) | WO1996016050A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998032747A1 (en) * | 1997-01-22 | 1998-07-30 | Novartis Ag | Process for the preparation of thiazole derivatives |
| US5932736A (en) * | 1997-04-07 | 1999-08-03 | Reilly Industries, Inc. | Preparation of heterocycles using 1,3-dihalopropenes |
| WO1998045279A1 (en) * | 1997-04-07 | 1998-10-15 | Reilly Industries, Inc. | Preparation of thiazoles using 1,3-dihalopropenes |
| US5959118A (en) * | 1997-08-29 | 1999-09-28 | Abbott Laboratories | Process for the preparation of 5-hydroxymethylthiazoles |
| US5773625A (en) * | 1997-10-02 | 1998-06-30 | Abbott Laboratories | Process for the preparation of disubstituted carbonates |
| US6765019B1 (en) | 1999-05-06 | 2004-07-20 | University Of Kentucky Research Foundation | Permeable, water soluble, non-irritating prodrugs of chemotherapeutic agents with oxaalkanoic acids |
| CN101260100A (zh) * | 2008-04-21 | 2008-09-10 | 湖南有色凯铂生物药业有限公司 | 一种5-羟甲基噻唑的制备方法 |
| CN101863853B (zh) * | 2009-12-28 | 2012-12-19 | 安徽贝克联合制药有限公司 | 一锅煮法制备5-羟甲基噻唑工艺 |
| EP3700893B1 (de) | 2017-10-27 | 2021-11-17 | Syngenta Participations AG | Zusammensetzungen für die vektorsteuerung, verfahren und produkte diese verwendend |
| CN116375662B (zh) * | 2022-12-30 | 2024-07-23 | 新沂市砥研医药技术研究院有限公司 | 一种高效的5-羟甲基噻唑医药中间体的纯化工艺 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247464A (en) * | 1979-10-01 | 1981-01-27 | General Electric Company | Liquid extraction method for recovering aromatic bisimides |
| DE3631538A1 (de) * | 1986-09-17 | 1988-03-24 | Bayer Ag | Verfahren zur herstellung von 2-chlor-5-chlormethylthiazol |
| JPS63165334A (ja) * | 1986-12-27 | 1988-07-08 | Hodogaya Chem Co Ltd | ２，６−ジクロロベンジルアルコ−ルの製造法 |
| IE913840A1 (en) * | 1990-11-20 | 1992-05-20 | Abbott Lab | Retroviral protease inhibiting compounds |
| KR100187613B1 (ko) * | 1992-12-29 | 1999-06-01 | 스티븐 에프. 웨인스톡 | 레트로바이러스성 프로테이제 억제 화합물, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
-
1995
- 1995-11-15 EP EP95940008A patent/EP0793659B1/de not_active Expired - Lifetime
- 1995-11-15 ES ES95940008T patent/ES2156955T3/es not_active Expired - Lifetime
- 1995-11-15 AT AT95940008T patent/ATE199714T1/de not_active IP Right Cessation
- 1995-11-15 JP JP8516978A patent/JPH10509177A/ja not_active Ceased
- 1995-11-15 MX MX9703766A patent/MX9703766A/es unknown
- 1995-11-15 DE DE69520368T patent/DE69520368T2/de not_active Expired - Fee Related
- 1995-11-15 PT PT95940008T patent/PT793659E/pt unknown
- 1995-11-15 DK DK95940008T patent/DK0793659T3/da active
- 1995-11-15 WO PCT/US1995/014930 patent/WO1996016050A1/en not_active Ceased
-
1996
- 1996-05-22 US US08/651,439 patent/US5712400A/en not_active Expired - Fee Related
-
2001
- 2001-05-15 GR GR20010400716T patent/GR3035865T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MX9703766A (es) | 1997-08-30 |
| US5712400A (en) | 1998-01-27 |
| DE69520368T2 (de) | 2001-06-28 |
| ES2156955T3 (es) | 2001-08-01 |
| WO1996016050A1 (en) | 1996-05-30 |
| JPH10509177A (ja) | 1998-09-08 |
| EP0793659A1 (de) | 1997-09-10 |
| EP0793659B1 (de) | 2001-03-14 |
| GR3035865T3 (en) | 2001-08-31 |
| PT793659E (pt) | 2001-07-31 |
| DE69520368D1 (de) | 2001-04-19 |
| DK0793659T3 (da) | 2001-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |