CN111039885B - 一种制备高纯度考布曲钙的方法 - Google Patents
一种制备高纯度考布曲钙的方法 Download PDFInfo
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- CN111039885B CN111039885B CN201911243600.XA CN201911243600A CN111039885B CN 111039885 B CN111039885 B CN 111039885B CN 201911243600 A CN201911243600 A CN 201911243600A CN 111039885 B CN111039885 B CN 111039885B
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- Prior art keywords
- combretastatin
- calcium
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- purity
- formula
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Description
X-Ray | 40kV,40mA | 扫描速度 | 10deg/min |
仪器型号 | Ultima IV | 步长 | 0.0200deg |
样品台 | 标准 | 扫描轴 | Theta/2-Theta |
滤片 | Cu_K-beta | 扫描范围 | 3.0-60.0deg |
测角仪 | 标准 | 入射狭缝 | 1/2deg |
衍射单色器 | None | 限高狭缝 | 10.0mm |
探测器 | D/tex Ultra | 接收狭缝#1 | Open |
扫描模式 | CONTINUOUS | 接收狭缝#2 | Open |
Claims (4)
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CN201911243600.XA CN111039885B (zh) | 2019-12-06 | 2019-12-06 | 一种制备高纯度考布曲钙的方法 |
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CN201911243600.XA CN111039885B (zh) | 2019-12-06 | 2019-12-06 | 一种制备高纯度考布曲钙的方法 |
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CN111039885A CN111039885A (zh) | 2020-04-21 |
CN111039885B true CN111039885B (zh) | 2021-03-05 |
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Families Citing this family (1)
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CN114573522A (zh) * | 2020-11-30 | 2022-06-03 | 江苏恒瑞医药股份有限公司 | 一种考布曲钙的新晶型及其制备方法 |
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2019
- 2019-12-06 CN CN201911243600.XA patent/CN111039885B/zh active Active
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CN1259939A (zh) * | 1997-06-11 | 2000-07-12 | 伯拉考公司 | 大环螯合剂及其与顺磁性金属离子的螯合物的制备方法 |
CN1481371A (zh) * | 2000-12-15 | 2004-03-10 | ���ֹɷݹ�˾ | N-(1-羟甲基-2,3-二羟丙基)-1,4,7-三羧甲基-1,4,7,10-四氮杂环十二烷的锂络合物、其制备方法及应用 |
CN102164901A (zh) * | 2009-11-04 | 2011-08-24 | 拜耳先灵医药股份有限公司 | 用于制备考布曲钙的方法 |
CN102933562A (zh) * | 2010-06-04 | 2013-02-13 | 拜耳知识产权有限责任公司 | 通过dmf缩醛和n-甲基咪唑在一锅法中制备钆布醇 |
CN102399199A (zh) * | 2010-09-19 | 2012-04-04 | 广州康臣药物研究有限公司 | 一种磁共振成像造影剂的制备方法 |
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CN106187930A (zh) * | 2016-07-12 | 2016-12-07 | 嘉实(湖南)医药科技有限公司 | 高纯度考布曲钙的制备方法 |
CN109803958A (zh) * | 2016-09-27 | 2019-05-24 | 拜耳制药股份公司 | 生产考布曲钙的变型a的晶型的方法 |
CN109384737A (zh) * | 2017-08-04 | 2019-02-26 | 天津科伦药物研究有限公司 | 一种四氮杂环钇络合物及其制备方法和应用 |
WO2019143074A1 (ko) * | 2018-01-19 | 2019-07-25 | 주식회사 엔지켐생명과학 | 칼코부트롤의 제조방법 |
CN108299322A (zh) * | 2018-02-07 | 2018-07-20 | 广州康瑞泰药业有限公司 | 一种制备高纯度钆布醇的方法 |
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Title |
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