CN101863948A - 高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法 - Google Patents
高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法 Download PDFInfo
- Publication number
- CN101863948A CN101863948A CN200910103628A CN200910103628A CN101863948A CN 101863948 A CN101863948 A CN 101863948A CN 200910103628 A CN200910103628 A CN 200910103628A CN 200910103628 A CN200910103628 A CN 200910103628A CN 101863948 A CN101863948 A CN 101863948A
- Authority
- CN
- China
- Prior art keywords
- compound
- formula iii
- formula
- organic solvent
- purity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Description
Claims (17)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009101036283A CN101863948B (zh) | 2009-04-17 | 2009-04-17 | 高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法 |
PCT/CN2010/071820 WO2010118699A1 (zh) | 2009-04-17 | 2010-04-16 | 高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009101036283A CN101863948B (zh) | 2009-04-17 | 2009-04-17 | 高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101863948A true CN101863948A (zh) | 2010-10-20 |
CN101863948B CN101863948B (zh) | 2013-07-24 |
Family
ID=42955903
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009101036283A Active CN101863948B (zh) | 2009-04-17 | 2009-04-17 | 高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN101863948B (zh) |
WO (1) | WO2010118699A1 (zh) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103435675A (zh) * | 2013-09-25 | 2013-12-11 | 宜昌人福药业有限责任公司 | 一种甾类肌松药的精制方法 |
CN103588847A (zh) * | 2012-08-17 | 2014-02-19 | 重庆医药工业研究院有限责任公司 | 一种罗库溴铵中间体的制备方法 |
CN106810589A (zh) * | 2017-01-12 | 2017-06-09 | 成都新恒创药业有限公司 | 一种罗库溴铵异构体杂质或其盐及其制备方法 |
CN106950314A (zh) * | 2017-04-17 | 2017-07-14 | 南京健友生化制药股份有限公司 | 一种检测罗库溴铵或其注射液中烯丙基溴含量的方法 |
CN108570090A (zh) * | 2018-05-25 | 2018-09-25 | 江苏盈科生物制药有限公司 | 一种高纯度罗库溴铵的制备方法 |
CN111057122A (zh) * | 2019-12-25 | 2020-04-24 | 武汉华龙生物制药有限公司 | 一种罗库溴铵的制备方法 |
CN114088842A (zh) * | 2021-11-19 | 2022-02-25 | 江苏正济药业股份有限公司 | 一种罗库溴铵中间体及杂质的检测方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103119051B (zh) * | 2011-01-26 | 2015-09-23 | 浙江华海药业股份有限公司 | 罗库溴铵的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8708886D0 (en) * | 1987-04-14 | 1987-05-20 | Akzo Nv | 2beta-morpholino-androstane derivatives |
JP2008522983A (ja) * | 2005-09-13 | 2008-07-03 | シコール インコーポレイティド | ロクロニウムブロミドの合成方法 |
-
2009
- 2009-04-17 CN CN2009101036283A patent/CN101863948B/zh active Active
-
2010
- 2010-04-16 WO PCT/CN2010/071820 patent/WO2010118699A1/zh active Application Filing
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103588847A (zh) * | 2012-08-17 | 2014-02-19 | 重庆医药工业研究院有限责任公司 | 一种罗库溴铵中间体的制备方法 |
CN103435675A (zh) * | 2013-09-25 | 2013-12-11 | 宜昌人福药业有限责任公司 | 一种甾类肌松药的精制方法 |
CN103435675B (zh) * | 2013-09-25 | 2015-05-13 | 宜昌人福药业有限责任公司 | 一种甾类肌松药的精制方法 |
CN106810589A (zh) * | 2017-01-12 | 2017-06-09 | 成都新恒创药业有限公司 | 一种罗库溴铵异构体杂质或其盐及其制备方法 |
CN106950314A (zh) * | 2017-04-17 | 2017-07-14 | 南京健友生化制药股份有限公司 | 一种检测罗库溴铵或其注射液中烯丙基溴含量的方法 |
CN108570090A (zh) * | 2018-05-25 | 2018-09-25 | 江苏盈科生物制药有限公司 | 一种高纯度罗库溴铵的制备方法 |
CN108570090B (zh) * | 2018-05-25 | 2021-02-02 | 江苏盈科生物制药有限公司 | 一种高纯度罗库溴铵的制备方法 |
CN111057122A (zh) * | 2019-12-25 | 2020-04-24 | 武汉华龙生物制药有限公司 | 一种罗库溴铵的制备方法 |
CN111057122B (zh) * | 2019-12-25 | 2021-04-30 | 武汉华龙生物制药有限公司 | 一种罗库溴铵的制备方法 |
CN114088842A (zh) * | 2021-11-19 | 2022-02-25 | 江苏正济药业股份有限公司 | 一种罗库溴铵中间体及杂质的检测方法 |
Also Published As
Publication number | Publication date |
---|---|
CN101863948B (zh) | 2013-07-24 |
WO2010118699A1 (zh) | 2010-10-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101863948B (zh) | 高纯度(2β,3α,5α,16β,17β)-2-(4-吗啉基)-16-(1-吡咯烷基)-雄甾烷-3,17-二醇或其组合物及其制备方法 | |
CN1753905A (zh) | 获得17α-乙酰氧基-11β-(4-N,N-二甲氨基苯基)-19-去甲孕甾-4,9-二烯-3,20-二酮的方法 | |
CN102351778A (zh) | 一种盐酸阿比朵尔的制备方法 | |
CN109608468B (zh) | 一种枸橼酸托法替布杂质及其合成方法和用途 | |
CN103351322B (zh) | 一种奥拉西坦的合成方法 | |
EP2669293B1 (en) | Preparation method of rocuronium | |
WO2014102834A2 (en) | Process for lurasidone | |
CN110804022B (zh) | 一种右丙亚胺的制备方法 | |
CN114989061A (zh) | 一种布瓦西坦的制备方法 | |
CN107573291A (zh) | 一种钆塞酸二钠配体杂质的制备方法和用途 | |
CN101298448B (zh) | 2-苄氧基-3-乙基-4-甲基-5-氯-6-[(四氢-2h-吡喃-2-氧基)甲基]苯酚的合成方法 | |
CN111100042B (zh) | 一种2-甲氧基-5-磺酰胺基苯甲酸的制备方法 | |
CN109678919B (zh) | 一种琥珀酸甲泼尼龙杂质的制备方法 | |
CN109232254B (zh) | 一种化合物的合成方法及应用 | |
CN113185552A (zh) | 一种富马酸丙酚替诺福韦降解杂质的制备方法 | |
CN110615751A (zh) | 一种2-氧代硫代丙酰胺的制备方法 | |
CN109942442A (zh) | 一种盐酸达泊西汀有关物质i的制备方法 | |
CN112142595B (zh) | 一种2,4,5三氟苯甲酰乙酸乙酯的制备方法及纯化方法 | |
CN111320664A (zh) | 一种24-胆烯烯酸乙酯的制备方法 | |
CN105712920B (zh) | 一种维格列汀的制备方法 | |
CN115417803B (zh) | 乌帕替尼中间体(3r,4s)-1-苄氧羰基-4-乙基吡咯烷-3-羧酸的合成方法 | |
CN116903468B (zh) | 一种米洛巴林中间体的制备方法 | |
CN109369425B (zh) | 非诺贝特酸胆碱盐的制备方法 | |
KR100911720B1 (ko) | 결정형 염산 사포그릴레이트의 제조방법 | |
CN112094241A (zh) | 一种1,4-二氮杂螺[5,5]十一烷-3-酮的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20181226 Address after: 401221 No. 2 Yanjiahua South Third Branch Road, Changshou District, Chongqing Co-patentee after: Chongqing Pharmaceutical Research Institute Co., Ltd. Patentee after: Chongqing Medical Institute Pharmaceutical Co., Ltd. Address before: 400061 Tu Shan Road, South Bank district, Chongqing, No. 565 Patentee before: Chongqing Pharmaceutical Research Institute Co., Ltd. |
|
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20200421 Address after: 401221 No.3, Huanan 1st branch road, Changhua chemical industry park, Changshou District, Chongqing Co-patentee after: CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE Co.,Ltd. Patentee after: CHONGQING CARELIFE PHARMACEUTICAL Co.,Ltd. Address before: 401221 No. 2 Yanjiahua South Third Branch Road, Changshou District, Chongqing Co-patentee before: CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE Co.,Ltd. Patentee before: Chongqing Medical Institute Pharmaceutical Co., Ltd. |
|
TR01 | Transfer of patent right |