ES2181663T3 - Procedimiento para la preparacion de citalopram puro. - Google Patents

Procedimiento para la preparacion de citalopram puro.

Info

Publication number
ES2181663T3
ES2181663T3 ES01913727T ES01913727T ES2181663T3 ES 2181663 T3 ES2181663 T3 ES 2181663T3 ES 01913727 T ES01913727 T ES 01913727T ES 01913727 T ES01913727 T ES 01913727T ES 2181663 T3 ES2181663 T3 ES 2181663T3
Authority
ES
Spain
Prior art keywords
citalopram
preparation
cyanide
subjected
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01913727T
Other languages
English (en)
Inventor
Andrea Castellin
Giulio Volpe
Federico Sbrogio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Application granted granted Critical
Publication of ES2181663T3 publication Critical patent/ES2181663T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Un procedimiento para la preparación de citalopram de fórmula en el que un compuesto de fórmula II en donde Z es yodo, bromo, cloro o CF3-(CF2)n-S02-0-, siendo n 0, 1, 2, 3, 4, 5, 6, 7 u 8, se somete a una reacción de intercambio con cianuro, en el que el grupo Z se intercambia con cianuro mediante la reacción con una fuente de cianuro; el producto de citalopram bruto resultante se somete, opcionalmente, a una cierta purificación inicial, y la base de citalopram bruta se somete, subsiguientemente, a un proceso de destilación en película; el producto de citalopram resultante se purifica entonces, opcionalmente, de forma adicional y se elabora y aísla en forma de la base o una sal farmacéuticamente aceptable del mismo.
ES01913727T 2000-12-28 2001-03-07 Procedimiento para la preparacion de citalopram puro. Expired - Lifetime ES2181663T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001943 2000-12-28

Publications (1)

Publication Number Publication Date
ES2181663T3 true ES2181663T3 (es) 2003-03-01

Family

ID=8159933

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01913727T Expired - Lifetime ES2181663T3 (es) 2000-12-28 2001-03-07 Procedimiento para la preparacion de citalopram puro.
ES200101763A Expired - Lifetime ES2170733B1 (es) 2000-12-28 2001-07-27 Metodo para preparar citalopram purificado

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES200101763A Expired - Lifetime ES2170733B1 (es) 2000-12-28 2001-07-27 Metodo para preparar citalopram purificado

Country Status (41)

Country Link
US (2) US6855834B2 (es)
EP (1) EP1181272B1 (es)
JP (1) JP2003519121A (es)
KR (1) KR100430746B1 (es)
CN (1) CN1366526A (es)
AR (1) AR029898A1 (es)
AT (2) ATE222899T1 (es)
AU (3) AU3920201A (es)
BE (2) BE1013417A6 (es)
BG (1) BG106219A (es)
BR (1) BR0106271A (es)
CA (1) CA2359810C (es)
CH (1) CH691536A5 (es)
CZ (1) CZ293140B6 (es)
DE (1) DE60100016T2 (es)
DK (1) DK1181272T3 (es)
EA (1) EA003459B1 (es)
ES (2) ES2181663T3 (es)
FI (2) FI108640B (es)
FR (1) FR2818977B1 (es)
GB (2) GB2356199B (es)
GR (1) GR20010100131A (es)
HK (1) HK1049332A1 (es)
HR (1) HRP20020005A2 (es)
HU (2) HU0101028D0 (es)
IE (2) IES20010253A2 (es)
IL (1) IL147162A0 (es)
IS (1) IS5884A (es)
IT (1) ITMI20010604A1 (es)
MX (1) MXPA01013336A (es)
NL (1) NL1017534C1 (es)
NO (1) NO313047B1 (es)
NZ (1) NZ516299A (es)
PL (1) PL353369A1 (es)
PT (1) PT1181272E (es)
SE (1) SE0103044L (es)
SK (1) SK284418B6 (es)
TR (1) TR200200018T1 (es)
UA (1) UA71635C2 (es)
WO (1) WO2001047877A2 (es)
ZA (1) ZA200110133B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2319073A1 (es) * 2005-06-22 2009-05-01 H. Lundbeck A/S Base cristalina de escitalopram y comprimidos orodispersables que comprenden la base de escitalopram.

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
KR100604156B1 (ko) * 1999-04-14 2006-07-25 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조방법
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
HK1043129B (zh) 1999-10-25 2004-10-21 H‧隆德贝克有限公司 西酞普蘭的製備方法
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
CN1398263A (zh) 1999-12-28 2003-02-19 H·隆德贝克有限公司 制备西酞普兰的方法
HK1052512B (zh) 1999-12-30 2006-03-03 H. 隆德贝克有限公司 西酞普兰的制备方法
PL197821B1 (pl) 2000-01-14 2008-04-30 Lundbeck & Co As H Sposób wytwarzania 5-cyjanoftalidu
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
TR200202166T2 (tr) 2000-03-13 2002-12-23 H. Lndbeck A/S Sitalopramın preparasyon metodu
NZ521204A (en) * 2000-03-13 2004-03-26 H Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)- 1,3-dihydroisobenzofurans for preparing citalopram, an anti depressant
PT1265882E (pt) 2000-03-14 2004-06-30 Lundbeck & Co As H Metodo para preparacao de citalopram; composto e citalopram
HUP0300134A2 (en) * 2000-03-16 2003-05-28 Lundbeck & Co As H Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure citalopram
SK284418B6 (sk) 2000-12-28 2005-04-01 H. Lundbeck A/S Spôsob výroby citalopramu
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
AU2003222435A1 (en) 2002-01-07 2003-07-24 Sun Pharmaceutical Industries Limited Process for the preparation of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base

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DE2442426C2 (de) 1974-09-05 1983-04-07 Bayer Ag, 5090 Leverkusen Diisocyanatodiketene, Verfahren zu deren Herstellung und deren Verwendung
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US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
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DE69725717T2 (de) 1996-05-21 2004-07-29 Exxonmobil Chemical Patents Inc., Baytown Reinigung von glycidylestern durch dünnschichtverdampfung
US6136991A (en) * 1996-05-21 2000-10-24 Exxon Chemical Patents Inc. Glycidyl ester adducts having increased glass transition temperatures
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
SK283309B6 (sk) 1997-07-08 2003-05-02 H. Lundbeck A/S Spôsob výroby citalopramu a medziprodukty
DE19734673A1 (de) 1997-08-11 1999-02-18 Rwe Dea Ag Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
ES2149734T3 (es) 1997-11-11 2003-02-16 Lundbeck & Co As H Metodo para la preparacion de citalopram.
EP0965593B2 (en) 1998-06-19 2008-12-03 Shin-Etsu Chemical Co., Ltd. Distillation of (meth)acryloxybearing alkoxysilane
WO2000023431A1 (en) * 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
EP1140886B1 (en) 1998-12-23 2003-04-02 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
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ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
EP1228056B1 (en) 1999-10-25 2004-09-22 H. Lundbeck A/S Method for the preparation of citalopram
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IL147226A (en) 2000-12-22 2006-04-10 Lundbeck & Co As H Process for the preparation of pure citalopram
SK284418B6 (sk) 2000-12-28 2005-04-01 H. Lundbeck A/S Spôsob výroby citalopramu
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2319073A1 (es) * 2005-06-22 2009-05-01 H. Lundbeck A/S Base cristalina de escitalopram y comprimidos orodispersables que comprenden la base de escitalopram.
ES2319073B1 (es) * 2005-06-22 2010-02-26 H. Lundbeck A/S Base cristalina de escitalopram y comprimidos orodispersables que comprenden la base de escitalopram.

Also Published As

Publication number Publication date
IS5884A (is) 2002-06-28
PL353369A1 (en) 2003-11-17
GR20010100131A (el) 2002-10-09
ES2170733B1 (es) 2003-12-16
HU0101028D0 (en) 2001-05-28
AU750006B1 (en) 2002-07-11
WO2001047877A2 (en) 2001-07-05
GB2361697A (en) 2001-10-31
JP2003519121A (ja) 2003-06-17
HUP0102818A3 (en) 2003-07-28
SK284418B6 (sk) 2005-04-01
ITMI20010604A0 (it) 2001-03-22
CA2359810A1 (en) 2001-07-05
TR200200018T1 (tr) 2002-06-21
HK1049332A1 (zh) 2003-05-09
CA2359810C (en) 2002-11-05
GB2356199B (en) 2001-10-03
EP1181272B1 (en) 2002-08-28
EA003459B1 (ru) 2003-06-26
NZ516299A (en) 2002-12-20
NO20011272L (no) 2002-07-01
EA200200016A1 (ru) 2002-04-25
FI20011578A0 (fi) 2001-07-26
EP1181272A2 (en) 2002-02-27
CZ2001891A3 (cs) 2002-08-14
US20020087012A1 (en) 2002-07-04
DE60100016D1 (de) 2002-10-02
NO20011272D0 (no) 2001-03-13
UA71635C2 (uk) 2004-12-15
KR20020073379A (ko) 2002-09-26
CH691536A5 (de) 2001-08-15
NL1017534C1 (nl) 2001-04-26
US20030178295A1 (en) 2003-09-25
WO2001047877A3 (en) 2001-12-27
DK1181272T3 (da) 2002-12-30
BR0106271A (pt) 2002-05-21
HUP0102818A2 (hu) 2001-12-28
ZA200110133B (en) 2003-01-13
GB0117095D0 (en) 2001-09-05
AU2001100399B4 (en) 2002-03-21
NO313047B1 (no) 2002-08-05
IES20010253A2 (en) 2002-03-06
DE60100016T2 (de) 2003-04-17
HRP20020005A2 (en) 2003-04-30
ITMI20010604A1 (it) 2002-09-22
IES20010632A2 (en) 2002-03-06
SE0103044D0 (sv) 2001-09-14
BE1013316A6 (fr) 2001-11-06
AU3920201A (en) 2001-07-09
US6855834B2 (en) 2005-02-15
ES2170733A1 (es) 2002-08-01
IL147162A0 (en) 2002-08-14
BE1013417A6 (fr) 2001-12-04
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
FR2818977A1 (fr) 2002-07-05
GB0105981D0 (en) 2001-05-02
SE0103044L (sv) 2002-06-29
ATE222899T1 (de) 2002-09-15
BG106219A (en) 2002-08-30
KR100430746B1 (ko) 2004-05-10
HU0102818D0 (en) 2001-09-28
CZ293140B6 (cs) 2004-02-18
AU2001100399A4 (en) 2001-11-01
PT1181272E (pt) 2003-01-31
FI108640B (fi) 2002-02-28
CN1366526A (zh) 2002-08-28
AT4368U1 (de) 2001-06-25
SK18472001A3 (sk) 2002-05-09
FR2818977B1 (fr) 2003-12-05
AR029898A1 (es) 2003-07-23
MXPA01013336A (es) 2002-07-09

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