CO4980899A1 - Proceso para la sintesis de los compuestos intermediarios de cloropurina - Google Patents
Proceso para la sintesis de los compuestos intermediarios de cloropurinaInfo
- Publication number
- CO4980899A1 CO4980899A1 CO98059323A CO98059323A CO4980899A1 CO 4980899 A1 CO4980899 A1 CO 4980899A1 CO 98059323 A CO98059323 A CO 98059323A CO 98059323 A CO98059323 A CO 98059323A CO 4980899 A1 CO4980899 A1 CO 4980899A1
- Authority
- CO
- Colombia
- Prior art keywords
- formula
- compound
- synthesis
- salt
- complex
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- JBMBVWROWJGFMG-UHFFFAOYSA-N 2-chloro-7h-purine Chemical class ClC1=NC=C2NC=NC2=N1 JBMBVWROWJGFMG-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 2
- 238000011065 in-situ storage Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000008139 complexing agent Substances 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un proceso para la preparación de un compuesto de la fórmula (I):opcionalmente en la forma de su sal o complejo, el cual comprende hidrolizar un compuesto de la fórmula (IV):en donde P es un grupo protector, en la presencia de un ácido, condensar el producto de la fórmula (V) formado in situ en la presencia de una base con un compuesto de la fórmula (VI)en la cual R representa CHO o H, seguido por el cierre del anillo in situ del compuesto intermedio resultante de la fórmula (VII)en la cual R representa CHO o H, para producir un compuesto de la fórmula (I), el cual se puede hacer reaccionar entonces opcionalmente con un ácido o agente formador de complejos para formar su sal o complejo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9721780.6A GB9721780D0 (en) | 1997-10-14 | 1997-10-14 | Process for the synthesis of chloropurine intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4980899A1 true CO4980899A1 (es) | 2000-11-27 |
Family
ID=10820547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO98059323A CO4980899A1 (es) | 1997-10-14 | 1998-10-13 | Proceso para la sintesis de los compuestos intermediarios de cloropurina |
Country Status (44)
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK284595B6 (sk) * | 1997-11-27 | 2005-07-01 | Lonza Ag | Spôsob výroby (1S,4R)-4-(2-amino-6-chlór-9H-purín-9-yl)-2- cyklopentén-1-metanolu alebo jeho solí |
FR2849030A1 (fr) * | 2002-12-20 | 2004-06-25 | Isochem Sa | Procede de preparation des n-(2-amino-4, 6-dihalogenopyrimidin-5-yl) formamides |
GB0320738D0 (en) | 2003-09-04 | 2003-10-08 | Glaxo Group Ltd | Novel process |
CN100465174C (zh) * | 2006-06-13 | 2009-03-04 | 中国科学院上海有机化学研究所 | 制备光学纯阿巴卡韦的方法 |
KR101109476B1 (ko) * | 2009-06-26 | 2012-01-31 | 현대제철 주식회사 | 실린더 교체용 지그장치 |
PE20160180A1 (es) | 2010-01-27 | 2016-05-04 | Viiv Healthcare Co | Combinaciones de compuestos que comprenden inhibidores de la integrasa de vih y otros agentes terapeuticos. |
CN104672239A (zh) * | 2013-11-26 | 2015-06-03 | 上海迪赛诺化学制药有限公司 | 一种采用一锅法制备阿巴卡韦式v中间体的工艺 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4268672A (en) * | 1977-02-09 | 1981-05-19 | The Regents Of The University Of Minnesota | Adenosine deaminase resistant antiviral purine nucleosides and method of preparation |
JPS6175A (ja) * | 1984-03-06 | 1986-01-06 | ブリストル−マイア−ズ コムパニ− | 神経弛緩剤、1‐フルオロフェニルブチル‐4‐(5‐ハロ‐2‐ピリミジニル)ピペラジン誘導体 |
LU87437A1 (fr) * | 1988-01-20 | 1989-08-30 | Univ Minnesota | Nucleosides dideoxydidehydrocarbocycliques et composition pharmaceutique les contenant |
US5631370A (en) * | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
NZ229453A (en) * | 1988-06-10 | 1991-08-27 | Univ Minnesota & Southern Rese | A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents |
GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
US5126452A (en) * | 1990-04-06 | 1992-06-30 | Glaxo Inc. | Synthesis of purine substituted cyclopentene derivatives |
US5329008A (en) * | 1993-04-07 | 1994-07-12 | Glaxo Inc. | Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone |
GB9402161D0 (en) * | 1994-02-04 | 1994-03-30 | Wellcome Found | Chloropyrimidine intermediates |
SK285229B6 (sk) * | 1997-05-13 | 2006-09-07 | Lonza Ag | Spôsob výroby derivátov (1R,4S)- alebo (1S,4R)-1-amino-4- (hydroxymetyl)-2-cyklopenténu a enantioméru (1R,4S)-N-butyryl-1- amino-4-(hydroxymetyl)-2-cyklopenténu |
-
1997
- 1997-10-14 GB GBGB9721780.6A patent/GB9721780D0/en not_active Ceased
-
1998
- 1998-10-12 PE PE1998000960A patent/PE121899A1/es not_active IP Right Cessation
- 1998-10-13 IN IN1821CA1998 patent/IN184590B/en unknown
- 1998-10-13 AR ARP980105097A patent/AR014921A1/es active IP Right Grant
- 1998-10-13 EG EG124098A patent/EG21730A/xx active
- 1998-10-13 CO CO98059323A patent/CO4980899A1/es unknown
- 1998-10-13 MA MA25292A patent/MA24676A1/fr unknown
- 1998-10-13 ZA ZA9809338A patent/ZA989338B/xx unknown
- 1998-10-13 MY MYPI98004673A patent/MY127470A/en unknown
- 1998-10-14 DE DE69818084T patent/DE69818084T2/de not_active Expired - Lifetime
- 1998-10-14 AT AT98949093T patent/ATE249461T1/de active
- 1998-10-14 HU HU0003984A patent/HUP0003984A3/hu unknown
- 1998-10-14 KR KR1020007003921A patent/KR100543845B1/ko not_active IP Right Cessation
- 1998-10-14 CN CNB988121522A patent/CN1160354C/zh not_active Expired - Lifetime
- 1998-10-14 ES ES98949093T patent/ES2205553T3/es not_active Expired - Lifetime
- 1998-10-14 TW TW087117057A patent/TW436488B/zh not_active IP Right Cessation
- 1998-10-14 CZ CZ20001367A patent/CZ294482B6/cs not_active IP Right Cessation
- 1998-10-14 NZ NZ503679A patent/NZ503679A/xx not_active IP Right Cessation
- 1998-10-14 EP EP98949093A patent/EP1023292B1/en not_active Expired - Lifetime
- 1998-10-14 EA EA200000318A patent/EA003183B1/ru not_active IP Right Cessation
- 1998-10-14 TR TR2000/00976T patent/TR200000976T2/xx unknown
- 1998-10-14 AU AU95476/98A patent/AU738462B2/en not_active Expired
- 1998-10-14 JP JP2000515898A patent/JP4531250B2/ja not_active Expired - Lifetime
- 1998-10-14 SK SK536-2000A patent/SK285331B6/sk not_active IP Right Cessation
- 1998-10-14 IL IL13532398A patent/IL135323A/en not_active IP Right Cessation
- 1998-10-14 DK DK98949093T patent/DK1023292T3/da active
- 1998-10-14 US US09/529,385 patent/US6646125B1/en not_active Expired - Lifetime
- 1998-10-14 WO PCT/GB1998/003080 patent/WO1999019327A1/en active IP Right Grant
- 1998-10-14 CA CA002306958A patent/CA2306958C/en not_active Expired - Lifetime
- 1998-10-14 EE EEP200000162A patent/EE04059B1/xx unknown
- 1998-10-14 UA UA2000031789A patent/UA54550C2/uk unknown
- 1998-10-14 PL PL98339904A patent/PL188477B1/pl unknown
- 1998-10-14 BR BRPI9813048-0A patent/BR9813048B1/pt not_active IP Right Cessation
- 1998-10-14 GE GEAP19985300A patent/GEP20022679B/en unknown
- 1998-10-14 RS YUP-202/00A patent/RS49710B/sr unknown
- 1998-10-14 AP APAP/P/2000/001790A patent/AP1182A/en active
- 1998-10-14 PT PT98949093T patent/PT1023292E/pt unknown
- 1998-10-14 ID IDW20000707A patent/ID24927A/id unknown
-
2000
- 2000-03-28 IS IS5423A patent/IS2195B/is unknown
- 2000-04-07 OA OA1200000101A patent/OA11370A/en unknown
- 2000-04-12 NO NO20001896A patent/NO325030B1/no not_active IP Right Cessation
- 2000-04-14 HR HR980147A patent/HRP20000216B1/xx not_active IP Right Cessation
- 2000-04-18 BG BG104352A patent/BG64597B1/bg unknown
- 2000-11-02 HK HK00106983A patent/HK1027807A1/xx not_active IP Right Cessation
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