TR200000976T2 - Kloropürin ara ürünlerin sentezlenmesi için bir işlem. - Google Patents
Kloropürin ara ürünlerin sentezlenmesi için bir işlem.Info
- Publication number
- TR200000976T2 TR200000976T2 TR2000/00976T TR200000976T TR200000976T2 TR 200000976 T2 TR200000976 T2 TR 200000976T2 TR 2000/00976 T TR2000/00976 T TR 2000/00976T TR 200000976 T TR200000976 T TR 200000976T TR 200000976 T2 TR200000976 T2 TR 200000976T2
- Authority
- TR
- Turkey
- Prior art keywords
- formula
- synthesis
- compound
- chloropurine
- intermediates
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- JBMBVWROWJGFMG-UHFFFAOYSA-N 2-chloro-7h-purine Chemical compound ClC1=NC=C2NC=NC2=N1 JBMBVWROWJGFMG-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- -1 carbocyclic purine nucleoside analog Chemical class 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Bu bulus, formül (I)' e sahip bir karbosiklik pürin nükleosit analogunun, bunun tuzlarinin ve farmasötik olarak kabul edilebilir türevlerinin hazirlanmasi için P' nin bir koruyucu grup oldugu formül (IV)' e sahip bir bilesigin bir asit mevcudiyetinde hidrolize edilmesini, yerinde olusturulan formül (V)' e sahip ürünün, bir baz mevcudiyetinde formül (VI)' ya sahip bir bilesikle yogunlastirilmasini, ardindan elde edilen ara ürünün yerinde halka kapama islemine maruz birakilmasini içeren bir isleme iliskindir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9721780.6A GB9721780D0 (en) | 1997-10-14 | 1997-10-14 | Process for the synthesis of chloropurine intermediates |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200000976T2 true TR200000976T2 (tr) | 2000-11-21 |
Family
ID=10820547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2000/00976T TR200000976T2 (tr) | 1997-10-14 | 1998-10-14 | Kloropürin ara ürünlerin sentezlenmesi için bir işlem. |
Country Status (44)
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK284596B6 (sk) | 1997-11-27 | 2005-07-01 | Lonza Ag | Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purin-9-yl)-2-cyklopentén-1-metanolu alebo jeho solí |
FR2849030A1 (fr) * | 2002-12-20 | 2004-06-25 | Isochem Sa | Procede de preparation des n-(2-amino-4, 6-dihalogenopyrimidin-5-yl) formamides |
GB0320738D0 (en) | 2003-09-04 | 2003-10-08 | Glaxo Group Ltd | Novel process |
CN100465174C (zh) * | 2006-06-13 | 2009-03-04 | 中国科学院上海有机化学研究所 | 制备光学纯阿巴卡韦的方法 |
KR101109476B1 (ko) * | 2009-06-26 | 2012-01-31 | 현대제철 주식회사 | 실린더 교체용 지그장치 |
ES2670811T3 (es) | 2010-01-27 | 2018-06-01 | Viiv Healthcare Company | Terapia antivírica |
CN104672239A (zh) * | 2013-11-26 | 2015-06-03 | 上海迪赛诺化学制药有限公司 | 一种采用一锅法制备阿巴卡韦式v中间体的工艺 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4268672A (en) * | 1977-02-09 | 1981-05-19 | The Regents Of The University Of Minnesota | Adenosine deaminase resistant antiviral purine nucleosides and method of preparation |
JPS6175A (ja) * | 1984-03-06 | 1986-01-06 | ブリストル−マイア−ズ コムパニ− | 神経弛緩剤、1‐フルオロフェニルブチル‐4‐(5‐ハロ‐2‐ピリミジニル)ピペラジン誘導体 |
NZ227663A (en) | 1988-01-20 | 1990-09-26 | Univ Minnesota | Purine nucleoside analogues, pyrimidine derivatives and pharmaceutical compositions |
US5631370A (en) * | 1988-01-20 | 1997-05-20 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
NZ229453A (en) * | 1988-06-10 | 1991-08-27 | Univ Minnesota & Southern Rese | A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents |
GB8815265D0 (en) * | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
US5126452A (en) * | 1990-04-06 | 1992-06-30 | Glaxo Inc. | Synthesis of purine substituted cyclopentene derivatives |
US5329008A (en) * | 1993-04-07 | 1994-07-12 | Glaxo Inc. | Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone |
GB9402161D0 (en) * | 1994-02-04 | 1994-03-30 | Wellcome Found | Chloropyrimidine intermediates |
SK285228B6 (sk) * | 1997-05-13 | 2006-09-07 | Lonza Ag | Spôsob výroby racemického alebo opticky aktívnehoderivátu 4-(hydroxymetyl)-2-cyklopenténu a racemicky N-butyryl-1-amino-4- (hydroxymetyl)-2-cyklopentén |
-
1997
- 1997-10-14 GB GBGB9721780.6A patent/GB9721780D0/en not_active Ceased
-
1998
- 1998-10-12 PE PE1998000960A patent/PE121899A1/es not_active IP Right Cessation
- 1998-10-13 MA MA25292A patent/MA24676A1/fr unknown
- 1998-10-13 CO CO98059323A patent/CO4980899A1/es unknown
- 1998-10-13 ZA ZA9809338A patent/ZA989338B/xx unknown
- 1998-10-13 MY MYPI98004673A patent/MY127470A/en unknown
- 1998-10-13 EG EG124098A patent/EG21730A/xx active
- 1998-10-13 IN IN1821CA1998 patent/IN184590B/en unknown
- 1998-10-13 AR ARP980105097A patent/AR014921A1/es active IP Right Grant
- 1998-10-14 AU AU95476/98A patent/AU738462B2/en not_active Expired
- 1998-10-14 EP EP98949093A patent/EP1023292B1/en not_active Expired - Lifetime
- 1998-10-14 RS YUP-202/00A patent/RS49710B/sr unknown
- 1998-10-14 ES ES98949093T patent/ES2205553T3/es not_active Expired - Lifetime
- 1998-10-14 ID IDW20000707A patent/ID24927A/id unknown
- 1998-10-14 AT AT98949093T patent/ATE249461T1/de active
- 1998-10-14 GE GEAP19985300A patent/GEP20022679B/en unknown
- 1998-10-14 DK DK98949093T patent/DK1023292T3/da active
- 1998-10-14 SK SK536-2000A patent/SK285331B6/sk not_active IP Right Cessation
- 1998-10-14 BR BRPI9813048-0A patent/BR9813048B1/pt not_active IP Right Cessation
- 1998-10-14 IL IL13532398A patent/IL135323A/en not_active IP Right Cessation
- 1998-10-14 DE DE69818084T patent/DE69818084T2/de not_active Expired - Lifetime
- 1998-10-14 JP JP2000515898A patent/JP4531250B2/ja not_active Expired - Lifetime
- 1998-10-14 PL PL98339904A patent/PL188477B1/pl unknown
- 1998-10-14 US US09/529,385 patent/US6646125B1/en not_active Expired - Lifetime
- 1998-10-14 NZ NZ503679A patent/NZ503679A/xx not_active IP Right Cessation
- 1998-10-14 CZ CZ20001367A patent/CZ294482B6/cs not_active IP Right Cessation
- 1998-10-14 EA EA200000318A patent/EA003183B1/ru not_active IP Right Cessation
- 1998-10-14 WO PCT/GB1998/003080 patent/WO1999019327A1/en active IP Right Grant
- 1998-10-14 PT PT98949093T patent/PT1023292E/pt unknown
- 1998-10-14 TR TR2000/00976T patent/TR200000976T2/tr unknown
- 1998-10-14 CA CA002306958A patent/CA2306958C/en not_active Expired - Lifetime
- 1998-10-14 KR KR1020007003921A patent/KR100543845B1/ko not_active IP Right Cessation
- 1998-10-14 TW TW087117057A patent/TW436488B/zh not_active IP Right Cessation
- 1998-10-14 CN CNB988121522A patent/CN1160354C/zh not_active Expired - Lifetime
- 1998-10-14 UA UA2000031789A patent/UA54550C2/uk unknown
- 1998-10-14 AP APAP/P/2000/001790A patent/AP1182A/en active
- 1998-10-14 EE EEP200000162A patent/EE04059B1/xx unknown
- 1998-10-14 HU HU0003984A patent/HUP0003984A3/hu unknown
-
2000
- 2000-03-28 IS IS5423A patent/IS2195B/is unknown
- 2000-04-07 OA OA1200000101A patent/OA11370A/en unknown
- 2000-04-12 NO NO20001896A patent/NO325030B1/no not_active IP Right Cessation
- 2000-04-14 HR HR980147A patent/HRP20000216B1/xx not_active IP Right Cessation
- 2000-04-18 BG BG104352A patent/BG64597B1/bg unknown
- 2000-11-02 HK HK00106983A patent/HK1027807A1/xx not_active IP Right Cessation
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