EE04059B1 - Kloropuriinvaheühendite sünteesimeetod - Google Patents

Kloropuriinvaheühendite sünteesimeetod

Info

Publication number
EE04059B1
EE04059B1 EEP200000162A EEP200000162A EE04059B1 EE 04059 B1 EE04059 B1 EE 04059B1 EE P200000162 A EEP200000162 A EE P200000162A EE P200000162 A EEP200000162 A EE P200000162A EE 04059 B1 EE04059 B1 EE 04059B1
Authority
EE
Estonia
Prior art keywords
synthesis
chloropurine
intermediates
chloropurine intermediates
Prior art date
Application number
EEP200000162A
Other languages
English (en)
Estonian (et)
Inventor
Francis Jones Martin
John Wallis Christopher
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of EE200000162A publication Critical patent/EE200000162A/xx
Publication of EE04059B1 publication Critical patent/EE04059B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
EEP200000162A 1997-10-14 1998-10-14 Kloropuriinvaheühendite sünteesimeetod EE04059B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9721780.6A GB9721780D0 (en) 1997-10-14 1997-10-14 Process for the synthesis of chloropurine intermediates
PCT/GB1998/003080 WO1999019327A1 (en) 1997-10-14 1998-10-14 Process for the synthesis of chloropurine intermediates

Publications (2)

Publication Number Publication Date
EE200000162A EE200000162A (et) 2001-04-16
EE04059B1 true EE04059B1 (et) 2003-06-16

Family

ID=10820547

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000162A EE04059B1 (et) 1997-10-14 1998-10-14 Kloropuriinvaheühendite sünteesimeetod

Country Status (44)

Country Link
US (1) US6646125B1 (xx)
EP (1) EP1023292B1 (xx)
JP (1) JP4531250B2 (xx)
KR (1) KR100543845B1 (xx)
CN (1) CN1160354C (xx)
AP (1) AP1182A (xx)
AR (1) AR014921A1 (xx)
AT (1) ATE249461T1 (xx)
AU (1) AU738462B2 (xx)
BG (1) BG64597B1 (xx)
BR (1) BR9813048B1 (xx)
CA (1) CA2306958C (xx)
CO (1) CO4980899A1 (xx)
CZ (1) CZ294482B6 (xx)
DE (1) DE69818084T2 (xx)
DK (1) DK1023292T3 (xx)
EA (1) EA003183B1 (xx)
EE (1) EE04059B1 (xx)
EG (1) EG21730A (xx)
ES (1) ES2205553T3 (xx)
GB (1) GB9721780D0 (xx)
GE (1) GEP20022679B (xx)
HK (1) HK1027807A1 (xx)
HR (1) HRP20000216B1 (xx)
HU (1) HUP0003984A3 (xx)
ID (1) ID24927A (xx)
IL (1) IL135323A (xx)
IN (1) IN184590B (xx)
IS (1) IS2195B (xx)
MA (1) MA24676A1 (xx)
MY (1) MY127470A (xx)
NO (1) NO325030B1 (xx)
NZ (1) NZ503679A (xx)
OA (1) OA11370A (xx)
PE (1) PE121899A1 (xx)
PL (1) PL188477B1 (xx)
PT (1) PT1023292E (xx)
RS (1) RS49710B (xx)
SK (1) SK285331B6 (xx)
TR (1) TR200000976T2 (xx)
TW (1) TW436488B (xx)
UA (1) UA54550C2 (xx)
WO (1) WO1999019327A1 (xx)
ZA (1) ZA989338B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK284594B6 (sk) 1997-11-27 2005-07-01 Lonza Ag Spôsob výroby derivátov aminoalkoholov a ich soli
FR2849030A1 (fr) * 2002-12-20 2004-06-25 Isochem Sa Procede de preparation des n-(2-amino-4, 6-dihalogenopyrimidin-5-yl) formamides
GB0320738D0 (en) * 2003-09-04 2003-10-08 Glaxo Group Ltd Novel process
CN100465174C (zh) * 2006-06-13 2009-03-04 中国科学院上海有机化学研究所 制备光学纯阿巴卡韦的方法
KR101109476B1 (ko) * 2009-06-26 2012-01-31 현대제철 주식회사 실린더 교체용 지그장치
TR201807704T4 (tr) 2010-01-27 2018-06-21 Viiv Healthcare Co Anti-viral tedavi.
CN104672239A (zh) * 2013-11-26 2015-06-03 上海迪赛诺化学制药有限公司 一种采用一锅法制备阿巴卡韦式v中间体的工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268672A (en) * 1977-02-09 1981-05-19 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
JPS6175A (ja) * 1984-03-06 1986-01-06 ブリストル−マイア−ズ　コムパニ− 神経弛緩剤、１‐フルオロフェニルブチル‐４‐（５‐ハロ‐２‐ピリミジニル）ピペラジン誘導体
IL88999A (en) * 1988-01-20 1994-12-29 Univ Minnesota Carbocyclic history of 2D (3-deoxy- (2T) (3D) -Didhydro furin nucleoside and pharmaceutical preparations containing them
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
NZ229453A (en) * 1988-06-10 1991-08-27 Univ Minnesota & Southern Rese A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
US5126452A (en) * 1990-04-06 1992-06-30 Glaxo Inc. Synthesis of purine substituted cyclopentene derivatives
US5329008A (en) * 1993-04-07 1994-07-12 Glaxo Inc. Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
SK284810B6 (sk) * 1997-05-13 2005-12-01 Lonza Ag Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu

Also Published As

Publication number Publication date
EG21730A (en) 2002-02-27
YU20200A (sh) 2003-02-28
PL188477B1 (pl) 2005-02-28
AR014921A1 (es) 2001-04-11
BR9813048A (pt) 2000-08-15
IL135323A0 (en) 2001-05-20
PE121899A1 (es) 1999-12-20
CZ20001367A3 (cs) 2000-10-11
IS5423A (is) 2000-03-28
CZ294482B6 (cs) 2005-01-12
RS49710B (sr) 2007-12-31
JP2001519432A (ja) 2001-10-23
CN1281457A (zh) 2001-01-24
HRP20000216B1 (en) 2002-08-31
ID24927A (id) 2000-08-31
ZA989338B (en) 2000-04-13
BR9813048B1 (pt) 2010-07-13
BG104352A (en) 2001-02-28
AU9547698A (en) 1999-05-03
MY127470A (en) 2006-12-29
EA200000318A1 (ru) 2000-12-25
OA11370A (en) 2004-01-27
SK285331B6 (sk) 2006-11-03
PL339904A1 (en) 2001-01-15
DE69818084D1 (de) 2003-10-16
NZ503679A (en) 2002-09-27
HUP0003984A3 (en) 2002-12-28
CA2306958C (en) 2007-09-04
CA2306958A1 (en) 1999-04-22
DK1023292T3 (da) 2003-11-10
SK5362000A3 (en) 2001-03-12
WO1999019327A1 (en) 1999-04-22
HRP20000216A2 (en) 2000-08-31
TR200000976T2 (tr) 2000-11-21
NO20001896D0 (no) 2000-04-12
CO4980899A1 (es) 2000-11-27
EA003183B1 (ru) 2003-02-27
AP2000001790A0 (en) 2000-06-30
JP4531250B2 (ja) 2010-08-25
AU738462B2 (en) 2001-09-20
GEP20022679B (en) 2002-04-25
HUP0003984A2 (hu) 2001-04-28
IS2195B (is) 2007-01-15
MA24676A1 (fr) 1999-07-01
TW436488B (en) 2001-05-28
NO20001896L (no) 2000-06-13
US6646125B1 (en) 2003-11-11
EE200000162A (et) 2001-04-16
EP1023292A1 (en) 2000-08-02
CN1160354C (zh) 2004-08-04
KR20010015744A (ko) 2001-02-26
DE69818084T2 (de) 2004-07-15
IL135323A (en) 2004-07-25
NO325030B1 (no) 2008-01-21
KR100543845B1 (ko) 2006-01-23
UA54550C2 (uk) 2003-03-17
GB9721780D0 (en) 1997-12-10
ATE249461T1 (de) 2003-09-15
EP1023292B1 (en) 2003-09-10
IN184590B (xx) 2000-09-09
HK1027807A1 (en) 2001-01-23
ES2205553T3 (es) 2004-05-01
AP1182A (en) 2003-06-18
PT1023292E (pt) 2004-02-27
BG64597B1 (bg) 2005-08-31

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231