KR890000425A - 피페리디닐시클로펜틸헵텐산 유도체의 제조방법 - Google Patents

피페리디닐시클로펜틸헵텐산 유도체의 제조방법 Download PDF

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Publication number
KR890000425A
KR890000425A KR1019880007895A KR880007895A KR890000425A KR 890000425 A KR890000425 A KR 890000425A KR 1019880007895 A KR1019880007895 A KR 1019880007895A KR 880007895 A KR880007895 A KR 880007895A KR 890000425 A KR890000425 A KR 890000425A
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South Korea
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group
salt
formula
compound
general formula
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KR1019880007895A
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English (en)
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밀스 케이쓰
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베리 에이 뉴샘
글락소 그튬 리미티드
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Publication of KR890000425A publication Critical patent/KR890000425A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

피페리디닐시클로펜틸헵텐산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(2)의 화합물 또는 그 염의 A부분을 페닐기로 치환시킨후, 이어서 필요에 따라서 C1-6알킬 또는 C7-20아랄킬 보호기를 제거시키고(또는) 염을 생성시키는 것으로 되는 하기 일반식(1)로 표시되는 화합물의 제조방법.
    상기식중, A는 치환될 수 있는 원자 또는 기이고, R은 수소 원자 또는 C1-6알킬 또는 C7-20아랄킬 보호기이다.
  2. 제1항에 있어서, 페닐기에 의한 일반식(2)에서의 A부분의 치환을 하기 일반식(3)의 화합물을 사용하여 행하는 방법.
    PhX (3)
    상기식중, Ph는 페닐기이고, X는 제1항에서 A에 대하여 정의한 바와같은 원자 또는 기이거나, 또는 Li, Cu, MgHal, ZnHal, HgHal, SnR3′또는 SiR3′(여기에서, Hal은 할로겐 원자이고, R′은 C1-6알킬기 또는 아릴기임)중에서 선택된 원자 또는 기이되, 단 일반식(2)에서 A가 -B(OH)2기인 경우에, 일반식(3)의 X는 단지 통상적인 이탈기만을 나타낼 수 있다.
  3. 제2항에 있어서, A와 X중 어느 하나가 할로겐원자이고, 다른 하나는 -B(OH)2기인 일반식(2)와 (3)의 화합물을 반응시키는 방법.
  4. 제3항에 있어서, 커플링 반응을 염기를 함유한 용매 중에서 전이 금속 촉매 존재하에 행하는 방법.
  5. 제4항에 있어서, 전이 금속 촉매가 (Ph3)4Pd인 방법.
  6. 제4항 또는 제5항에 있어서, 용매가 에테르인 방법.
  7. 제4항 내지 제6항중 임의의 항에 있어서, 염기가 탄산 나트륨 수용액인 방법.
  8. 제1항에 있어서, (i) A가 치환될 수 있는 원자 또는 기이고 R이 C1-6알킬기이거나 또는 C7-20아랄킬인 일반식(2)의 화합물 또는 그 염의 A부분을 페닐기로 치환시켜서 하기 일반식(5)의 에스테르 또는 그의 염을 생성시키는 단계와, (ii)이 에스테르(5) 또는 그의 염을 가수분해시켜서 일반식(1)의 산을 얻고, 이 산을 임의로 처리하여 그의 염을 얻는 단계로 되는 방법.
    상기식중, R은 C1-6알킬 또는 C7-20아랄킬이다.
  9. 제1항에서 정의된 일반식(2)의 화합물 및 그의 염.
  10. A가 할로겐 원자 또는 -B(OH)2기인 제9항에서 정의된 화합물 및 그의 염.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880007895A 1987-06-30 1988-06-29 피페리디닐시클로펜틸헵텐산 유도체의 제조방법 KR890000425A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878715333A GB8715333D0 (en) 1987-06-30 1987-06-30 Process
GB8715333 1987-06-30

Publications (1)

Publication Number Publication Date
KR890000425A true KR890000425A (ko) 1989-03-14

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ID=10619818

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880007895A KR890000425A (ko) 1987-06-30 1988-06-29 피페리디닐시클로펜틸헵텐산 유도체의 제조방법

Country Status (15)

Country Link
US (1) US4933461A (ko)
EP (1) EP0297853A1 (ko)
JP (1) JPS6422864A (ko)
KR (1) KR890000425A (ko)
AU (1) AU615922B2 (ko)
CA (1) CA1312609C (ko)
DK (1) DK357388A (ko)
FI (1) FI883105A (ko)
GB (1) GB8715333D0 (ko)
IL (2) IL86548A0 (ko)
NO (1) NO882883L (ko)
NZ (1) NZ225221A (ko)
PH (1) PH24774A (ko)
PT (1) PT87861B (ko)
ZA (1) ZA884649B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE509731C2 (sv) * 1996-05-14 1999-03-01 Labwell Ab Metod för palladium-katalyserade organiska reaktioner innefattande ett uppvärmningssteg utfört med mikrovågsenergi
US5892131A (en) * 1997-05-29 1999-04-06 American Cyanamid Company Process for the preparation of pesticidal fluoroolefin compounds
ZA974582B (en) * 1996-06-03 1998-11-26 American Cyanamid Co Process and intermediate compounds for the preparation of pesticidal fluoroolefin compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU542949B2 (en) * 1980-01-09 1985-03-28 Glaxo Group Limited Prostanoid compounds
JPS5718671A (en) * 1980-04-30 1982-01-30 Glaxo Group Ltd Aminocyclopentane alkenoic acid and esters thereof,manufacture and drug composition
JPS57183772A (en) * 1981-04-29 1982-11-12 Glaxo Group Ltd Aminocyclopentanol acids and esters, manufacture and medicinal composition
GB2127406B (en) * 1982-09-16 1986-03-05 Glaxo Group Ltd Piperidinlycyclopentanolheptenoic acid salt
CA1191136A (en) * 1982-10-28 1985-07-30 Ian Waterhouse Preparation of aminocyclopentane acids
GB8601985D0 (en) * 1986-01-28 1986-03-05 Glaxo Group Ltd Chemical process
JPS6422863A (en) * 1987-06-22 1989-01-25 Glaxo Group Ltd Aminocyclopentyl ether, manufacture and medicinal composition

Also Published As

Publication number Publication date
FI883105A (fi) 1988-12-31
DK357388D0 (da) 1988-06-29
NO882883D0 (no) 1988-06-29
IL86548A0 (en) 1988-11-15
EP0297853A1 (en) 1989-01-04
NO882883L (no) 1989-01-02
AU1873388A (en) 1989-01-05
GB8715333D0 (en) 1987-08-05
PH24774A (en) 1990-10-30
JPS6422864A (en) 1989-01-25
FI883105A0 (fi) 1988-06-29
PT87861A (pt) 1988-07-01
IL86930A0 (en) 1988-11-30
CA1312609C (en) 1993-01-12
PT87861B (pt) 1992-11-30
US4933461A (en) 1990-06-12
DK357388A (da) 1988-12-31
IL86930A (en) 1992-07-15
ZA884649B (en) 1989-03-29
NZ225221A (en) 1990-10-26
AU615922B2 (en) 1991-10-17

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