ES8300734A1 - Un procedimiento para la preparacion de derivados de acidos fenil-alcanoicos. - Google Patents

Un procedimiento para la preparacion de derivados de acidos fenil-alcanoicos.

Info

Publication number
ES8300734A1
ES8300734A1 ES82508805A ES508805A ES8300734A1 ES 8300734 A1 ES8300734 A1 ES 8300734A1 ES 82508805 A ES82508805 A ES 82508805A ES 508805 A ES508805 A ES 508805A ES 8300734 A1 ES8300734 A1 ES 8300734A1
Authority
ES
Spain
Prior art keywords
formula
processes
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES82508805A
Other languages
English (en)
Other versions
ES508805A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8300734A1 publication Critical patent/ES8300734A1/es
Publication of ES508805A0 publication Critical patent/ES508805A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/18—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted otherwise than in position 3 or 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/40—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with ozone; by ozonolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE ACIDOS FENILALCANOICOS, DE FORMULA (I), EN LA QUE R ES HIDROGENO, ALQUILO INFERIO O ACILO, R ES ALQUILENO O ALQUENILENO INFERIOR; X ES O, S, SO O SO ; Y R PUEDE SER VARIOS RADICALES. CONSISTE EN LA REACCION DE HIDROLISIS DE UN COMPUESTO DE FORMULA (II) O SU SAL, EN LA QUE R , R , R Y X TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO, TAL COMO METANOL O ETANOL, O EN AGUA, EN PRESENCIA DE UNA BASE, COMO HIDROXIDO SODICO O POTASICO, O DE UN ACIDO, COMO CLORHIDRICO O ACETICO, CON CALEFACCION SUAVE O FUERTE. >ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES ANTIINFLAMATORIAS, ANALGESICAS Y ANTIPIRETICAS.
ES82508805A 1980-01-28 1982-01-15 Un procedimiento para la preparacion de derivados de acidos fenil-alcanoicos. Granted ES508805A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8002790 1980-01-28
GB8039308 1980-12-08

Publications (2)

Publication Number Publication Date
ES8300734A1 true ES8300734A1 (es) 1982-11-16
ES508805A0 ES508805A0 (es) 1982-11-16

Family

ID=26274313

Family Applications (2)

Application Number Title Priority Date Filing Date
ES82508805A Granted ES508805A0 (es) 1980-01-28 1982-01-15 Un procedimiento para la preparacion de derivados de acidos fenil-alcanoicos.
ES508806A Granted ES508806A0 (es) 1980-01-28 1982-01-15 Un procedimiento para la preparacion de derivados de acidos fenil-alcanoicos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES508806A Granted ES508806A0 (es) 1980-01-28 1982-01-15 Un procedimiento para la preparacion de derivados de acidos fenil-alcanoicos.

Country Status (10)

Country Link
US (1) US4367238A (es)
EP (1) EP0033614B1 (es)
AR (1) AR228586A1 (es)
AT (1) ATE7782T1 (es)
AU (1) AU537560B2 (es)
CA (1) CA1195691A (es)
DE (1) DE3162626D1 (es)
DK (1) DK34781A (es)
ES (2) ES508805A0 (es)
GR (1) GR73505B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3110009A1 (de) * 1981-03-11 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue benzofuran-derivate, ihre herstellung und verwendung
US4857455A (en) * 1982-11-26 1989-08-15 Syntex (U.S.A) Inc. Method for the determination of peroxidase using fluorogenic substrates
GB8328253D0 (en) * 1983-10-21 1983-11-23 Shell Int Research Substituted azetidine derivatives
US4911754A (en) * 1987-07-16 1990-03-27 American Cyanamid Company Herbicidally active aryloxy saturated 5-membered benzo fused hetero-cyclic compounds
US6001877A (en) * 1989-06-27 1999-12-14 Ono Pharmaceutical Co., Ltd. Phenylalkan(en)oic acid
US5256686A (en) * 1989-06-27 1993-10-26 Ono Pharmaceutical Co., Ltd. Phenylalkan(en)oic acid
ES2163986B1 (es) * 1999-07-13 2003-02-16 Menarini Lab Acidos-alfa-arilpropionicos y arilaceticos como inhibidores de la ciclooxigenasa-ii.
WO2001049648A1 (en) * 2000-01-04 2001-07-12 Korea Research Institute Of Chemical Technology Preparing method of 2-phenylalkanoic acid derivatives
EP1366763A1 (en) * 2002-05-28 2003-12-03 Ciba SC Holding AG Hydroxy diphenyl ether compounds as anti-inflammatory agents
EP1481959A1 (de) * 2003-05-22 2004-12-01 DSM Fine Chemicals Austria Nfg GmbH & Co KG Verfahren zur Herstellung von Lactonen und von aromatischen Hydroxycarbonsäuren
GB201118876D0 (en) * 2011-11-01 2011-12-14 Astex Therapeutics Ltd Pharmaceutical compounds
EP3036222A2 (en) * 2013-08-23 2016-06-29 Virginia Commonwealth University Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838522A (en) * 1956-04-30 1958-06-10 Dow Chemical Co Phthalides
SE363818B (es) * 1968-08-15 1974-02-04 Lilly Co Eli
US4120871A (en) * 1975-05-06 1978-10-17 Fisons Limited 5-Organosulfonyl, 5-organosulfinyl or 5-haloalkanoyl-benzofuran-2-ones

Also Published As

Publication number Publication date
AU537560B2 (en) 1984-06-28
AR228586A1 (es) 1983-03-30
EP0033614B1 (en) 1984-06-06
ES8300735A1 (es) 1982-11-16
DE3162626D1 (en) 1984-07-12
DK34781A (da) 1981-07-29
US4367238A (en) 1983-01-04
GR73505B (es) 1984-03-06
ATE7782T1 (de) 1984-06-15
CA1195691A (en) 1985-10-22
EP0033614A1 (en) 1981-08-12
ES508806A0 (es) 1982-11-16
ES508805A0 (es) 1982-11-16
AU6668781A (en) 1981-08-06

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