ES8106296A1 - Un procedimiento para la preparacion de fenil-quinolicidinas - Google Patents

Un procedimiento para la preparacion de fenil-quinolicidinas

Info

Publication number
ES8106296A1
ES8106296A1 ES493200A ES493200A ES8106296A1 ES 8106296 A1 ES8106296 A1 ES 8106296A1 ES 493200 A ES493200 A ES 493200A ES 493200 A ES493200 A ES 493200A ES 8106296 A1 ES8106296 A1 ES 8106296A1
Authority
ES
Spain
Prior art keywords
lower alkyl
formula
acid
reaction
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493200A
Other languages
English (en)
Other versions
ES493200A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8106296A1 publication Critical patent/ES8106296A1/es
Publication of ES493200A0 publication Critical patent/ES493200A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16D—COUPLINGS FOR TRANSMITTING ROTATION; CLUTCHES; BRAKES
    • F16D65/00—Parts or details
    • F16D65/14—Actuating mechanisms for brakes; Means for initiating operation at a predetermined position
    • F16D65/16—Actuating mechanisms for brakes; Means for initiating operation at a predetermined position arranged in or on the brake
    • F16D65/22—Actuating mechanisms for brakes; Means for initiating operation at a predetermined position arranged in or on the brake adapted for pressing members apart, e.g. for drum brakes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16D—COUPLINGS FOR TRANSMITTING ROTATION; CLUTCHES; BRAKES
    • F16D65/00—Parts or details
    • F16D65/38—Slack adjusters
    • F16D65/40—Slack adjusters mechanical
    • F16D65/52—Slack adjusters mechanical self-acting in one direction for adjusting excessive play

Landscapes

  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

METODO DE PREPARACION DE FENIL-QUINOLICIDINAS DE FORMULA (I), DONDE X E Y SON HIDROGENO, FLUOR, CLORO, ALCOXILO INFERIOR O ALQUILO INFERIOR; R2 ES ALQUILO INFERIOR, FENILO OPCIONALMENTE SUSTITUIDO POR HALOGENO, ALCOXILO INFERIOR O TRIFLUOROMETILO Y R7 ES ALQUILO INFERIOR O ACILO. SE OBTIENE EL COMPUESTO MEDIANTE LA REACCION DE UN ALCOHOL DE FORMULA (II) CON ALGUN AGENTE ESTERIFICANTE O ETERIFICANTE QUE CEDA EL GRUPO R7, TAL COMO EL ANHIDRIDO DE ACIDO DE FORMULA (III) EN PRESENCIA DE PIRIDINA, O EL ESTER ISOPROPENILICO DE FORMULA (IV) EN PRESENCIA DE ACIDO P-TOLUENSULFONICO, O UN HALURO DE ALQUILO INFERIOR. OPCIONALMENTE SE DISOCIA EL RACEMATO OBTENIDO O SE OBTIENE, MEDIANTE REACCION CON UN ACIDO ADECUADO, LA SAL DE ADICION DE ACIDO. DE APLICACION COMO ANTIPSICOTICOS, ANTIEMETICOS O ANALGESICOS EN EL CONTROL DE PSICOSIS Y NEUROSIS, NAUSEAS O DOLOR. *FORMULA* D
ES493200A 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas Granted ES493200A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1065478 1978-10-13

Publications (2)

Publication Number Publication Date
ES8106296A1 true ES8106296A1 (es) 1981-06-16
ES493200A0 ES493200A0 (es) 1981-06-16

Family

ID=4365438

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493200A Granted ES493200A0 (es) 1978-10-13 1980-07-08 Un procedimiento para la preparacion de fenil-quinolicidinas

Country Status (5)

Country Link
JP (1) JPS5553289A (es)
KR (3) KR830001667B1 (es)
CS (1) CS241024B2 (es)
ES (1) ES493200A0 (es)
ZA (1) ZA795318B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2726221B2 (ja) * 1993-05-21 1998-03-11 不二精機株式会社 洗米器
CA2710006A1 (en) * 2007-12-19 2009-06-25 55Pharma Drug Discovery & Development Ag Octahydroquinoli zines for antidiabetic treatment
US8143273B2 (en) * 2010-06-22 2012-03-27 Hoffman-La Roche Inc. Quinolizidine and indolizidine derivatives

Also Published As

Publication number Publication date
ZA795318B (en) 1980-09-24
KR830001667B1 (ko) 1983-08-23
JPS5553289A (en) 1980-04-18
KR830001839B1 (en) 1983-09-14
KR830001838B1 (ko) 1983-09-14
ES493200A0 (es) 1981-06-16
CS686179A2 (en) 1985-06-13
CS241024B2 (en) 1986-03-13
KR830001281A (ko) 1983-04-30

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