KR840005070A - 아미노알카디엔 유도체의 제조방법 - Google Patents

아미노알카디엔 유도체의 제조방법 Download PDF

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Publication number
KR840005070A
KR840005070A KR1019830002131A KR830002131A KR840005070A KR 840005070 A KR840005070 A KR 840005070A KR 1019830002131 A KR1019830002131 A KR 1019830002131A KR 830002131 A KR830002131 A KR 830002131A KR 840005070 A KR840005070 A KR 840005070A
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KR
South Korea
Prior art keywords
amino
salt
hepta
dienoic acid
derivative
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KR1019830002131A
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English (en)
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KR900006127B1 (ko
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자뀌 캐사라 빼뜨릭
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삐에르 쥴리앙
메렐 토라우드 엘 캄파니
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Publication of KR900006127B1 publication Critical patent/KR900006127B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

내용 없음

Description

아미노알카디엔 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 다음 일반식 (I)의 (S)- 또는 (R,S)-아미노알킨 화합물의 아미노-보호된 유도체에서 에티닐 그룹을 알레닐 그룹으로 전환시킴을 특징으로 하여, (R,S)-4-아미노-헵타-5,6-디에노산, (S)-4-아미노-헵타-5,6-디에노산 또는 이들의 약제학적으로 무독한 염을 제조하는 방법.
    상기식에서, R은 C1내지 C4알킬이다.
  2. 제1항에 있어서, 전환반응을 무기염 존재하의 유기용매중에서 상술한 아미노-보호된 유도체를 포름알데히드 및 α-탄소원자상에 수소원자를 갖는 2급 아민과 함께 가열하여 수행하는 방법.
  3. 제2항에 있어서, 2급 아민이 디이소프로필아민이며, 무기염이 구리염인 방법.
  4. 제1항 내지 3항중의 어느 하나에 있어서, 일반식 (I)의 반응물이 (S)-이성체이고, 생성물이(S)-4-아미노-헵타-5,6-디에노산 또는 그의 염인 방법.
  5. 제1항 내지 3항중의 어느 하나에 있어서, 일반식 (I)의 반응물이 (R,S)-라세미체이고, 생성된(R,S)-4-아미노-헵타-5,6-디에노산 또는 그의 염을 광학적으로 단리시켜 (S)-이성체를 수득하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002131A 1982-05-17 1983-05-16 아미노알카디엔 유도체의 제조방법 KR900006127B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8214290 1982-05-17
GB8214290 1982-05-17

Publications (2)

Publication Number Publication Date
KR840005070A true KR840005070A (ko) 1984-11-03
KR900006127B1 KR900006127B1 (ko) 1990-08-24

Family

ID=10530399

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002131A KR900006127B1 (ko) 1982-05-17 1983-05-16 아미노알카디엔 유도체의 제조방법

Country Status (18)

Country Link
US (1) US4454156A (ko)
EP (1) EP0094886B1 (ko)
JP (1) JPS58208255A (ko)
KR (1) KR900006127B1 (ko)
AT (1) ATE14216T1 (ko)
AU (1) AU555635B2 (ko)
CA (1) CA1196656A (ko)
DE (1) DE3360386D1 (ko)
DK (1) DK164661C (ko)
ES (1) ES522436A0 (ko)
GB (1) GB2120244B (ko)
GR (1) GR77487B (ko)
IE (1) IE54819B1 (ko)
IL (1) IL68525A (ko)
NO (1) NO164021C (ko)
NZ (1) NZ204017A (ko)
PH (1) PH22652A (ko)
ZA (1) ZA833012B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311804D0 (en) * 1983-04-29 1983-06-02 Merrell Toraude & Co Treatment of seizure disorders and pharmaceutical compositions
NZ208805A (en) * 1983-07-07 1989-01-27 Syntex Inc #q#-allenic-substituted amino acids and pharmaceutical compositions
US4668703A (en) * 1983-07-07 1987-05-26 Syntex (U.S.A.) Inc. γ-allenyl-γ-aminobutyric acids
EP0134561B1 (en) * 1983-08-17 1987-07-08 Syntex (U.S.A.) Inc. Alpha-allenic-alpha-amino acids
JPS62148462A (ja) * 1985-12-19 1987-07-02 メレルダウフア−マス−テイカルズ　インコ−ポレ−テツド 原生動物の生長を抑制する新規な方法
US5196450A (en) * 1985-12-19 1993-03-23 Merrell Dow Pharmaceuticals Inc. Method of inhibiting protozoal growth
AU644919B2 (en) * 1990-12-17 1993-12-23 Aventisub Ii Inc. Process for the production of (S)-vinyl and allenyl gaba
US5208345A (en) * 1990-12-17 1993-05-04 Merrell Dow Pharmaceuticals Inc. Process for the production of (S)-vinyl and allenyl gaba
US5316944A (en) * 1992-07-17 1994-05-31 Merrell Dow Pharmaceuticals Enzymatic resolution of a racemic mixture of gamma-amino acids using penicillin acylase
ES2114199T3 (es) * 1993-06-23 1998-05-16 Merrell Pharma Inc Nuevos procedimientos para preparar acido (s)-4-amino-hepta-5,6-dienoico e intermediarios del mismo.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960927A (en) * 1975-03-18 1976-06-01 Richardson-Merrell Inc. Olefinic derivatives of amino acids
US4326071A (en) * 1977-09-28 1982-04-20 Merrell Toraude Et Compagnie Halomethyl derivatives of gamma-aminobutyric acid and related compounds
US4178463A (en) * 1978-01-30 1979-12-11 Merrell Toraude Et Compagnie Process for making 4-aminohex-5-enoic acid

Also Published As

Publication number Publication date
GB2120244A (en) 1983-11-30
GB2120244B (en) 1985-05-01
JPH0465056B2 (ko) 1992-10-16
ES8406415A1 (es) 1984-08-16
EP0094886B1 (en) 1985-07-10
ES522436A0 (es) 1984-08-16
PH22652A (en) 1988-10-28
DK164661B (da) 1992-07-27
EP0094886A1 (en) 1983-11-23
US4454156A (en) 1984-06-12
DK218083A (da) 1983-11-18
GB8311234D0 (en) 1983-06-02
ATE14216T1 (de) 1985-07-15
IE54819B1 (en) 1990-02-14
NO164021B (no) 1990-05-14
AU555635B2 (en) 1986-10-02
IL68525A0 (en) 1983-07-31
NO831743L (no) 1983-11-18
CA1196656A (en) 1985-11-12
NO164021C (no) 1990-08-22
IE830960L (en) 1983-11-17
AU1423083A (en) 1983-11-24
DK164661C (da) 1992-12-14
GR77487B (ko) 1984-09-24
JPS58208255A (ja) 1983-12-03
KR900006127B1 (ko) 1990-08-24
DK218083D0 (da) 1983-05-16
DE3360386D1 (de) 1985-08-14
IL68525A (en) 1986-07-31
NZ204017A (en) 1985-03-20
ZA833012B (en) 1984-01-25

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