FI108640B - Menetelmä puhtaan sitalopraamin valmistamiseksi - Google Patents

Menetelmä puhtaan sitalopraamin valmistamiseksi Download PDF

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Publication number
FI108640B
FI108640B FI20010501A FI20010501A FI108640B FI 108640 B FI108640 B FI 108640B FI 20010501 A FI20010501 A FI 20010501A FI 20010501 A FI20010501 A FI 20010501A FI 108640 B FI108640 B FI 108640B
Authority
FI
Finland
Prior art keywords
citalopram
cyanide
process according
reaction
distillation
Prior art date
Application number
FI20010501A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI20010501A0 (fi
Inventor
Andrea Castellin
Giulio Volpe
Federico Sbrogio
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of FI20010501A0 publication Critical patent/FI20010501A0/fi
Application granted granted Critical
Publication of FI108640B publication Critical patent/FI108640B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI20010501A 2000-12-28 2001-03-13 Menetelmä puhtaan sitalopraamin valmistamiseksi FI108640B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK200001943 2000-12-28
DKPA200001943 2000-12-28

Publications (2)

Publication Number Publication Date
FI20010501A0 FI20010501A0 (fi) 2001-03-13
FI108640B true FI108640B (fi) 2002-02-28

Family

ID=8159933

Family Applications (2)

Application Number Title Priority Date Filing Date
FI20010501A FI108640B (fi) 2000-12-28 2001-03-13 Menetelmä puhtaan sitalopraamin valmistamiseksi
FI20011578A FI20011578A0 (fi) 2000-12-28 2001-07-26 Menetelmä puhtaan sitalopraamin valmistamiseksi

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20011578A FI20011578A0 (fi) 2000-12-28 2001-07-26 Menetelmä puhtaan sitalopraamin valmistamiseksi

Country Status (41)

Country Link
US (2) US6855834B2 (es)
EP (1) EP1181272B1 (es)
JP (1) JP2003519121A (es)
KR (1) KR100430746B1 (es)
CN (1) CN1366526A (es)
AR (1) AR029898A1 (es)
AT (2) ATE222899T1 (es)
AU (3) AU3920201A (es)
BE (2) BE1013417A6 (es)
BG (1) BG106219A (es)
BR (1) BR0106271A (es)
CA (1) CA2359810C (es)
CH (1) CH691536A5 (es)
CZ (1) CZ293140B6 (es)
DE (1) DE60100016T2 (es)
DK (1) DK1181272T3 (es)
EA (1) EA003459B1 (es)
ES (2) ES2181663T3 (es)
FI (2) FI108640B (es)
FR (1) FR2818977B1 (es)
GB (2) GB2356199B (es)
GR (1) GR20010100131A (es)
HK (1) HK1049332A1 (es)
HR (1) HRP20020005A2 (es)
HU (2) HU0101028D0 (es)
IE (2) IES20010253A2 (es)
IL (1) IL147162A0 (es)
IS (1) IS5884A (es)
IT (1) ITMI20010604A1 (es)
MX (1) MXPA01013336A (es)
NL (1) NL1017534C1 (es)
NO (1) NO313047B1 (es)
NZ (1) NZ516299A (es)
PL (1) PL353369A1 (es)
PT (1) PT1181272E (es)
SE (1) SE0103044L (es)
SK (1) SK284418B6 (es)
TR (1) TR200200018T1 (es)
UA (1) UA71635C2 (es)
WO (1) WO2001047877A2 (es)
ZA (1) ZA200110133B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) * 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
TR200101874T1 (tr) 1999-10-25 2002-02-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem
EA002801B1 (ru) 1999-10-25 2002-10-31 Х.Лундбекк А/С Способ получения циталопрама
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
ATE261953T1 (de) 1999-12-28 2004-04-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
TR200201688T2 (tr) 1999-12-30 2002-11-21 H. Lundbeck A/S Sitalopram hazırlama yöntemi.
EA005134B1 (ru) 2000-01-14 2004-12-30 Х.Лундбекк А/С Способ получения 5-цианофталида
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
TR200202166T2 (tr) 2000-03-13 2002-12-23 H. Lndbeck A/S Sitalopramın preparasyon metodu
EA200200968A1 (ru) 2000-03-13 2003-02-27 Х.Лундбекк А/С Поэтапное алкилирование 5-замещенных 1-(4-фторфенил)-1,3-дигидроизобензофуранов
CA2402557A1 (en) 2000-03-14 2001-09-20 Hans Petersen Method for the preparation of citalopram
CA2402869A1 (en) * 2000-03-16 2001-09-20 Hans Petersen Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354880C (en) 2000-08-18 2003-06-03 H. Lundbeck A/S Method for the preparation of citalopram
KR100439329B1 (ko) 2000-12-22 2004-07-07 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
AU3920201A (en) 2000-12-28 2001-07-09 H. Lundbeck A/S Process for the preparation of pure citalopram
GB2376945A (en) * 2001-06-27 2002-12-31 Cipla Ltd Citalopram preparation
US7148364B2 (en) 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
ES2194597B2 (es) * 2002-01-25 2004-08-01 Esteve Quimica, S.A. Procedimiento para la obtencion de citalopram.
GB2386119A (en) * 2002-02-27 2003-09-10 Cipla Ltd Purification of citalopram
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
WO2004085416A1 (en) * 2003-03-24 2004-10-07 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US7019153B2 (en) 2003-06-10 2006-03-28 Sun Pharmaceutical Industries Limited Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US7834201B2 (en) 2005-06-22 2010-11-16 H. Lundbeck A/S Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI358407B (en) * 2005-06-22 2012-02-21 Lundbeck & Co As H Crystalline base of escitalopram and orodispersibl

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL135959C (es) 1964-12-23
GB1143702A (es) 1965-03-18
DE1619713A1 (de) * 1967-03-29 1970-12-17 Leybold Heraeus Gmbh & Co Kg Vorrichtung zur Vakuum- und Kurzwegdestillation
DE2135085C3 (de) 1971-07-14 1981-12-03 Basf Ag, 6700 Ludwigshafen Verfahren zur Wiedergewinnung von Caprolactam aus einem Gemisch, das Caprolactam und dessen Oligomere enthält
DE2442426C2 (de) 1974-09-05 1983-04-07 Bayer Ag, 5090 Leverkusen Diisocyanatodiketene, Verfahren zu deren Herstellung und deren Verwendung
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
IT8020902A0 (it) 1980-03-25 1980-03-25 Snia Viscosa Procedimento ed apparecchiatura per la separazione continua per via termica di miscele liquide dicomposti termolabili.
JPS6082101A (ja) 1983-10-13 1985-05-10 Mitsui Toatsu Chem Inc 高沸点重合性化合物の薄膜蒸留による精製方法
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
FR2656305B1 (fr) 1989-12-22 1992-04-10 Norsolor Sa Procede de purification du (meth)acrylate de glycidyle.
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
US5582692A (en) 1994-10-07 1996-12-10 Artisan Industries, Inc. Method for the purification of vitamin E
ATE252568T1 (de) 1996-05-21 2003-11-15 Exxonmobil Chem Patents Inc Reinigung von glycidylestern durch dünnschichtverdampfung
US6136991A (en) * 1996-05-21 2000-10-24 Exxon Chemical Patents Inc. Glycidyl ester adducts having increased glass transition temperatures
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
JP3526581B2 (ja) 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
DE19734673A1 (de) 1997-08-11 1999-02-18 Rwe Dea Ag Verfahren zur Herstellung von metallfreien Guerbetalkoholen
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
DE69714480T2 (de) 1997-11-11 2003-03-06 Lundbeck & Co As H Verfahren zur Herstellung von Citalopram
DE69920329T3 (de) 1998-06-19 2009-07-09 Shin-Etsu Chemical Co., Ltd. Destillationsverfahren für (Meth)acryloxysilane
WO2000023431A1 (en) * 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
CZ300408B6 (cs) 1998-12-23 2009-05-13 H. Lundbeck A/S Zpusob výroby 5-kyanoftalidu
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
PL198024B1 (pl) 1999-04-14 2008-05-30 Lundbeck & Co As H Sposób wytwarzania citalopramu, związki pośrednie i ich zastosowanie do wytwarzania citalopramu
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
TR200101874T1 (tr) 1999-10-25 2002-02-21 H. Lundbeck A/S Sitalopram hazırlanması için yöntem
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
KR100439329B1 (ko) 2000-12-22 2004-07-07 하. 룬트벡 아크티에 셀스카브 순수한 시탈로프람의 제조방법
AU3920201A (en) 2000-12-28 2001-07-09 H. Lundbeck A/S Process for the preparation of pure citalopram
US6781003B1 (en) * 2003-06-09 2004-08-24 Aurobindo Pharma Ltd. Preparation of pure citalopram

Also Published As

Publication number Publication date
FI20011578A0 (fi) 2001-07-26
HU0102818D0 (en) 2001-09-28
NZ516299A (en) 2002-12-20
IS5884A (is) 2002-06-28
NO20011272L (no) 2002-07-01
GB0117095D0 (en) 2001-09-05
AR029898A1 (es) 2003-07-23
NL1017534C1 (nl) 2001-04-26
EP1181272A2 (en) 2002-02-27
EA200200016A1 (ru) 2002-04-25
KR20020073379A (ko) 2002-09-26
AU2001100399A4 (en) 2001-11-01
KR100430746B1 (ko) 2004-05-10
WO2001047877A2 (en) 2001-07-05
ATE222899T1 (de) 2002-09-15
AT4368U1 (de) 2001-06-25
EA003459B1 (ru) 2003-06-26
MXPA01013336A (es) 2002-07-09
ES2170733B1 (es) 2003-12-16
ZA200110133B (en) 2003-01-13
DK1181272T3 (da) 2002-12-30
AU3920201A (en) 2001-07-09
DE60100016D1 (de) 2002-10-02
ES2170733A1 (es) 2002-08-01
GB2361697A (en) 2001-10-31
GB2356199B (en) 2001-10-03
FR2818977B1 (fr) 2003-12-05
GB0105981D0 (en) 2001-05-02
HRP20020005A2 (en) 2003-04-30
BR0106271A (pt) 2002-05-21
ITMI20010604A1 (it) 2002-09-22
PL353369A1 (en) 2003-11-17
SE0103044D0 (sv) 2001-09-14
CZ2001891A3 (cs) 2002-08-14
TR200200018T1 (tr) 2002-06-21
GR20010100131A (el) 2002-10-09
CZ293140B6 (cs) 2004-02-18
NO20011272D0 (no) 2001-03-13
UA71635C2 (uk) 2004-12-15
PT1181272E (pt) 2003-01-31
ITMI20010604A0 (it) 2001-03-22
FI20010501A0 (fi) 2001-03-13
GB2356199A (en) 2001-05-16
BG106219A (en) 2002-08-30
HUP0102818A2 (hu) 2001-12-28
IES20010253A2 (en) 2002-03-06
US20020087012A1 (en) 2002-07-04
IL147162A0 (en) 2002-08-14
CA2359810A1 (en) 2001-07-05
AU2001100399B4 (en) 2002-03-21
HK1049332A1 (zh) 2003-05-09
US20030178295A1 (en) 2003-09-25
IES20010632A2 (en) 2002-03-06
SE0103044L (sv) 2002-06-29
BE1013417A6 (fr) 2001-12-04
US6855834B2 (en) 2005-02-15
SK284418B6 (sk) 2005-04-01
ES2181663T3 (es) 2003-03-01
CN1366526A (zh) 2002-08-28
JP2003519121A (ja) 2003-06-17
FR2818977A1 (fr) 2002-07-05
BE1013316A6 (fr) 2001-11-06
NO313047B1 (no) 2002-08-05
EP1181272B1 (en) 2002-08-28
SK18472001A3 (sk) 2002-05-09
AU750006B1 (en) 2002-07-11
CA2359810C (en) 2002-11-05
CH691536A5 (de) 2001-08-15
HU0101028D0 (en) 2001-05-28
DE60100016T2 (de) 2003-04-17
WO2001047877A3 (en) 2001-12-27
HUP0102818A3 (en) 2003-07-28

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