EA200100894A1 - Новый способ получения алендроновой кислоты - Google Patents

Новый способ получения алендроновой кислоты

Info

Publication number
EA200100894A1
EA200100894A1 EA200100894A EA200100894A EA200100894A1 EA 200100894 A1 EA200100894 A1 EA 200100894A1 EA 200100894 A EA200100894 A EA 200100894A EA 200100894 A EA200100894 A EA 200100894A EA 200100894 A1 EA200100894 A1 EA 200100894A1
Authority
EA
Eurasian Patent Office
Prior art keywords
acid
alandronic
obtaining
new method
group
Prior art date
Application number
EA200100894A
Other languages
English (en)
Other versions
EA003861B1 (ru
Inventor
Рами Лидор-Хадас
Ревитал Лифшиц
Original Assignee
Тева Фармасьютикал Индастриес Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тева Фармасьютикал Индастриес Лтд. filed Critical Тева Фармасьютикал Индастриес Лтд.
Publication of EA200100894A1 publication Critical patent/EA200100894A1/ru
Publication of EA003861B1 publication Critical patent/EA003861B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Предложен способ получения алендроновой кислоты. Способ включает стадии взаимодействия соединения формулы I с НРОгде R - имидогруппа и Rвыбирают из группы, которая состоит из атома хлора, брома, йода или фтора, гидрокси-, амино-, -ORили -ОС(O)Rгруппы, где R- С-Салкил-, С-Сциклоалкил- или С-Сарилгруппа; и далее реакцию продукта первой стадии с агентом, снимающим защитную группу. Далее алендроновую кислоту выделяют. Способ безопасен, эффективен и пригоден при производстве в крупном масштабе.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100894A 1999-02-17 2000-02-11 Новый способ получения алендроновой кислоты EA003861B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25163499A 1999-02-17 1999-02-17
PCT/US2000/003586 WO2000049026A1 (en) 1999-02-17 2000-02-11 Novel process for preparing alendronic acid

Publications (2)

Publication Number Publication Date
EA200100894A1 true EA200100894A1 (ru) 2002-04-25
EA003861B1 EA003861B1 (ru) 2003-10-30

Family

ID=22952795

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100894A EA003861B1 (ru) 1999-02-17 2000-02-11 Новый способ получения алендроновой кислоты

Country Status (29)

Country Link
US (2) US6201148B1 (ru)
EP (1) EP1169326B1 (ru)
JP (1) JP3930251B2 (ru)
KR (1) KR100665633B1 (ru)
AT (1) ATE271057T1 (ru)
AU (1) AU770312B2 (ru)
BG (1) BG64851B1 (ru)
BR (1) BR0010112A (ru)
CA (1) CA2363317C (ru)
CZ (1) CZ296921B6 (ru)
DE (1) DE60012165T2 (ru)
DK (1) DK1169326T3 (ru)
EA (1) EA003861B1 (ru)
EE (1) EE04593B1 (ru)
ES (1) ES2222188T3 (ru)
HK (1) HK1041004B (ru)
HR (1) HRP20010606B1 (ru)
HU (1) HUP0200342A3 (ru)
IL (1) IL144941A0 (ru)
IS (1) IS6050A (ru)
MX (1) MXPA01008332A (ru)
NO (1) NO20013984L (ru)
NZ (1) NZ513551A (ru)
PL (1) PL350126A1 (ru)
PT (1) PT1169326E (ru)
SK (1) SK285163B6 (ru)
WO (1) WO2000049026A1 (ru)
YU (1) YU59401A (ru)
ZA (1) ZA200106816B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU770312B2 (en) * 1999-02-17 2004-02-19 Teva Pharmaceutical Industries Ltd. Novel process for preparing alendronic acid
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
BR0215413A (pt) 2001-12-24 2004-12-14 Teva Pharma Formula dosada com um comprimido central de ingrediente ativo encapado em uma capa anular prensada de material em pó ou granulado e processo e conjunto de ferramentas para a sua produção
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2007083240A2 (en) * 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US22A (en) * 1836-09-05 Spbcificatioh
US562A (en) * 1838-01-09 Scale beam and weight
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4621107A (en) * 1982-08-12 1986-11-04 Lagow Richard J Fluorinated elastomeric materials
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US5039819A (en) * 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
GB2248063A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Phthalimido alkanoyl phosphonates
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
AU770312B2 (en) * 1999-02-17 2004-02-19 Teva Pharmaceutical Industries Ltd. Novel process for preparing alendronic acid

Also Published As

Publication number Publication date
EE04593B1 (et) 2006-02-15
DK1169326T3 (da) 2004-10-04
SK11862001A3 (sk) 2002-02-05
AU3488600A (en) 2000-09-04
NO20013984D0 (no) 2001-08-16
AU770312B2 (en) 2004-02-19
KR20010102162A (ko) 2001-11-15
YU59401A (sh) 2004-05-12
NO20013984L (no) 2001-10-17
IL144941A0 (en) 2002-06-30
IS6050A (is) 2001-08-16
ZA200106816B (en) 2002-08-19
EP1169326A1 (en) 2002-01-09
HRP20010606B1 (en) 2005-08-31
CA2363317C (en) 2008-04-29
EP1169326B1 (en) 2004-07-14
CA2363317A1 (en) 2000-08-24
HUP0200342A2 (en) 2002-06-29
EE200100436A (et) 2002-12-16
HUP0200342A3 (en) 2005-02-28
DE60012165T2 (de) 2005-08-25
HK1041004B (zh) 2005-01-21
ES2222188T3 (es) 2005-02-01
BR0010112A (pt) 2001-12-26
NZ513551A (en) 2003-02-28
CZ20012942A3 (cs) 2002-01-16
ATE271057T1 (de) 2004-07-15
PL350126A1 (en) 2002-11-04
US6201148B1 (en) 2001-03-13
EA003861B1 (ru) 2003-10-30
JP2002537303A (ja) 2002-11-05
JP3930251B2 (ja) 2007-06-13
CZ296921B6 (cs) 2006-07-12
EP1169326A4 (en) 2002-05-22
HRP20010606A2 (en) 2002-10-31
MXPA01008332A (es) 2003-01-08
BG105825A (en) 2002-04-30
US20020052527A1 (en) 2002-05-02
DE60012165D1 (de) 2004-08-19
BG64851B1 (bg) 2006-06-30
HK1041004A1 (en) 2002-06-28
PT1169326E (pt) 2004-10-29
KR100665633B1 (ko) 2007-01-10
WO2000049026A1 (en) 2000-08-24
SK285163B6 (sk) 2006-07-07

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU