ITMI20020908A1 - Processo di preparazione di sodio alendronato - Google Patents

Processo di preparazione di sodio alendronato

Info

Publication number
ITMI20020908A1
ITMI20020908A1 IT2002MI000908A ITMI20020908A ITMI20020908A1 IT MI20020908 A1 ITMI20020908 A1 IT MI20020908A1 IT 2002MI000908 A IT2002MI000908 A IT 2002MI000908A IT MI20020908 A ITMI20020908 A IT MI20020908A IT MI20020908 A1 ITMI20020908 A1 IT MI20020908A1
Authority
IT
Italy
Prior art keywords
alendronate sodium
preparation process
sodium preparation
reaction
acid
Prior art date
Application number
IT2002MI000908A
Other languages
English (en)
Inventor
Ferra Lorenzo De
Pietro Massardo
Stefano Turchetta
Paolo Castellato
Original Assignee
Chemi Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemi Spa filed Critical Chemi Spa
Priority to IT2002MI000908A priority Critical patent/ITMI20020908A1/it
Publication of ITMI20020908A0 publication Critical patent/ITMI20020908A0/it
Priority to ES02807339T priority patent/ES2338540T3/es
Priority to PCT/IB2002/004941 priority patent/WO2003093282A1/en
Priority to KR1020047017332A priority patent/KR20050025162A/ko
Priority to AU2002367897A priority patent/AU2002367897A1/en
Priority to EP02807339A priority patent/EP1504012B9/en
Priority to AT02807339T priority patent/ATE452899T1/de
Priority to US10/512,930 priority patent/US7332603B2/en
Priority to JP2004501421A priority patent/JP2005523938A/ja
Priority to DE60234870T priority patent/DE60234870D1/de
Publication of ITMI20020908A1 publication Critical patent/ITMI20020908A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
IT2002MI000908A 2002-04-29 2002-04-29 Processo di preparazione di sodio alendronato ITMI20020908A1 (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IT2002MI000908A ITMI20020908A1 (it) 2002-04-29 2002-04-29 Processo di preparazione di sodio alendronato
DE60234870T DE60234870D1 (de) 2002-04-29 2002-11-25 Herstellung von bisphosphonsaüren und salzen davon
AU2002367897A AU2002367897A1 (en) 2002-04-29 2002-11-25 Preparation of biphosphonic acids and salts thereof
PCT/IB2002/004941 WO2003093282A1 (en) 2002-04-29 2002-11-25 Preparation of biphosphonic acids and salts thereof
KR1020047017332A KR20050025162A (ko) 2002-04-29 2002-11-25 비스포스폰산 및 이의 염의 제조 방법
ES02807339T ES2338540T3 (es) 2002-04-29 2002-11-25 Preparacion de acidos bisfosfonicos y sus sales.
EP02807339A EP1504012B9 (en) 2002-04-29 2002-11-25 Preparation of biphosphonic acids and salts thereof
AT02807339T ATE452899T1 (de) 2002-04-29 2002-11-25 Herstellung von bisphosphonsaüren und salzen davon
US10/512,930 US7332603B2 (en) 2002-04-29 2002-11-25 Preparation of biphosphonic acids and salts thereof
JP2004501421A JP2005523938A (ja) 2002-04-29 2002-11-25 ビスホスホン酸類およびそれらの塩類の製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2002MI000908A ITMI20020908A1 (it) 2002-04-29 2002-04-29 Processo di preparazione di sodio alendronato

Publications (2)

Publication Number Publication Date
ITMI20020908A0 ITMI20020908A0 (it) 2002-04-29
ITMI20020908A1 true ITMI20020908A1 (it) 2003-10-29

Family

ID=11449800

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2002MI000908A ITMI20020908A1 (it) 2002-04-29 2002-04-29 Processo di preparazione di sodio alendronato

Country Status (10)

Country Link
US (1) US7332603B2 (it)
EP (1) EP1504012B9 (it)
JP (1) JP2005523938A (it)
KR (1) KR20050025162A (it)
AT (1) ATE452899T1 (it)
AU (1) AU2002367897A1 (it)
DE (1) DE60234870D1 (it)
ES (1) ES2338540T3 (it)
IT (1) ITMI20020908A1 (it)
WO (1) WO2003093282A1 (it)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
NZ552514A (en) 2001-12-24 2008-08-29 Teva Pharma Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
DE60331724D1 (de) * 2002-05-17 2010-04-29 Teva Pharma Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
US20040230076A1 (en) * 2003-02-27 2004-11-18 Revital Lifshitz-Liron Process for purification of zoledronic acid
ATE425170T1 (de) * 2003-07-03 2009-03-15 Teva Pharma Kristallformen der zoledronsäure und deren natrioumsalze, amorphes natriumzoledronat und verfahren zu deren herstellung
WO2005063717A1 (en) * 2003-12-26 2005-07-14 Natco Pharma Limited An improved process for the preparation of zoledronic acid
EP1571152B1 (en) * 2004-03-03 2007-08-08 CHEMI S.p.A. Amorphous 3-Pyridil-1-Hydroxyethyliden-1,1-Biphosphonic acid monosodium salt and process for the preparation thereof .
CA2576659A1 (en) 2004-08-23 2006-03-02 Teva Pharmaceutical Industries Ltd. Solid and crystalline ibandronate sodium and processes for preparation thereof
PL199215B1 (pl) * 2004-12-28 2008-08-29 Politechnika Gdanska Sposób wytwarzania kwasu [1-hydroksy-2-(3-pirydylo)etylidenobisfosfonowego] oraz jego soli monosodowej dwu i pół wodnej
US8071574B2 (en) 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation
AR054673A1 (es) * 2005-07-28 2007-07-11 Gador Sa Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende
WO2007032808A1 (en) * 2005-09-12 2007-03-22 Dr. Reddy's Laboratories Ltd. Crystalline trihydrate of zoledronic acid
WO2007083240A2 (en) * 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
WO2007125521A2 (en) * 2006-05-02 2007-11-08 Ranbaxy Laboratories Limited Polymorphic form of zoledronic acid and processes for their preparation
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Ａｄｅｋａ スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
KR20090005206A (ko) 2006-05-11 2009-01-12 인드-스위프트 래버러토리즈 리미티드 순수한 리세드론산 또는 염의 제조 방법
EP1923394A1 (en) * 2006-11-16 2008-05-21 Sandoz A/S Reagent and use thereof for the production of bisphosphonates
WO2008152518A2 (en) * 2007-05-16 2008-12-18 Actavis Group Ptc Ehf Process for the preparation of risedronic acid or risedronate sodium
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
US8080323B2 (en) * 2007-06-28 2011-12-20 Kennametal Inc. Cutting insert with a wear-resistant coating scheme exhibiting wear indication and method of making the same
KR100877667B1 (ko) * 2007-06-28 2009-01-08 보령제약 주식회사 리세드로네이트의 제조 방법
JP5258370B2 (ja) * 2008-05-08 2013-08-07 ダイト株式会社 リセドロン酸の工業的製造方法
PL213599B1 (pl) * 2008-10-31 2013-03-29 Politechnika Gdanska Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
EP2192126B1 (en) 2008-11-26 2013-03-27 Synthon B.V. Process for making zoledronic acid
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
LT2459176T (lt) * 2009-07-31 2017-12-11 Grünenthal GmbH Kristalizacijos būdas ir bioprieinamumas
WO2011016738A1 (en) 2009-08-05 2011-02-10 Zaklady Farmaceutyczne Polpharma Sa A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate
US8882740B2 (en) * 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
WO2012071517A2 (en) 2010-11-24 2012-05-31 Thar Pharmaceuticals, Inc. Novel crystalline forms
WO2017208070A1 (en) 2016-05-31 2017-12-07 Grünenthal GmbH Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis
CN106632483B (zh) * 2016-12-20 2018-11-16 隋妍蕾 一种替诺福韦二吡呋酯的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3262971A (en) * 1962-10-12 1966-07-26 Monsanto Res Corp Phosphorus compounds
DE1250439B (de) * 1965-03-30 1967-09-21 The Procter & Gamble Company, Cincinnati, Ohio (V. St. A.) Verfahren zur Herstellung von Äthan - 1 - hydroxy - 1,1-diphosphonsäure
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2943498C2 (de) * 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
SU1719405A1 (ru) * 1985-07-02 1992-03-15 Институт Химической Кинетики И Горения Со Ан Ссср Способ получени высших 1-оксиалкилиден-1,1-дифосфоновых кислот или их смесей, или солей
DE3700772A1 (de) * 1987-01-13 1988-07-21 Inst Khim Kinetiki I Gorenija Verfahren zur herstellung von i-funktionellsubstituierten alkyliden-i,i-diphosphonsaeuren und deren gemischen
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
KR100192215B1 (ko) * 1996-09-03 1999-06-15 강재헌 3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법
CA2197267C (en) 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
NZ513551A (en) 1999-02-17 2003-02-28 Teva Pharma Novel process for preparing alendronic acid
ES2153794B1 (es) 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PE20011065A1 (es) * 2000-02-01 2001-11-21 Procter & Gamble Proceso para fabricar bisfosfonatos geminales
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems

Also Published As

Publication number Publication date
KR20050025162A (ko) 2005-03-11
EP1504012A1 (en) 2005-02-09
JP2005523938A (ja) 2005-08-11
ATE452899T1 (de) 2010-01-15
WO2003093282A8 (en) 2007-09-07
AU2002367897A1 (en) 2003-11-17
ES2338540T3 (es) 2010-05-10
DE60234870D1 (de) 2010-02-04
AU2002367897A8 (en) 2003-11-17
ITMI20020908A0 (it) 2002-04-29
EP1504012B9 (en) 2010-04-28
WO2003093282A1 (en) 2003-11-13
EP1504012B1 (en) 2009-12-23
US7332603B2 (en) 2008-02-19
US20050288509A1 (en) 2005-12-29

Similar Documents

Publication Publication Date Title
ITMI20020908A1 (it) Processo di preparazione di sodio alendronato
DE60312261D1 (de) Lösung zur stromlosen Nickel-Plattierung
DE60102899D1 (de) Verfahren zur lösung von glucagon-ähnlichen peptid-1 (glp-1) verbindungen
ZA200710628B (en) Process for preparing low-by-product methylglycine-N, N-diacetic acid tri (alkali metal) salts
ATE235928T1 (de) Beschichtungsverfahren von medizinischen implantaten
BR0112538A (pt) Sais estáveis de ácido o-acetilsalicìlico com aminoácidos básicos
BR0307236A (pt) Processo para fabricação de compostos orgânicos
GB2446992A (en) Pathogen-controlling products
DK0797426T3 (da) Dannelse af stabile, vandige opløsninger af tinforbindelser
DE50204382D1 (de) Verfahren zur Gewinnung von Rhenium
FI20000515A0 (fi) Menetelmä bioaktiivisen lasin pinnan karhentamiseksi
BR0115755A (pt) Processo para preparação de ácido 1-(aminometil) ciclohexano-acético
BR9807154A (pt) Processo para a produção de um composto de 2,3-di-hidroxipropilaamino, e , composto.
TR200002384T2 (tr) Sulu, metal iyonsuz hidroksilamin çözeltileri üretim yöntemi
BR9401441A (pt) Processo de fabricação de uma membrana bipolar
DE602005011797D1 (de) Aufreinigung von n-(phosphonomethyl)glycin
PT1803727E (pt) Processo melhorado para o fabrico de ácido 4-amino-hidroxibutilideno-1,1 bisfosfónico e seus sais
ES2083576T3 (es) Procedimiento para la obtencion de una solucion de triformiato de aluminio que contiene metales alcalinos y/o alcalinoterreos, soluciones altamente concentradas de triformiato de aluminio que contienen metales alcalinos y/o alcalinoterreos y su empleo.
MXPA02010014A (es) Metodo para producir un recubrimiento no lixiviante durablemente hidrofilico para sustancias hidrofobicas.
PT1109782E (pt) Processo para a producao de acidos azetidino-2-carboxilicos (azeoh) protegidos em n
HUP0500184A2 (hu) Eljárás D-glükuronsav előállítására
EP1449821A4 (en) OPTICALLY ACTIVE MANDELIC ACID AND ITS DERIVATIVE, AND CORRESPONDING CRYSTALLIZATION PROCESS
BR0016170A (pt) Processo para preparação de tienopirimidinas
DK1431419T3 (da) Alkalimetalhydroxidinddampersystem
UA40765A (uk) Прямий замаслювач для обробки скляного волокна