DE60331724D1 - Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren - Google Patents

Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren

Info

Publication number
DE60331724D1
DE60331724D1 DE60331724T DE60331724T DE60331724D1 DE 60331724 D1 DE60331724 D1 DE 60331724D1 DE 60331724 T DE60331724 T DE 60331724T DE 60331724 T DE60331724 T DE 60331724T DE 60331724 D1 DE60331724 D1 DE 60331724D1
Authority
DE
Germany
Prior art keywords
preparation
bisphosphonic acids
certain solvents
acid
diluent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60331724T
Other languages
English (en)
Inventor
Rami Lidor-Hadas
Zvi Harel
Revital Lifshitz-Liron
Eti Kovalevski-Liron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Application granted granted Critical
Publication of DE60331724D1 publication Critical patent/DE60331724D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
DE60331724T 2002-05-17 2003-05-19 Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren Expired - Fee Related DE60331724D1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US38128402P 2002-05-17 2002-05-17
US40131302P 2002-08-06 2002-08-06
US42333702P 2002-11-01 2002-11-01
US43183802P 2002-12-09 2002-12-09
US45019303P 2003-02-25 2003-02-25
PCT/US2003/015676 WO2003097655A1 (en) 2002-05-17 2003-05-19 Use of certain diluents for making bisphosphonic acids

Publications (1)

Publication Number Publication Date
DE60331724D1 true DE60331724D1 (de) 2010-04-29

Family

ID=29554537

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60331724T Expired - Fee Related DE60331724D1 (de) 2002-05-17 2003-05-19 Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren

Country Status (12)

Country Link
US (3) US7038083B2 (de)
EP (1) EP1476451B1 (de)
JP (1) JP3857706B2 (de)
KR (1) KR100681282B1 (de)
CN (1) CN1665825A (de)
AT (1) ATE461205T1 (de)
AU (1) AU2003233569A1 (de)
CA (2) CA2485443C (de)
DE (1) DE60331724D1 (de)
IL (1) IL165227A0 (de)
PL (1) PL373574A1 (de)
WO (1) WO2003097655A1 (de)

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WO2007109585A2 (en) 2006-03-17 2007-09-27 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
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US7605148B2 (en) * 2007-04-16 2009-10-20 Aurobindo Pharma Ltd. Aqueous oral solution of bisphosphonic acid
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WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
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JP5258370B2 (ja) * 2008-05-08 2013-08-07 ダイト株式会社 リセドロン酸の工業的製造方法
CN102124016A (zh) * 2008-07-11 2011-07-13 斯索恩有限公司 制备1-羟基亚烷基-1，1-双膦酸的方法
PL213599B1 (pl) * 2008-10-31 2013-03-29 Politechnika Gdanska Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego
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Also Published As

Publication number Publication date
WO2003097655A1 (en) 2003-11-27
CA2657002A1 (en) 2003-11-27
US20060128960A1 (en) 2006-06-15
KR100681282B1 (ko) 2007-02-12
AU2003233569A1 (en) 2003-12-02
EP1476451A1 (de) 2004-11-17
CA2485443A1 (en) 2003-11-27
PL373574A1 (en) 2005-09-05
EP1476451B1 (de) 2010-03-17
CA2485443C (en) 2010-04-06
IL165227A0 (en) 2005-12-18
US20040043967A1 (en) 2004-03-04
KR20040111633A (ko) 2004-12-31
JP3857706B2 (ja) 2006-12-13
US20090209763A1 (en) 2009-08-20
CN1665825A (zh) 2005-09-07
US7038083B2 (en) 2006-05-02
ATE461205T1 (de) 2010-04-15
JP2005526140A (ja) 2005-09-02

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