YU59401A - Postupak za proizvodnju alendronske kiseline - Google Patents

Postupak za proizvodnju alendronske kiseline

Info

Publication number
YU59401A
YU59401A YU59401A YUP59401A YU59401A YU 59401 A YU59401 A YU 59401A YU 59401 A YU59401 A YU 59401A YU P59401 A YUP59401 A YU P59401A YU 59401 A YU59401 A YU 59401A
Authority
YU
Yugoslavia
Prior art keywords
alendronic acid
reacting
preparing
group
preparing alendronic
Prior art date
Application number
YU59401A
Other languages
English (en)
Inventor
Ramy Lidor-Hadas
Revital Lifshitz
Original Assignee
Teva Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.
Publication of YU59401A publication Critical patent/YU59401A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

Otkriven je novi postupak za dobijanje alendronske kiseline. Metod sadrži korake reagovanja jedinjenja formule (I) sa H3PO3 gde je R imido grupa i R1 je selekcionisano iz grupe koja se sastoji od hloro, bromo, jodo, fluoro, hidroksi, amino. -OR2 ili -OC(O)R2, gde je R2 C1-C12 alkil, C1-C12 cikloalkil, ili C1-C12 aril; i zatim reagovanja produkta iz prvog koraka sa agensom deprotekcije. Zatim se obnavlja alendronska kiselina. Metod je siguran, efiksan i pogodan za upotrebu na veliko.
YU59401A 1999-02-17 2000-02-11 Postupak za proizvodnju alendronske kiseline YU59401A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25163499A 1999-02-17 1999-02-17

Publications (1)

Publication Number Publication Date
YU59401A true YU59401A (sh) 2004-05-12

Family

ID=22952795

Family Applications (1)

Application Number Title Priority Date Filing Date
YU59401A YU59401A (sh) 1999-02-17 2000-02-11 Postupak za proizvodnju alendronske kiseline

Country Status (29)

Country Link
US (2) US6201148B1 (sh)
EP (1) EP1169326B1 (sh)
JP (1) JP3930251B2 (sh)
KR (1) KR100665633B1 (sh)
AT (1) ATE271057T1 (sh)
AU (1) AU770312B2 (sh)
BG (1) BG64851B1 (sh)
BR (1) BR0010112A (sh)
CA (1) CA2363317C (sh)
CZ (1) CZ296921B6 (sh)
DE (1) DE60012165T2 (sh)
DK (1) DK1169326T3 (sh)
EA (1) EA003861B1 (sh)
EE (1) EE04593B1 (sh)
ES (1) ES2222188T3 (sh)
HK (1) HK1041004B (sh)
HR (1) HRP20010606B1 (sh)
HU (1) HUP0200342A3 (sh)
IL (1) IL144941A0 (sh)
IS (1) IS6050A (sh)
MX (1) MXPA01008332A (sh)
NO (1) NO20013984L (sh)
NZ (1) NZ513551A (sh)
PL (1) PL350126A1 (sh)
PT (1) PT1169326E (sh)
SK (1) SK285163B6 (sh)
WO (1) WO2000049026A1 (sh)
YU (1) YU59401A (sh)
ZA (1) ZA200106816B (sh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3930251B2 (ja) * 1999-02-17 2007-06-13 テバ ファーマシューティカル インダストリーズ リミティド アレンドロン酸を製造するための新規な方法
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
CA2470495A1 (en) 2001-12-24 2003-07-17 Teva Pharmaceutical Industries Ltd. Dosage form with a core tablet of active ingredient sheathed in a compressed annular body of powder or granular material, and process and tooling for producing it
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2007083240A2 (en) * 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US562A (en) * 1838-01-09 Scale beam and weight
US22A (en) * 1836-09-05 Spbcificatioh
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4621107A (en) * 1982-08-12 1986-11-04 Lagow Richard J Fluorinated elastomeric materials
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
GB2248063A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Phthalimido alkanoyl phosphonates
US5039819A (en) * 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
JP3930251B2 (ja) * 1999-02-17 2007-06-13 テバ ファーマシューティカル インダストリーズ リミティド アレンドロン酸を製造するための新規な方法

Also Published As

Publication number Publication date
ZA200106816B (en) 2002-08-19
BG105825A (en) 2002-04-30
US20020052527A1 (en) 2002-05-02
AU770312B2 (en) 2004-02-19
CZ20012942A3 (cs) 2002-01-16
AU3488600A (en) 2000-09-04
JP3930251B2 (ja) 2007-06-13
HUP0200342A3 (en) 2005-02-28
KR100665633B1 (ko) 2007-01-10
ATE271057T1 (de) 2004-07-15
IS6050A (is) 2001-08-16
EP1169326A4 (en) 2002-05-22
EP1169326A1 (en) 2002-01-09
KR20010102162A (ko) 2001-11-15
EP1169326B1 (en) 2004-07-14
HK1041004A1 (en) 2002-06-28
DE60012165T2 (de) 2005-08-25
BG64851B1 (bg) 2006-06-30
WO2000049026A1 (en) 2000-08-24
DE60012165D1 (de) 2004-08-19
EE200100436A (et) 2002-12-16
ES2222188T3 (es) 2005-02-01
US6201148B1 (en) 2001-03-13
IL144941A0 (en) 2002-06-30
CA2363317C (en) 2008-04-29
EA003861B1 (ru) 2003-10-30
EE04593B1 (et) 2006-02-15
HRP20010606B1 (en) 2005-08-31
HUP0200342A2 (en) 2002-06-29
BR0010112A (pt) 2001-12-26
HRP20010606A2 (en) 2002-10-31
NO20013984D0 (no) 2001-08-16
MXPA01008332A (es) 2003-01-08
NZ513551A (en) 2003-02-28
PL350126A1 (en) 2002-11-04
HK1041004B (zh) 2005-01-21
DK1169326T3 (da) 2004-10-04
CZ296921B6 (cs) 2006-07-12
SK285163B6 (sk) 2006-07-07
CA2363317A1 (en) 2000-08-24
NO20013984L (no) 2001-10-17
SK11862001A3 (sk) 2002-02-05
EA200100894A1 (ru) 2002-04-25
PT1169326E (pt) 2004-10-29
JP2002537303A (ja) 2002-11-05

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