ES2170732B2 - Procedimiento para preparar citalopram purificado - Google Patents

Procedimiento para preparar citalopram purificado

Info

Publication number
ES2170732B2
ES2170732B2 ES200101762A ES200101762A ES2170732B2 ES 2170732 B2 ES2170732 B2 ES 2170732B2 ES 200101762 A ES200101762 A ES 200101762A ES 200101762 A ES200101762 A ES 200101762A ES 2170732 B2 ES2170732 B2 ES 2170732B2
Authority
ES
Spain
Prior art keywords
citalopram
crude
group
optionally
desmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200101762A
Other languages
English (en)
Other versions
ES2170732A1 (es
Inventor
Marco Villa
Federico Sbrogio
Robert Dancer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of ES2170732A1 publication Critical patent/ES2170732A1/es
Application granted granted Critical
Publication of ES2170732B2 publication Critical patent/ES2170732B2/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Abstract

Procedimiento para la preparación de citalopram purificado de fórmula I por separación de desmetil-citalopram con la fórmula III que comprende someter, opcionalmente, un producto de citalopram crudo que contiene la impureza de desmetil-citalopram a alguna purificación inicial y subsiguientemente tratar el producto crudo con un agente de formación de grupo amida o similar a amida elegido entre los agentes de fórmulas (a), b) o (c) en donde X es halógeno o un grupo O-CO-R'', Hal es halógeno, Y es O ó S, W es O, N ó S y R, R'', R''` y R''`'' se eligen cada uno de ellos entre el grupo formado por hidrógeno, alquilo y arilo o aralquilo sustituido opcionalmente; la mezcla de reacción se somete después a un lavado con ácido/base y/o cristalización y recristalización de citalopram con el fin de eliminar las amidas formadas a partir de la mezcla de citalopram crudo, y el producto de citalopram resultante se purifica opcionalmente de forma adicional y después se elabora y aísla como base o como una sal del mismo aceptable farmacéuticamente.
ES200101762A 2000-12-22 2001-07-27 Procedimiento para preparar citalopram purificado Expired - Fee Related ES2170732B2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200001929 2000-12-22

Publications (2)

Publication Number Publication Date
ES2170732A1 ES2170732A1 (es) 2002-08-01
ES2170732B2 true ES2170732B2 (es) 2003-09-16

Family

ID=8159922

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01913726T Expired - Lifetime ES2228824T3 (es) 2000-12-22 2001-03-07 Metodo de preparacion de citalopram puro.
ES200101762A Expired - Fee Related ES2170732B2 (es) 2000-12-22 2001-07-27 Procedimiento para preparar citalopram purificado

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES01913726T Expired - Lifetime ES2228824T3 (es) 2000-12-22 2001-03-07 Metodo de preparacion de citalopram puro.

Country Status (43)

Country Link
US (1) US6455710B1 (es)
EP (2) EP1181713B1 (es)
JP (1) JP3798982B2 (es)
KR (1) KR100439329B1 (es)
CN (1) CN1282648C (es)
AR (1) AR030056A1 (es)
AT (2) ATE277920T1 (es)
AU (2) AU3920101A (es)
BE (2) BE1013212A6 (es)
BG (1) BG65131B1 (es)
BR (1) BR0106272A (es)
CA (1) CA2360303C (es)
CH (1) CH691535A5 (es)
CZ (1) CZ292200B6 (es)
DE (2) DE60105926T2 (es)
DK (1) DK1181713T3 (es)
EA (1) EA003581B1 (es)
ES (2) ES2228824T3 (es)
FI (2) FI108639B (es)
FR (1) FR2812877B1 (es)
GB (1) GB2357763B (es)
GR (1) GR1003874B (es)
HK (1) HK1048812B (es)
HR (1) HRP20020004A2 (es)
HU (2) HU0101029D0 (es)
IE (1) IES20010254A2 (es)
IL (1) IL147226A (es)
IS (1) IS2060B (es)
IT (1) ITMI20010602A1 (es)
MX (1) MXPA01013151A (es)
NL (2) NL1017525C1 (es)
NO (1) NO20011271A (es)
NZ (1) NZ516298A (es)
PL (1) PL205724B1 (es)
PT (1) PT1181713E (es)
SE (1) SE517623C2 (es)
SG (1) SG167655A1 (es)
SI (1) SI1181713T1 (es)
SK (2) SK284428B6 (es)
TR (1) TR200201166T1 (es)
UA (1) UA71634C2 (es)
WO (1) WO2001045483A2 (es)
ZA (1) ZA200110179B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) * 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
AU778751B2 (en) 1999-12-28 2004-12-16 H. Lundbeck A/S Method for the preparation of citalopram
ATE253568T1 (de) 1999-12-30 2003-11-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
WO2001051477A1 (en) 2000-01-14 2001-07-19 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PL360110A1 (en) 2000-03-13 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
JP2003527385A (ja) 2000-03-13 2003-09-16 ハー・ルンドベック・アクチエゼルスカベット ５−置換された１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフランの段階的アルキル化法
PL360107A1 (en) 2000-03-14 2004-09-06 H.Lundbeck A/S Method for the preparation of citalopram
CZ20023406A3 (cs) * 2000-03-16 2003-01-15 H. Lundbeck A/S Způsob výroby 5-kyano-1-(4-fluorfenyl)-1,3-dihydroisobenzofuranu
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
EP1181272B1 (en) 2000-12-28 2002-08-28 H. Lundbeck A/S Process for the preparation of pure citalopram
GB0105627D0 (en) * 2001-03-07 2001-04-25 Cipla Ltd Preparation of phthalanes
PL372133A1 (en) * 2001-03-09 2005-07-11 Ranbaxy Laboratories Limited Process for the preparation of citalopram
US6967259B2 (en) * 2001-09-24 2005-11-22 Pharmachem Technologies Limited Process for the preparation of Citalopram intermediate
NZ532478A (en) * 2001-11-08 2007-02-23 Sepracor Inc Methods for treating depression and other CNS disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram
WO2003057132A2 (en) * 2002-01-07 2003-07-17 Sun Pharmaceutical Industries Limited Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB0204607D0 (en) * 2002-02-27 2002-04-10 Matrix Lab Ltd Process
CN1330628C (zh) * 2002-11-15 2007-08-08 阿克佐诺贝尔股份有限公司 脂肪腈的提纯/脱色处理
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
EP1486492A3 (en) * 2003-06-10 2005-02-23 Sun Pharmaceuticals Industries Ltd. A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran.
AU2003278409A1 (en) * 2003-10-28 2005-05-19 Krishnaji Upadhye Bhargav Improved process for the manufacture of citalopram hydrobromide
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
TWI347942B (en) * 2005-06-22 2011-09-01 Lundbeck & Co As H Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
CN114763343A (zh) * 2021-01-14 2022-07-19 浙江华海药业股份有限公司 一种西酞普兰或s-西酞普兰的纯化方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE536169C (de) * 1926-08-21 1931-10-20 British Dyestuffs Corp Ltd Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen
US1992111A (en) * 1931-06-20 1935-02-19 Du Pont Separation of secondary and tertiary amines
DE1032261B (de) * 1955-03-08 1958-06-19 Leda Chemicals Ltd Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung
GB1143702A (es) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
US4302399A (en) * 1978-09-28 1981-11-24 Dynapol Acetylation of crude reaction products containing polymeric colorants
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
US4943591A (en) 1984-10-17 1990-07-24 Glaxo Group Limited Dichloroaniline derivatives
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) * 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
EP0993524B1 (en) * 1997-06-30 2002-11-20 Beloit Technologies, Inc. Method and apparatus for the high speed application of coating to a traveling paper web
DK1015416T3 (da) * 1997-07-08 2001-11-05 Lundbeck & Co As H Fremgangsmåde til fremstilling af citalopram
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
JP3813820B2 (ja) * 1997-11-11 2006-08-23 ハー・ルンドベック・アクチエゼルスカベット シタロプラムの製造方法
EA002977B1 (ru) * 1998-10-20 2002-12-26 Х.Лундбекк А/С Способ получения циталопрама
PT1140886E (pt) 1998-12-23 2003-08-29 Lundbeck & Co As H Metodo para a preparacao de 5- cianoftalida
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
ES2195554T5 (es) 1999-04-14 2010-02-02 H. Lundbeck A/S Metodo para la preparacion de citalopram.
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991486A1 (it) * 1999-07-06 2001-01-06 Vis Farmaceutici S P A Processo per la sintesi di citalopram
ES2169709A1 (es) 1999-10-25 2002-07-01 Lundbeck & Co As H Metodo para la preparacion de citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IL144817A0 (en) 2000-08-18 2002-06-30 Lundbeck & Co As H Method for the preparation of citalopram
EP1181272B1 (en) 2000-12-28 2002-08-28 H. Lundbeck A/S Process for the preparation of pure citalopram

Also Published As

Publication number Publication date
HK1048812A1 (en) 2003-04-17
SE0103045D0 (sv) 2001-09-14
BE1013212A6 (fr) 2001-10-02
GB2357763A (en) 2001-07-04
IL147226A0 (en) 2002-08-14
EA200200018A1 (ru) 2002-04-25
HUP0102817A3 (en) 2003-07-28
FR2812877A1 (fr) 2002-02-15
BG65131B1 (bg) 2007-03-30
BG106203A (en) 2002-08-30
EA003581B1 (ru) 2003-06-26
WO2001045483A3 (en) 2001-12-27
FR2812877B1 (fr) 2003-04-04
PL353398A1 (en) 2003-11-17
CH691535A5 (de) 2001-08-15
JP2003517484A (ja) 2003-05-27
GR1003874B (el) 2002-04-24
HU0101029D0 (en) 2001-05-28
SK18482001A3 (sk) 2002-05-09
US20020120005A1 (en) 2002-08-29
HU0102817D0 (en) 2001-09-28
AU3920101A (en) 2001-07-03
EP1181713A2 (en) 2002-02-27
TR200201166T1 (tr) 2002-10-21
SE0103045L (sv) 2002-06-23
GB2357763B (en) 2002-01-16
HUP0102817A2 (hu) 2001-12-28
US6455710B1 (en) 2002-09-24
BE1013213A6 (fr) 2001-10-02
NO312462B1 (no) 2002-05-13
NZ516298A (en) 2002-12-20
BR0106272A (pt) 2004-06-15
FI20011577A0 (fi) 2001-07-26
DE60105926T2 (de) 2005-11-24
AR030056A1 (es) 2003-08-13
EP1462447A2 (en) 2004-09-29
CN1282648C (zh) 2006-11-01
SE517623C2 (sv) 2002-06-25
ITMI20010602A0 (it) 2001-03-22
NO20011271A (no) 2002-05-13
MXPA01013151A (es) 2002-08-12
KR100439329B1 (ko) 2004-07-07
IES20010254A2 (en) 2002-03-06
HRP20020004A2 (en) 2003-04-30
IS5883A (is) 2001-06-20
JP3798982B2 (ja) 2006-07-19
GB0105983D0 (en) 2001-05-02
FI108639B (fi) 2002-02-28
SK286283B6 (sk) 2008-06-06
NL1017525C1 (nl) 2001-04-26
NL1018360C1 (nl) 2001-10-04
UA71634C2 (uk) 2004-12-15
EP1462447A3 (en) 2004-11-17
AU2001100405A4 (en) 2001-11-01
CZ2001890A3 (cs) 2002-08-14
SG167655A1 (en) 2011-01-28
ES2170732A1 (es) 2002-08-01
IL147226A (en) 2006-04-10
AU2001100405B4 (en) 2002-03-21
CA2360303A1 (en) 2001-06-28
DE10112829C1 (de) 2002-07-25
PL205724B1 (pl) 2010-05-31
CN1366525A (zh) 2002-08-28
PT1181713E (pt) 2005-02-28
ATE277920T1 (de) 2004-10-15
FI20010500A0 (fi) 2001-03-13
ITMI20010602A1 (it) 2002-09-22
HK1048812B (zh) 2007-06-01
ZA200110179B (en) 2002-12-11
IS2060B (is) 2005-11-15
CZ292200B6 (cs) 2003-08-13
EP1181713B1 (en) 2004-09-29
CA2360303C (en) 2003-08-12
DK1181713T3 (da) 2005-01-31
SI1181713T1 (en) 2005-02-28
WO2001045483A2 (en) 2001-06-28
KR20020065345A (ko) 2002-08-13
SK284428B6 (sk) 2005-04-01
NO20011271D0 (no) 2001-03-13
AT4367U1 (de) 2001-06-25
DE60105926D1 (de) 2004-11-04
ES2228824T3 (es) 2005-04-16

Similar Documents

Publication Publication Date Title
ES2170732B2 (es) Procedimiento para preparar citalopram purificado
KR960037682A (ko) 축합 6환 화합물 및 그의 제조방법
AR029898A1 (es) Un metodo para la preparacion de un producto citalopram purificado
ES2158778B1 (es) Compuestos de sales de paroxetina, su preparacion y uso, y composiciones farmaceuticas que los contienen.
AR040253A1 (es) Fluorobenzamidas, procesos de preparacion y medicamento
JPH09508416A (ja) Ｈｉｖプロテアーゼ阻害剤および中間体
PT98375A (pt) Processo de preparacao de compostos de piperidina e de composicoes farmaceuticas
HUP0303106A2 (hu) Eljárás pravasztatin tisztítására
AR026222A1 (es) Compuestos derivados de acido antranilico
AR038342A1 (es) Derivados piridin-amido
AR015767A1 (es) Un proceso para la preparacion de compuestos de 3-glioxamida-1h-indol-4-sustituidos o sales farmaceuticamente aceptables o derivados prodrogas y loscompuestos obtenidos por dicho proceso.
DE602004015310D1 (de) Verfahren zur herstellung von mycophenolatmofetil
DE50306068D1 (de) Verfahren zum herstellen von salzen des tolperison
US2473484A (en) Method for the preparation of aminophthalidylalkanes
JP3078295B2 (ja) 芳香族アミノ酸誘導体及びその製造方法
ID20049A (id) Proses pemurnian
NO20045124L (no) Nye piperidinylalkylaminpyridazinonderivater, en fremgangsmate for fremstilling derav og farmasoytiske preparater inneholdende nevnte forbindelser
DK200100402A (da) Proces til fjernelse af desmethyl citalopram fra et citalopram produkt
CH385858A (fr) Procédé de préparation de nouveaux iminodibenzyles
TH51675B (th) แอนะลอกของ (1r,ซิส)-4-(6-อะมิโน-9h-ฟิวริน-9-อิล)-2-ไซโคลเพนทีน-1-เมทานอล ในฐานะสารต้านไวรัส
GB899014A (en) New derivatives of phenoxazine and processes for their production
DOP2001000175A (es) 5-cloro-3-(4-metasulfonilfenilo)-6´-metil-[2,3´] bipiridinilo en forma cristalina pura y proceso para la síntesis

Legal Events

Date Code Title Description
EC2A Search report published

Date of ref document: 20020801

Kind code of ref document: A1

Effective date: 20020801

FG2A Definitive protection

Ref document number: 2170732B2

Country of ref document: ES

FD2A Announcement of lapse in spain

Effective date: 20180807