GR1003874B - Μεθοδος για την παρασκευη καθαρης σιταλοπραμης - Google Patents
Μεθοδος για την παρασκευη καθαρης σιταλοπραμηςInfo
- Publication number
- GR1003874B GR1003874B GR20010100132A GR20010100132A GR1003874B GR 1003874 B GR1003874 B GR 1003874B GR 20010100132 A GR20010100132 A GR 20010100132A GR 20010100132 A GR20010100132 A GR 20010100132A GR 1003874 B GR1003874 B GR 1003874B
- Authority
- GR
- Greece
- Prior art keywords
- citalopram
- subjected
- preparation
- amide
- purification
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
παρούσα εφεύρεση αναφέρεται σε μια μέθοδο για την παρασκευή και τον καθαρισμό σιταλοπράμης Χημ. Τύπος (1) στην οποία μια ένωση τύπου (ΙΙ) στον οποίο το Ζ είναι ιώδιο , βρώμιο,χλώριο ή CF3-(CF2)n-SO2-O-, όπου το n είναι 0,1,2,3,4,5,6,7, ή 8, υποβάλλεται σε αντίδραση ανταλλαγής κυανίου με μια πηγή κυανίου το προκύπτον μικτό προιόν σιταλοπράμης υποβάλλεται προαιρετικά σε κάποιον αρχικό καθαρισμό και εν συνεχεία σε επεξεργασία με έναν παράγοντα σχηματισμού ομάδος αμιδίου ή παρόμοιου εν συνεχεία το αντιδρών μίγμα υποβάλλεται σε πλύση με οξύ/βάση και/ή κρυστάλλωση και ανακρυστάλλωση της σιταλοπράμης ώστε να απομακτυνθούν τα σχηματιζόμενα αμίδια απο τη μικτή σιταλοπράμη και η προκύπτουσα σιταλοπράμη προαιρετικά καθαρίζεται περαιτέρω, υποβάλλεται σε επεξεργασία και/ή απομονώνεται ως βάση ή ως φαρμακευτικά αποδεκτό άλας της .
ΰ
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200001929 | 2000-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
GR1003874B true GR1003874B (el) | 2002-04-24 |
Family
ID=8159922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR20010100132A GR1003874B (el) | 2000-12-22 | 2001-03-16 | Μεθοδος για την παρασκευη καθαρης σιταλοπραμης |
Country Status (43)
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
TR200102957T2 (tr) | 1999-04-14 | 2004-12-21 | H. Lundbeck A/S | Sitalopram hazırlanması için metod. |
ITMI991581A1 (it) * | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
ES2169709A1 (es) | 1999-10-25 | 2002-07-01 | Lundbeck & Co As H | Metodo para la preparacion de citalopram |
SI1246812T1 (en) | 1999-12-28 | 2004-08-31 | H. Lundbeck A/S | Method for the preparation of citalopram |
PT1246813E (pt) | 1999-12-30 | 2004-02-27 | Lundbeck & Co As H | Metodo para a preparacao de citalopram |
EA005134B1 (ru) | 2000-01-14 | 2004-12-30 | Х.Лундбекк А/С | Способ получения 5-цианофталида |
IES20010157A2 (en) | 2000-03-03 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
NZ521201A (en) | 2000-03-13 | 2004-02-27 | H | Method for the preparation of citalopram |
CN1427835A (zh) * | 2000-03-13 | 2003-07-02 | H·隆德贝克有限公司 | 5-取代的1-(4-氟苯基)-1,3-二氢异苯并呋喃的分步烷基化 |
IES20010206A2 (en) | 2000-03-13 | 2002-03-06 | Lundbeck & Co As H | Method for the preparation of citalopram |
ATE257832T1 (de) | 2000-03-14 | 2004-01-15 | Lundbeck & Co As H | Verfahren zur herstellung von citalopram |
WO2001068632A1 (en) * | 2000-03-16 | 2001-09-20 | H. Lundbeck A/S | Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
AR032455A1 (es) | 2000-05-12 | 2003-11-12 | Lundbeck & Co As H | Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva |
IL144817A0 (en) | 2000-08-18 | 2002-06-30 | Lundbeck & Co As H | Method for the preparation of citalopram |
PT1181272E (pt) | 2000-12-28 | 2003-01-31 | Lundbeck & Co As H | Processo para a preparacao de citalopram puro |
GB0105627D0 (en) * | 2001-03-07 | 2001-04-25 | Cipla Ltd | Preparation of phthalanes |
HUP0400095A3 (en) * | 2001-03-09 | 2005-10-28 | Ranbaxy Lab Ltd | Process for the preparation of citalopram |
US6967259B2 (en) * | 2001-09-24 | 2005-11-22 | Pharmachem Technologies Limited | Process for the preparation of Citalopram intermediate |
NZ532478A (en) * | 2001-11-08 | 2007-02-23 | Sepracor Inc | Methods for treating depression and other CNS disorders using enantiomerically enriched desmethyl- and didesmethyl-metabolites of citalopram |
WO2003057132A2 (en) * | 2002-01-07 | 2003-07-17 | Sun Pharmaceutical Industries Limited | Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile |
GB0204607D0 (en) * | 2002-02-27 | 2002-04-10 | Matrix Lab Ltd | Process |
WO2004046067A2 (en) * | 2002-11-15 | 2004-06-03 | Akzo Nobel N.V. | Purification/decolorization treatment for fatty nitriles |
US20050154052A1 (en) * | 2003-03-24 | 2005-07-14 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
EP1486492A3 (en) * | 2003-06-10 | 2005-02-23 | Sun Pharmaceuticals Industries Ltd. | A process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran. |
AU2003278409A1 (en) * | 2003-10-28 | 2005-05-19 | Krishnaji Upadhye Bhargav | Improved process for the manufacture of citalopram hydrobromide |
CN100569765C (zh) | 2003-12-19 | 2009-12-16 | 杭州民生药业集团有限公司 | 西酞普兰中间体晶体碱 |
TWI347942B (en) * | 2005-06-22 | 2011-09-01 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
CN114763343A (zh) * | 2021-01-14 | 2022-07-19 | 浙江华海药业股份有限公司 | 一种西酞普兰或s-西酞普兰的纯化方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2657013A1 (de) * | 1976-01-14 | 1977-07-28 | Kefalas As | Phthalanderivate und verfahren zu deren herstellung sowie diese enthaltende pharmazeutische mittel |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE536169C (de) * | 1926-08-21 | 1931-10-20 | British Dyestuffs Corp Ltd | Verfahren zur Gewinnung von tertiaeren aromatischen Aminen aus ihren Gemischen mit sekundaeren und primaeren aromatischen Aminen |
US1992111A (en) * | 1931-06-20 | 1935-02-19 | Du Pont | Separation of secondary and tertiary amines |
DE1032261B (de) * | 1955-03-08 | 1958-06-19 | Leda Chemicals Ltd | Verfahren zur Abtrennung sekundaerer Amine aus einer primaeres und sekundaeres Amin enthaltenden Mischung |
GB1143702A (el) | 1965-03-18 | |||
US4302399A (en) * | 1978-09-28 | 1981-11-24 | Dynapol | Acetylation of crude reaction products containing polymeric colorants |
GB8419963D0 (en) | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
US4943591A (en) | 1984-10-17 | 1990-07-24 | Glaxo Group Limited | Dichloroaniline derivatives |
DE3926765A1 (de) * | 1989-08-12 | 1991-02-14 | Hoechst Ag | Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin |
DK213290D0 (da) * | 1990-09-06 | 1990-09-06 | Lundbeck & Co As H | Treatment of cerebrovascular disorders |
US5296507A (en) | 1990-09-06 | 1994-03-22 | H.Lundbeck A/S | Treatment of cerbrovascular disorders |
DE19626659A1 (de) | 1996-07-03 | 1998-01-08 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
DE19627697A1 (de) | 1996-07-10 | 1998-01-15 | Basf Ag | Verfahren zur Herstellung von Phthaliden |
WO1999000548A1 (en) * | 1997-06-30 | 1999-01-07 | Beloit Technologies, Inc. | Method and apparatus for the high speed application of coating to a traveling paper web |
PT1015416E (pt) | 1997-07-08 | 2002-03-28 | Lundbeck & Co As H | Metodo para a producao de citalopram |
UA62985C2 (en) | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
AU738359B2 (en) * | 1997-11-11 | 2001-09-13 | H. Lundbeck A/S | Method for the preparation of citalopram |
HU228576B1 (en) | 1998-10-20 | 2013-04-29 | Lundbeck & Co As H | Method for the preparation of citalopram |
CA2356188C (en) | 1998-12-23 | 2006-05-23 | H. Lundbeck A/S | Method for the preparation of 5-cyanophthalide |
AR022329A1 (es) | 1999-01-29 | 2002-09-04 | Lundbeck & Co As H | Metodo para la preparacion de 5-cianoftalida |
TR200102957T2 (tr) | 1999-04-14 | 2004-12-21 | H. Lundbeck A/S | Sitalopram hazırlanması için metod. |
ITMI991579A1 (it) * | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
ITMI991581A1 (it) * | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
ITMI991486A1 (it) * | 1999-07-06 | 2001-01-06 | Vis Farmaceutici S P A | Processo per la sintesi di citalopram |
ES2169709A1 (es) | 1999-10-25 | 2002-07-01 | Lundbeck & Co As H | Metodo para la preparacion de citalopram |
US6310222B1 (en) | 1999-11-01 | 2001-10-30 | Sumika Fine Chemicals Co., Ltd. | Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate |
IES20010143A2 (en) | 2000-02-24 | 2001-07-25 | Lundbeck & Co As H | Method for the preparation of citalopram |
FR2805812A1 (fr) | 2000-02-24 | 2001-09-07 | Lundbeck & Co As H | Procede de preparation du citalopram |
GB0005477D0 (en) | 2000-03-07 | 2000-04-26 | Resolution Chemicals Limited | Process for the preparation of citalopram |
GB2357762B (en) * | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
IL144817A0 (en) | 2000-08-18 | 2002-06-30 | Lundbeck & Co As H | Method for the preparation of citalopram |
PT1181272E (pt) | 2000-12-28 | 2003-01-31 | Lundbeck & Co As H | Processo para a preparacao de citalopram puro |
-
2001
- 2001-03-07 EP EP01913726A patent/EP1181713B1/en not_active Expired - Lifetime
- 2001-03-07 PT PT01913726T patent/PT1181713E/pt unknown
- 2001-03-07 EP EP04004482A patent/EP1462447A3/en not_active Withdrawn
- 2001-03-07 AT AT01913726T patent/ATE277920T1/de not_active IP Right Cessation
- 2001-03-07 EA EA200200018A patent/EA003581B1/ru not_active IP Right Cessation
- 2001-03-07 WO PCT/DK2001/000147 patent/WO2001045483A2/en active Application Filing
- 2001-03-07 ES ES01913726T patent/ES2228824T3/es not_active Expired - Lifetime
- 2001-03-07 AU AU2001100405A patent/AU2001100405B4/en not_active Ceased
- 2001-03-07 TR TR2002/01166T patent/TR200201166T1/xx unknown
- 2001-03-07 CN CNB018011225A patent/CN1282648C/zh not_active Expired - Lifetime
- 2001-03-07 MX MXPA01013151A patent/MXPA01013151A/es active IP Right Grant
- 2001-03-07 SG SG200504030-8A patent/SG167655A1/en unknown
- 2001-03-07 BR BR0106272-7A patent/BR0106272A/pt not_active Application Discontinuation
- 2001-03-07 DE DE60105926T patent/DE60105926T2/de not_active Expired - Lifetime
- 2001-03-07 DK DK01913726T patent/DK1181713T3/da active
- 2001-03-07 IL IL147226A patent/IL147226A/en not_active IP Right Cessation
- 2001-03-07 AU AU39201/01A patent/AU3920101A/en active Pending
- 2001-03-07 PL PL353398A patent/PL205724B1/pl not_active IP Right Cessation
- 2001-03-07 KR KR10-2001-7016686A patent/KR100439329B1/ko not_active IP Right Cessation
- 2001-03-07 CA CA002360303A patent/CA2360303C/en not_active Expired - Fee Related
- 2001-03-07 NL NL1017525A patent/NL1017525C1/nl not_active IP Right Cessation
- 2001-03-07 SK SK1848-2001A patent/SK284428B6/sk not_active IP Right Cessation
- 2001-03-07 JP JP2001546230A patent/JP3798982B2/ja not_active Expired - Fee Related
- 2001-03-07 SK SK4-2005A patent/SK286283B6/sk not_active IP Right Cessation
- 2001-03-07 SI SI200130238T patent/SI1181713T1/xx unknown
- 2001-03-09 IS IS5883A patent/IS2060B/xx unknown
- 2001-03-09 HU HU0101029A patent/HU0101029D0/hu unknown
- 2001-03-12 CZ CZ2001890A patent/CZ292200B6/cs not_active IP Right Cessation
- 2001-03-12 GB GB0105983A patent/GB2357763B/en not_active Revoked
- 2001-03-13 NO NO20011271A patent/NO312462B1/no not_active IP Right Cessation
- 2001-03-13 FI FI20010500A patent/FI108639B/fi not_active IP Right Cessation
- 2001-03-14 FR FR0103455A patent/FR2812877B1/fr not_active Expired - Fee Related
- 2001-03-15 IE IE20010254A patent/IES20010254A2/en not_active IP Right Cessation
- 2001-03-15 AR ARP010101209A patent/AR030056A1/es not_active Application Discontinuation
- 2001-03-16 GR GR20010100132A patent/GR1003874B/el not_active IP Right Cessation
- 2001-03-16 DE DE10112829A patent/DE10112829C1/de not_active Expired - Fee Related
- 2001-03-21 AT AT0020801U patent/AT4367U1/de not_active IP Right Cessation
- 2001-03-22 CH CH00545/01A patent/CH691535A5/de not_active IP Right Cessation
- 2001-03-22 IT IT2001MI000602A patent/ITMI20010602A1/it unknown
- 2001-03-22 BE BE2001/0188A patent/BE1013212A6/fr not_active IP Right Cessation
- 2001-06-22 NL NL1018360A patent/NL1018360C1/nl not_active IP Right Cessation
- 2001-06-26 BE BE2001/0435A patent/BE1013213A6/fr not_active IP Right Cessation
- 2001-07-03 UA UA2002021552A patent/UA71634C2/uk unknown
- 2001-07-05 HU HU0102817A patent/HUP0102817A3/hu unknown
- 2001-07-26 FI FI20011577A patent/FI20011577A0/fi unknown
- 2001-07-27 ES ES200101762A patent/ES2170732B2/es not_active Expired - Fee Related
- 2001-09-14 SE SE0103045A patent/SE517623C2/sv not_active IP Right Cessation
- 2001-12-10 BG BG106203A patent/BG65131B1/bg unknown
- 2001-12-11 ZA ZA200110179A patent/ZA200110179B/xx unknown
- 2001-12-20 NZ NZ516298A patent/NZ516298A/xx unknown
-
2002
- 2002-01-04 HR HR20020004A patent/HRP20020004A2/hr not_active Application Discontinuation
- 2002-01-08 US US10/046,126 patent/US6455710B1/en not_active Expired - Fee Related
-
2003
- 2003-02-10 HK HK03100966.7A patent/HK1048812B/zh not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2657013A1 (de) * | 1976-01-14 | 1977-07-28 | Kefalas As | Phthalanderivate und verfahren zu deren herstellung sowie diese enthaltende pharmazeutische mittel |
Non-Patent Citations (3)
Title |
---|
BIGLER A J ET AL: "QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS IN A SERIES OF SELECTIVE 5-HT UPTAKE INHIBITORS", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 12, no. 3, May 1977 (1977-05-01), pages 289 - 295, XP000944915, ISSN: 0223-5234 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; MAURER, HANS H. ET AL: "Screening procedure for detection of antidepressants of the selective serotonin reuptake inhibitor type and their metabolites in urine as part of a modified systematic toxicological analysis procedure using gas chromatography-mass spectrometry", XP002177886, retrieved from STN Database accession no. 133:262408 * |
J. ANAL. TOXICOL. (2000), 24(5), 340-347 * |
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Legal Events
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PG | Patent granted | ||
ML | Lapse due to non-payment of fees |
Effective date: 20111004 |