ES2054681T3 - Procedimiento para la preparacion de derivados de 2-indolinona. - Google Patents
Procedimiento para la preparacion de derivados de 2-indolinona.Info
- Publication number
- ES2054681T3 ES2054681T3 ES87307510T ES87307510T ES2054681T3 ES 2054681 T3 ES2054681 T3 ES 2054681T3 ES 87307510 T ES87307510 T ES 87307510T ES 87307510 T ES87307510 T ES 87307510T ES 2054681 T3 ES2054681 T3 ES 2054681T3
- Authority
- ES
- Spain
- Prior art keywords
- 6alkyl
- hydrogen
- compound
- preparation
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Glass Compositions (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
Abstract
UN PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO DE LA ESTRUCTURA (I) EN EL QUE, CADA GRUPO R ES HIDROGENO, ALQUILO C1-6, ALILO C3-6, FENIL-ALQUILO C1-6 O 4-HIDROXIFENILALQUILO C1-6; R1, R2 Y R3 SON HIDROGENO O ALQUILO C1-6; R4 ES HIDROGENO O HIDROXI; Y N ES DE 1 A 3, Y DE UNA SAL DEL MISMO FARMACOLOGICAMENTE ACEPTABLE. EL PROCEDIMIENTO COMPRENDE LA REDUCCION DE UN COMPUESTO DE ESTRUCTURA (II) EN DONDE R, R2 A R4 Y N SON COMO SE HAN DESCRITO ANTES Y R5 ES HIDROGENO O UN CATION, SEGUIDA POR LA CICLACION DELPRODUCTO INTERMEDIOASI FORMADO Y, OPCIONALMENTE, LA ALQUILACION PARA FORMAR UN COMPUESTO DE ESTRUCTURA (I) EN DONDE R1 ES ALQUILO C1-6 Y, OPCIONALMENTE, LA FORMACION DE UNA SAL DEL MISMO FARMACOLOGICAMENTE ACEPTABLE. SE CARACTERIZA PORQUE LA REDUCCION DEL COMPUESTO DE ESTRUCTURA (II) SE REALIZA POR HIDROGENACION DE TRANSFERENCIA CATALITICA EN AGUA COMO DISOLVENTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868621040A GB8621040D0 (en) | 1986-08-30 | 1986-08-30 | Process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2054681T3 true ES2054681T3 (es) | 1994-08-16 |
Family
ID=10603475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES87307510T Expired - Lifetime ES2054681T3 (es) | 1986-08-30 | 1987-08-25 | Procedimiento para la preparacion de derivados de 2-indolinona. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4950765A (es) |
| EP (1) | EP0266033B1 (es) |
| JP (1) | JPH0768212B2 (es) |
| KR (1) | KR100233397B1 (es) |
| CN (1) | CN1016342B (es) |
| AT (1) | ATE107631T1 (es) |
| AU (1) | AU593130B2 (es) |
| CA (1) | CA1305711C (es) |
| DE (1) | DE3750117T2 (es) |
| DK (1) | DK170372B1 (es) |
| ES (1) | ES2054681T3 (es) |
| GB (1) | GB8621040D0 (es) |
| HK (1) | HK1004550A1 (es) |
| HU (1) | HU199414B (es) |
| IE (1) | IE64176B1 (es) |
| PT (1) | PT85585B (es) |
| ZA (1) | ZA876397B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW457233B (en) * | 1996-10-11 | 2001-10-01 | Bristol Myers Squibb Co | Preparation of 3-fluoro oxindole derivatives |
| WO2005074387A2 (en) * | 2003-12-30 | 2005-08-18 | Sun Pharmaceutical Industries Limited | Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride |
| WO2005105741A1 (en) * | 2004-02-11 | 2005-11-10 | Sun Pharmaceutical Industries Limited | Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride |
| WO2011072704A1 (en) | 2009-12-16 | 2011-06-23 | Pharmathen S.A. | Process for the preparation of ropinirole and salts thereof |
| EP3428247A1 (en) | 2014-10-24 | 2019-01-16 | Neste Oil Oyj | Method for ketonisation of biological material |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4452808A (en) * | 1982-12-07 | 1984-06-05 | Smithkline Beckman Corporation | 4-Aminoalkyl-2(3H)-indolones |
-
1986
- 1986-08-30 GB GB868621040A patent/GB8621040D0/en active Pending
-
1987
- 1987-08-24 CA CA000545203A patent/CA1305711C/en not_active Expired - Lifetime
- 1987-08-24 CN CN87105873A patent/CN1016342B/zh not_active Expired
- 1987-08-24 US US07/088,774 patent/US4950765A/en not_active Expired - Lifetime
- 1987-08-25 DK DK443587A patent/DK170372B1/da not_active IP Right Cessation
- 1987-08-25 DE DE3750117T patent/DE3750117T2/de not_active Expired - Lifetime
- 1987-08-25 EP EP87307510A patent/EP0266033B1/en not_active Expired - Lifetime
- 1987-08-25 AT AT87307510T patent/ATE107631T1/de not_active IP Right Cessation
- 1987-08-25 ES ES87307510T patent/ES2054681T3/es not_active Expired - Lifetime
- 1987-08-25 PT PT85585A patent/PT85585B/pt unknown
- 1987-08-26 JP JP62212628A patent/JPH0768212B2/ja not_active Expired - Lifetime
- 1987-08-27 AU AU77615/87A patent/AU593130B2/en not_active Expired
- 1987-08-27 ZA ZA876397A patent/ZA876397B/xx unknown
- 1987-08-27 KR KR1019870009359A patent/KR100233397B1/ko not_active IP Right Cessation
- 1987-08-28 HU HU873793A patent/HU199414B/hu unknown
- 1987-08-28 IE IE230987A patent/IE64176B1/en not_active IP Right Cessation
-
1998
- 1998-04-29 HK HK98103672A patent/HK1004550A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0768212B2 (ja) | 1995-07-26 |
| KR880002825A (ko) | 1988-05-11 |
| DK443587D0 (da) | 1987-08-25 |
| JPS6363658A (ja) | 1988-03-22 |
| EP0266033B1 (en) | 1994-06-22 |
| CA1305711C (en) | 1992-07-28 |
| CN1016342B (zh) | 1992-04-22 |
| HK1004550A1 (en) | 1998-11-27 |
| ZA876397B (en) | 1988-02-25 |
| CN87105873A (zh) | 1988-03-09 |
| IE64176B1 (en) | 1995-07-12 |
| EP0266033A2 (en) | 1988-05-04 |
| KR100233397B1 (ko) | 2000-02-01 |
| DE3750117D1 (de) | 1994-07-28 |
| DK170372B1 (da) | 1995-08-14 |
| DK443587A (da) | 1988-03-01 |
| PT85585A (en) | 1987-09-01 |
| GB8621040D0 (en) | 1986-10-08 |
| PT85585B (pt) | 1990-05-31 |
| AU593130B2 (en) | 1990-02-01 |
| HU199414B (en) | 1990-02-28 |
| ATE107631T1 (de) | 1994-07-15 |
| AU7761587A (en) | 1988-03-03 |
| US4950765A (en) | 1990-08-21 |
| IE872309L (en) | 1988-02-29 |
| DE3750117T2 (de) | 1994-10-06 |
| EP0266033A3 (en) | 1989-01-25 |
| HUT45012A (en) | 1988-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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