ES8501763A1 - "procedimiento para la fabricacion de derivados de la tetrahidro-5.6.7.7. 4h-tieno (3, 2-c) piridinona-2 - Google Patents

"procedimiento para la fabricacion de derivados de la tetrahidro-5.6.7.7. 4h-tieno (3, 2-c) piridinona-2

Info

Publication number
ES8501763A1
ES8501763A1 ES523226A ES523226A ES8501763A1 ES 8501763 A1 ES8501763 A1 ES 8501763A1 ES 523226 A ES523226 A ES 523226A ES 523226 A ES523226 A ES 523226A ES 8501763 A1 ES8501763 A1 ES 8501763A1
Authority
ES
Spain
Prior art keywords
preparation
thienopyridinone
therapeutic use
novel derivative
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523226A
Other languages
English (en)
Other versions
ES523226A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Publication of ES8501763A1 publication Critical patent/ES8501763A1/es
Publication of ES523226A0 publication Critical patent/ES523226A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS DE TETRAHIDRO-5,6,7,7A 4H-TIENO-(3,2-C)-PIRIDINONA-2, DE FORMULA (I).CONSISTE EN LA REACCION DE NITRACION DEL COMPUESTO DE FORMULA (II) CON NITRITO SODICO EN ACIDO ACETICO GLACIAL Y BAJO ATMOSFERA INERTE; SEGUIDA DE LA HIDROGENACION DE LA CETO-OXIMA FORMADA, EN PRESENCIA DE UN CATALIZADOR Y ACIDO PERCLORICO; Y TRATAMIENTO CON ACIDO CLORHIDRICO 2N, A REFLUJO.ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANTIAGREGANTES PLAQUETARIAS Y ANTITROMBOTICAS.
ES523226A 1982-06-16 1983-06-14 "procedimiento para la fabricacion de derivados de la tetrahidro-5.6.7.7. 4h-tieno (3, 2-c) piridinona-2 Granted ES523226A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8210926A FR2528848A1 (fr) 1982-06-16 1982-06-16 Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique

Publications (2)

Publication Number Publication Date
ES8501763A1 true ES8501763A1 (es) 1984-12-16
ES523226A0 ES523226A0 (es) 1984-12-16

Family

ID=9275281

Family Applications (1)

Application Number Title Priority Date Filing Date
ES523226A Granted ES523226A0 (es) 1982-06-16 1983-06-14 "procedimiento para la fabricacion de derivados de la tetrahidro-5.6.7.7. 4h-tieno (3, 2-c) piridinona-2

Country Status (28)

Country Link
US (1) US4500534A (es)
EP (1) EP0097079B1 (es)
JP (1) JPS6041076B2 (es)
KR (1) KR870000207B1 (es)
AT (1) ATE22563T1 (es)
AU (1) AU555855B2 (es)
CA (1) CA1200551A (es)
CS (1) CS235041B2 (es)
DD (1) DD210051A5 (es)
DE (1) DE3366558D1 (es)
DK (1) DK267183A (es)
EG (1) EG16053A (es)
ES (1) ES523226A0 (es)
FI (1) FI73217C (es)
FR (1) FR2528848A1 (es)
GR (1) GR78286B (es)
HU (1) HU186330B (es)
IE (1) IE55458B1 (es)
IL (1) IL68916A (es)
NO (1) NO159092C (es)
NZ (1) NZ204584A (es)
OA (1) OA07460A (es)
PH (1) PH19864A (es)
PL (1) PL139772B1 (es)
PT (1) PT76872B (es)
SU (1) SU1207394A3 (es)
YU (1) YU43185B (es)
ZA (1) ZA834088B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576901B1 (fr) * 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
FR2596392B1 (fr) * 1986-03-27 1988-08-05 Sanofi Sa Derives de l'acide a-(hydroxy-3 oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenylacetique, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
US5980954A (en) 1992-02-07 1999-11-09 Vasogen Ireland Limited Treatment of autoimmune diseases
US6204058B1 (en) 1992-02-07 2001-03-20 Vasogen Ireland Limited Treatment of autoimmune diseases
US5591457A (en) * 1992-02-07 1997-01-07 Vasogen Inc Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human
GB9617611D0 (en) * 1996-08-22 1996-10-02 Vasogen Inc Treatment of autoimmune disease
US6669965B2 (en) 1992-02-07 2003-12-30 Vasogen Ireland Limited Method of treating atherosclerosis
CN100341506C (zh) * 2000-12-25 2007-10-10 三共株式会社 含有阿斯匹林的药用组合物
CN1571634A (zh) * 2001-08-23 2005-01-26 免疫公司 用于分析的细胞和生物学标本的稳定
EP1903042A3 (en) * 2006-09-22 2008-05-28 Cadila Pharmaceuticals Limited An improved process for hydrogenation of 5-(substituted Benzylidene) 2,4- Thiazolidine Dione compounds to give corresponding ( +/- ) 5- (substituted Benzyl ) 2,4-Thiazolidine Dione

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2495157A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Procede nouveau de preparation des tetrahydro-5, 6, 7, 7a 4h-thieno (3, 2-c) pyridinones-2
FR2495156A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique

Also Published As

Publication number Publication date
NO159092B (no) 1988-08-22
YU43185B (en) 1989-04-30
FI832208A0 (fi) 1983-06-16
SU1207394A3 (ru) 1986-01-23
ZA834088B (en) 1984-02-29
EP0097079A1 (fr) 1983-12-28
EP0097079B1 (fr) 1986-10-01
NZ204584A (en) 1985-08-30
FR2528848A1 (fr) 1983-12-23
HU186330B (en) 1985-07-29
YU133383A (en) 1986-02-28
PT76872B (fr) 1986-01-27
KR870000207B1 (ko) 1987-02-16
DD210051A5 (de) 1984-05-30
IL68916A0 (en) 1983-10-31
CA1200551A (fr) 1986-02-11
FI832208L (fi) 1983-12-17
OA07460A (fr) 1987-01-31
PT76872A (fr) 1983-07-01
GR78286B (es) 1984-09-26
DK267183A (da) 1983-12-17
ATE22563T1 (de) 1986-10-15
FI73217B (fi) 1987-05-29
EG16053A (en) 1989-01-30
PL139772B1 (en) 1987-02-28
IL68916A (en) 1986-11-30
JPS597192A (ja) 1984-01-14
FR2528848B1 (es) 1984-11-23
DK267183D0 (da) 1983-06-10
FI73217C (fi) 1987-09-10
AU555855B2 (en) 1986-10-09
JPS6041076B2 (ja) 1985-09-13
NO159092C (no) 1988-11-30
AU1546983A (en) 1983-12-22
US4500534A (en) 1985-02-19
PL242534A1 (en) 1984-08-13
IE55458B1 (en) 1990-09-26
DE3366558D1 (en) 1986-11-06
NO832164L (no) 1983-12-19
KR840005147A (ko) 1984-11-03
IE831407L (en) 1983-12-16
PH19864A (en) 1986-08-13
CS235041B2 (en) 1985-04-16
ES523226A0 (es) 1984-12-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303