KR840005147A - 신규 티에노-피리디논 유도체의 제조방법 - Google Patents

신규 티에노-피리디논 유도체의 제조방법 Download PDF

Info

Publication number
KR840005147A
KR840005147A KR1019830002587A KR830002587A KR840005147A KR 840005147 A KR840005147 A KR 840005147A KR 1019830002587 A KR1019830002587 A KR 1019830002587A KR 830002587 A KR830002587 A KR 830002587A KR 840005147 A KR840005147 A KR 840005147A
Authority
KR
South Korea
Prior art keywords
following structural
structural formula
acid
carried out
therapeutic composition
Prior art date
Application number
KR1019830002587A
Other languages
English (en)
Other versions
KR870000207B1 (ko
Inventor
프레엘 다니엘 (외 2)
Original Assignee
원본미기재
사노피 소시에테 아노님
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 원본미기재, 사노피 소시에테 아노님 filed Critical 원본미기재
Publication of KR840005147A publication Critical patent/KR840005147A/ko
Application granted granted Critical
Publication of KR870000207B1 publication Critical patent/KR870000207B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

신규 티에노-피리디논 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 다음 구조식(II)의 화합물을 니트로소화 하여 얻어진 다음 구조식(III)의 케토-옥심을 수소 첨가한 다음, 얻어진 다음 구조식(IV)의 수소 첨가 유도체를 산처리시키는 것으로 구성된 다음 구조식(I)의 5,6,7,7a-테트라하이드로-4H-티에노(3,2-C)피리딘-2-온유도체 및 그의 제약적으로 허용되는 무기 또는 유기산 부가염을 제조하는 방법.
  2. 제1항에 있어서, 니트로소화를 불활성 분위기하에 빙초산 매질에서 아질산나트륨으로 수행함을 특징으로 하는 상기 구조식(I)의 화합물의 제조방법.
  3. 제2항에 있어서, 수소 첨가를 촉매 및 과염소산의 존재하에 수행함을 특징으로 하는 상기 구조식(I)의 화합물을 제조하는 방법.
  4. 제2항에 있어서 산처리를 불활성 분위기하에 환류조건하에서 2N농도의 염산으로 수행함을 특징으로 하는 상기 구조식(I)의 화합물의 제조방법.
  5. 유효성분으로서 제1항의 유도체를 함유하며 특히 항-혈소판 응집작용과 항-혈전증 작용을 갖는 치료용 조성물.
  6. 제5항에 있어서, 경구, 비경구 또는 직장 투여에 적합한 형태로 제형화 함을 특징으로 하는 치료용 조성물.
  7. 제5항 또는 제6항중의 어느 하나에 있어서, 투약단위 형태에 있어서 각 단위 투약량이 0.010g 내지 0.005g의 유효성분을 함유 함을 특징으로 하는 치료용 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830002587A 1982-06-16 1983-06-10 티에노-피리디논 유도체의 제조방법 KR870000207B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8210926A FR2528848A1 (fr) 1982-06-16 1982-06-16 Nouveau derive de thieno-pyridone, son procede de preparation et son application therapeutique
FR8210926 1982-06-16

Publications (2)

Publication Number Publication Date
KR840005147A true KR840005147A (ko) 1984-11-03
KR870000207B1 KR870000207B1 (ko) 1987-02-16

Family

ID=9275281

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830002587A KR870000207B1 (ko) 1982-06-16 1983-06-10 티에노-피리디논 유도체의 제조방법

Country Status (28)

Country Link
US (1) US4500534A (ko)
EP (1) EP0097079B1 (ko)
JP (1) JPS6041076B2 (ko)
KR (1) KR870000207B1 (ko)
AT (1) ATE22563T1 (ko)
AU (1) AU555855B2 (ko)
CA (1) CA1200551A (ko)
CS (1) CS235041B2 (ko)
DD (1) DD210051A5 (ko)
DE (1) DE3366558D1 (ko)
DK (1) DK267183A (ko)
EG (1) EG16053A (ko)
ES (1) ES523226A0 (ko)
FI (1) FI73217C (ko)
FR (1) FR2528848A1 (ko)
GR (1) GR78286B (ko)
HU (1) HU186330B (ko)
IE (1) IE55458B1 (ko)
IL (1) IL68916A (ko)
NO (1) NO159092C (ko)
NZ (1) NZ204584A (ko)
OA (1) OA07460A (ko)
PH (1) PH19864A (ko)
PL (1) PL139772B1 (ko)
PT (1) PT76872B (ko)
SU (1) SU1207394A3 (ko)
YU (1) YU43185B (ko)
ZA (1) ZA834088B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576901B1 (fr) * 1985-01-31 1987-03-20 Sanofi Sa Nouveaux derives de l'acide a-(oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenyl acetique, leur procede de preparation et leur application therapeutique
FR2596392B1 (fr) * 1986-03-27 1988-08-05 Sanofi Sa Derives de l'acide a-(hydroxy-3 oxo-2 hexahydro-2,4,5,6,7,7a thieno (3,2-c) pyridyl-5) phenylacetique, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
US5980954A (en) 1992-02-07 1999-11-09 Vasogen Ireland Limited Treatment of autoimmune diseases
US6204058B1 (en) 1992-02-07 2001-03-20 Vasogen Ireland Limited Treatment of autoimmune diseases
US5591457A (en) * 1992-02-07 1997-01-07 Vasogen Inc Method of inhibiting the aggregation of blood platelets and stimulating the immune systems of a human
GB9617611D0 (en) * 1996-08-22 1996-10-02 Vasogen Inc Treatment of autoimmune disease
US6669965B2 (en) 1992-02-07 2003-12-30 Vasogen Ireland Limited Method of treating atherosclerosis
CN100341506C (zh) * 2000-12-25 2007-10-10 三共株式会社 含有阿斯匹林的药用组合物
CN1571634A (zh) * 2001-08-23 2005-01-26 免疫公司 用于分析的细胞和生物学标本的稳定
EP1903042A3 (en) * 2006-09-22 2008-05-28 Cadila Pharmaceuticals Limited An improved process for hydrogenation of 5-(substituted Benzylidene) 2,4- Thiazolidine Dione compounds to give corresponding ( +/- ) 5- (substituted Benzyl ) 2,4-Thiazolidine Dione

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2495157A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Procede nouveau de preparation des tetrahydro-5, 6, 7, 7a 4h-thieno (3, 2-c) pyridinones-2
FR2495156A1 (fr) * 1980-11-28 1982-06-04 Sanofi Sa Derives de la thieno-pyridinone, leur procede de preparation et leur application therapeutique

Also Published As

Publication number Publication date
ES8501763A1 (es) 1984-12-16
NO159092B (no) 1988-08-22
YU43185B (en) 1989-04-30
FI832208A0 (fi) 1983-06-16
SU1207394A3 (ru) 1986-01-23
ZA834088B (en) 1984-02-29
EP0097079A1 (fr) 1983-12-28
EP0097079B1 (fr) 1986-10-01
NZ204584A (en) 1985-08-30
FR2528848A1 (fr) 1983-12-23
HU186330B (en) 1985-07-29
YU133383A (en) 1986-02-28
PT76872B (fr) 1986-01-27
KR870000207B1 (ko) 1987-02-16
DD210051A5 (de) 1984-05-30
IL68916A0 (en) 1983-10-31
CA1200551A (fr) 1986-02-11
FI832208L (fi) 1983-12-17
OA07460A (fr) 1987-01-31
PT76872A (fr) 1983-07-01
GR78286B (ko) 1984-09-26
DK267183A (da) 1983-12-17
ATE22563T1 (de) 1986-10-15
FI73217B (fi) 1987-05-29
EG16053A (en) 1989-01-30
PL139772B1 (en) 1987-02-28
IL68916A (en) 1986-11-30
JPS597192A (ja) 1984-01-14
FR2528848B1 (ko) 1984-11-23
DK267183D0 (da) 1983-06-10
FI73217C (fi) 1987-09-10
AU555855B2 (en) 1986-10-09
JPS6041076B2 (ja) 1985-09-13
NO159092C (no) 1988-11-30
AU1546983A (en) 1983-12-22
US4500534A (en) 1985-02-19
PL242534A1 (en) 1984-08-13
IE55458B1 (en) 1990-09-26
DE3366558D1 (en) 1986-11-06
NO832164L (no) 1983-12-19
IE831407L (en) 1983-12-16
PH19864A (en) 1986-08-13
CS235041B2 (en) 1985-04-16
ES523226A0 (es) 1984-12-16

Similar Documents

Publication Publication Date Title
PT77018A (fr) Procede de preparation de nouveaux derives de la thieno (3,2-c) pyridine et de compositions pharmaceutiques les contenant
NO940523D0 (no) Nye pyrazin-derivater
FI810604L (fi) Foerfarande foer framstaellning av indanderivat
KR840005147A (ko) 신규 티에노-피리디논 유도체의 제조방법
GB1305795A (ko)
ATE13297T1 (de) Piperidyliden-derivate, deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
SE8703169D0 (sv) 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5h-2,3-benzodiazepine, acid addition salts thereof and process for preparing same
KR940005274A (ko) 쇼그렌(Sjoegren)증후군 치료제
GB1148717A (en) Phenylbenz (f)-2,5-oxazocine derivatives and homologues and pharmaceutical compositions
ATE59632T1 (de) Dihydrodibenzocycloheptylidenethylamin-derivate
KR890014480A (ko) 2-피리딜아세트산 유도체, 이의 제조방법 및 이를 함유하는 약제학적 조성물
DE3869075D1 (de) 2-piperazinyl-2-oxo-aethylensubstituierte flavonoid-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammenstellungen.
KR900700098A (ko) 발기부전의 치료겸 진단용 플라복세이트 및 그 유도체
ES8600240A1 (es) Metodo para preparar derivados de fenilindeno
CO4970779A1 (es) Derivados del acido aminoetilfenoxiacetico y agentes para reducir el dolor y promover la eliminacion de calculos en urolitiasis
ATE13523T1 (de) 11-deoxoglycyrrhetinsaeurehydrogenmaleinat, verfahren zu dessen herstellung und seine verwendung als medikament.
CH616935A5 (en) Process for the preparation of chromone derivatives
KR850006429A (ko) 새로운 시아노이미다졸 누클레오시드 유도체 및 그 제조방법
KR890001941A (ko) 3,5-디하이드록시카복실산 및 이의 유도체, 이의 제조방법, 약제로서의 이의 용도, 약제학적 조성물 및 중간생성물
KR890006640A (ko) 항불안성인 r-n-(1-아자비시클로[2.2.2]옥트-3-일)벤즈아미드 및 티오벤즈아미드
KR890701584A (ko) 20, 21-디노르에비나메닌의 신규 치환 유도체, 그의 제조 방법 및 이 방법으로 얻는 신규 중간체, 약제로서의 그의 용도 및 그를 함유하는 제약 조성물
ATE48130T1 (de) Alpha-aryl-alpha-pyridylalkanoicsaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzung.
GB1085672A (en) Substituted phthalazines
KR910000777A (ko) 정균 활성을 갖는 안트라사이클린 유도체
KR870001153A (ko) 디페녹시에틸아민 유도체가 함유된 약제조성물 및 그의 생산방법

Legal Events

Date Code Title Description
E701 Decision to grant or registration of patent right