ES8105291A1 - Procedimiento para la obtencion de derivados del decahidro- quinolinol - Google Patents
Procedimiento para la obtencion de derivados del decahidro- quinolinolInfo
- Publication number
- ES8105291A1 ES8105291A1 ES495153A ES495153A ES8105291A1 ES 8105291 A1 ES8105291 A1 ES 8105291A1 ES 495153 A ES495153 A ES 495153A ES 495153 A ES495153 A ES 495153A ES 8105291 A1 ES8105291 A1 ES 8105291A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- phenyl radical
- phenyl
- preparation
- substituent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE DECAHIDROQUINOLINOL. CONSTA DE LAS SIGUIENTES ETAPAS: 1. REACCION DE UNA 4-HIDROXI-TRANS, DECAHIDROQUINOLINA N-SUSTITUIDA DE FORMULA GENERAL (I) CON UN COMPUESTO II, EN UN DISOLVENTE INSERTO TAL COMO BENCENO, TOLUENO, DICLOROMETANO O UNA MEZCLA DE LOS MISMOS; LA REACCION SE EFECTUA A TEMPERATURA AMBIENTE. SE OBTIENE UN COMPUESTO III, 2. CONDENSACION DEL PRODUCTO ANTERIOR CON AMONIACO O UNA AMINA PRIMARIA DE FORMULA H2-N-R ELEVADO A 1 EN UN DISOLVENTE INERTE Y A TEMPERATURA AMBIENTE, FORMANDOSE EL CORRESPONDIENTE ESTER CARBAMICO DE DECAHIDROQUINOLINOL EN FORMA DE BASE LIBRE, QUE SI SE DESEA SE TRATA CON UN ACIDO ORGANICO O INORGANICO PARA DAR LA SAL DE ADICION CORRESPONDIENTE. TRATAMIENTO DE ARRITMIAS CARDIACAS. *FORMULA*
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7923289A FR2465724A1 (fr) | 1979-09-19 | 1979-09-19 | Nouveaux derives de decahydroquinoleinol, leur procede de preparation ainsi que leurs applications en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES495153A0 ES495153A0 (es) | 1981-06-01 |
| ES8105291A1 true ES8105291A1 (es) | 1981-06-01 |
Family
ID=9229781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES495153A Expired ES8105291A1 (es) | 1979-09-19 | 1980-09-18 | Procedimiento para la obtencion de derivados del decahidro- quinolinol |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US4332805A (es) |
| EP (1) | EP0026168B1 (es) |
| JP (1) | JPS5673063A (es) |
| AR (1) | AR224652A1 (es) |
| AT (1) | AT375344B (es) |
| AU (1) | AU530427B2 (es) |
| BG (1) | BG31798A3 (es) |
| CA (1) | CA1144170A (es) |
| CS (1) | CS215072B2 (es) |
| DD (1) | DD153118A5 (es) |
| DE (1) | DE3062357D1 (es) |
| DK (1) | DK149588C (es) |
| EG (1) | EG14833A (es) |
| ES (1) | ES8105291A1 (es) |
| FI (1) | FI70705C (es) |
| FR (1) | FR2465724A1 (es) |
| GB (1) | GB2061267B (es) |
| GR (1) | GR69823B (es) |
| HU (1) | HU182204B (es) |
| IE (1) | IE50790B1 (es) |
| IL (1) | IL60913A (es) |
| IN (1) | IN152974B (es) |
| IS (1) | IS1122B6 (es) |
| MA (1) | MA18954A1 (es) |
| MC (1) | MC1346A1 (es) |
| NO (1) | NO153727C (es) |
| NZ (1) | NZ194924A (es) |
| OA (1) | OA06620A (es) |
| PH (1) | PH16992A (es) |
| PL (1) | PL123443B1 (es) |
| PT (1) | PT71808B (es) |
| RO (1) | RO80663B (es) |
| SU (1) | SU936808A3 (es) |
| YU (1) | YU239680A (es) |
| ZA (1) | ZA805164B (es) |
| ZM (1) | ZM7880A1 (es) |
| ZW (1) | ZW20880A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4425349A (en) | 1979-07-02 | 1984-01-10 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. | Sulfur-containing isoquinoline derivatives in pharmaceutical compositions and methods of use |
| FR2565979B1 (fr) * | 1984-06-13 | 1987-03-20 | Labaz Sanofi Nv | Nouveaux derives de decahydroquinoleinol, leur procede de preparation et les compositions les contenant |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791678A (fr) * | 1971-11-23 | 1973-05-21 | Labaz | Nouveaux derives de decahydroquinoleinol, leur procede de preparation ainsi que les compositions therapeutiques les contenant |
| US4173636A (en) * | 1975-12-16 | 1979-11-06 | Labaz | Decahydroquinolines, pharmaceutical compositions and methods of use |
-
1979
- 1979-09-19 FR FR7923289A patent/FR2465724A1/fr active Granted
-
1980
- 1980-08-19 MC MC801467A patent/MC1346A1/xx unknown
- 1980-08-21 ZA ZA00805164A patent/ZA805164B/xx unknown
- 1980-08-22 AU AU61687/80A patent/AU530427B2/en not_active Ceased
- 1980-08-25 IS IS2579A patent/IS1122B6/is unknown
- 1980-08-25 IL IL60913A patent/IL60913A/xx unknown
- 1980-08-27 IN IN985/CAL/80A patent/IN152974B/en unknown
- 1980-09-04 US US06/184,129 patent/US4332805A/en not_active Expired - Lifetime
- 1980-09-05 GR GR62820A patent/GR69823B/el unknown
- 1980-09-09 IE IE1888/80A patent/IE50790B1/en unknown
- 1980-09-10 ZW ZW208/80A patent/ZW20880A1/xx unknown
- 1980-09-11 NZ NZ194924A patent/NZ194924A/en unknown
- 1980-09-11 ZM ZM78/80A patent/ZM7880A1/xx unknown
- 1980-09-12 RO RO102150A patent/RO80663B/ro unknown
- 1980-09-15 FI FI802879A patent/FI70705C/fi not_active IP Right Cessation
- 1980-09-16 PT PT71808A patent/PT71808B/pt unknown
- 1980-09-17 PL PL1980226793A patent/PL123443B1/pl unknown
- 1980-09-17 PH PH24595A patent/PH16992A/en unknown
- 1980-09-17 AR AR282558A patent/AR224652A1/es active
- 1980-09-17 SU SU802980755A patent/SU936808A3/ru active
- 1980-09-18 CS CS806308A patent/CS215072B2/cs unknown
- 1980-09-18 GB GB8030202A patent/GB2061267B/en not_active Expired
- 1980-09-18 AT AT0467780A patent/AT375344B/de not_active IP Right Cessation
- 1980-09-18 BG BG8049093A patent/BG31798A3/xx unknown
- 1980-09-18 EP EP80870039A patent/EP0026168B1/fr not_active Expired
- 1980-09-18 HU HU802295A patent/HU182204B/hu unknown
- 1980-09-18 DE DE8080870039T patent/DE3062357D1/de not_active Expired
- 1980-09-18 ES ES495153A patent/ES8105291A1/es not_active Expired
- 1980-09-18 DK DK395680A patent/DK149588C/da active
- 1980-09-18 NO NO802775A patent/NO153727C/no unknown
- 1980-09-18 YU YU02396/80A patent/YU239680A/xx unknown
- 1980-09-18 CA CA000360502A patent/CA1144170A/en not_active Expired
- 1980-09-19 MA MA19155A patent/MA18954A1/fr unknown
- 1980-09-19 DD DD80224021A patent/DD153118A5/de unknown
- 1980-09-19 JP JP13144280A patent/JPS5673063A/ja active Pending
- 1980-09-19 OA OA57214A patent/OA06620A/xx unknown
- 1980-09-20 EG EG578/80A patent/EG14833A/xx active
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