ES8403877A1 - Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol. - Google Patents
Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol.Info
- Publication number
- ES8403877A1 ES8403877A1 ES515766A ES515766A ES8403877A1 ES 8403877 A1 ES8403877 A1 ES 8403877A1 ES 515766 A ES515766 A ES 515766A ES 515766 A ES515766 A ES 515766A ES 8403877 A1 ES8403877 A1 ES 8403877A1
- Authority
- ES
- Spain
- Prior art keywords
- mercapto
- imidazole derivatives
- preparation
- substituted
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE MERCAPTOIMIDAZOL, DE FORMULA GENERAL (I), EN LA QUE COMO MINIMO UNO DE LOS RESTOS R1 Y R2 SIGNIFICA UN GRUPO HETEROARILO Y EL OTRO SIGNIFICA ARILO; R3 SIGNIFICA HIDROGENO O ALQUILO INFERIOR; N ES 0, 1 O 2; Y R4 SIGNIFICA UN RESTO DE HIDROCARBURO ALIFATICO, Y SUS SALES DE ADICION DE ACIDO.CONSISTE EN HACER REACCIONAR ENTRE SI COMPUESTOS DE FORMULAS (II) Y (III), EN LAS QUE X E Y SIGNIFICAN MERCAPTO UNO DE ELLOS Y EL OTRO SIGNIFICA UN RESTO INTERCAMBIABLE POR MERCAPTO ETERADO; Y R1, R2, R3 Y R4 TIENEN LOS SIGNIFICADOSYA MENCIONADOS.DE APLICACION EN EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS, ESPECIALMENTE DE INFLAMACIONES CRONICAS DEL TIPO REUMATICO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU79412 | 1978-04-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8403877A1 true ES8403877A1 (es) | 1984-04-01 |
ES515766A0 ES515766A0 (es) | 1984-04-01 |
Family
ID=19728887
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES479490A Granted ES479490A0 (es) | 1978-04-11 | 1979-04-10 | Procedimiento para la obtencion de nuevos derivados de mer- captoimidazoles. |
ES515766A Granted ES515766A0 (es) | 1978-04-11 | 1982-09-16 | Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol. |
ES528579A Granted ES528579A0 (es) | 1978-04-11 | 1983-12-30 | Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol |
ES528580A Expired ES8504738A1 (es) | 1978-04-11 | 1983-12-30 | Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol |
ES528581A Granted ES528581A0 (es) | 1978-04-11 | 1983-12-30 | Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES479490A Granted ES479490A0 (es) | 1978-04-11 | 1979-04-10 | Procedimiento para la obtencion de nuevos derivados de mer- captoimidazoles. |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528579A Granted ES528579A0 (es) | 1978-04-11 | 1983-12-30 | Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol |
ES528580A Expired ES8504738A1 (es) | 1978-04-11 | 1983-12-30 | Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol |
ES528581A Granted ES528581A0 (es) | 1978-04-11 | 1983-12-30 | Procedimiento para la obtencion de nuevos derivados de mercaptoimidazol |
Country Status (24)
Country | Link |
---|---|
US (3) | US4461770A (es) |
EP (1) | EP0004648B1 (es) |
JP (1) | JPS54135769A (es) |
KR (2) | KR820002314B1 (es) |
AT (1) | AT376971B (es) |
AU (1) | AU532402B2 (es) |
CS (1) | CS220324B2 (es) |
CY (1) | CY1302A (es) |
DD (1) | DD142712A5 (es) |
DE (1) | DE2963572D1 (es) |
DK (1) | DK148879A (es) |
ES (5) | ES479490A0 (es) |
FI (1) | FI65066C (es) |
GR (1) | GR71193B (es) |
HK (1) | HK87285A (es) |
HU (1) | HU182018B (es) |
IL (1) | IL57040A (es) |
MY (1) | MY8600271A (es) |
NO (1) | NO148926C (es) |
NZ (1) | NZ190153A (es) |
PL (2) | PL125972B1 (es) |
PT (1) | PT69460A (es) |
SU (2) | SU1259962A3 (es) |
ZA (1) | ZA791702B (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2823197A1 (de) * | 1978-05-24 | 1979-11-29 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DE2856909A1 (de) * | 1978-12-28 | 1980-07-17 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DE3025484A1 (de) * | 1980-07-03 | 1982-02-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
US4686231A (en) * | 1985-12-12 | 1987-08-11 | Smithkline Beckman Corporation | Inhibition of 5-lipoxygenase products |
US4780470A (en) * | 1986-08-19 | 1988-10-25 | Smithkline Beckman Corporation | Inhibition of interleukin-1 by monocytes and/or macrophages |
FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
US5955480A (en) * | 1996-11-20 | 1999-09-21 | Merck & Co., Inc. | Triaryl substituted imidazoles, compositions containing such compounds and methods of use |
UA65572C2 (en) * | 1997-04-24 | 2004-04-15 | Ortho Mcneil Pharm Inc | Substituted imidazoles, intermediate compounds for the preparation thereof, a method for the preparation of substituted imidazoles and a method for the treatment of inflammatory diseases |
US6040320A (en) * | 1997-06-30 | 2000-03-21 | Ortho-Mcneil Pharmaceutical, Inc. | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
DE19842833B4 (de) * | 1998-09-18 | 2005-04-14 | Merckle Gmbh | 2-Arylalkylthio-imidazole, 2-Arylalkenylthio-imidazole und 2-Arylalkinylthio-imidazole als Entzündungs-Hemmstoffe und Hemmstoffe der Cytokin-Freisetzung |
DE10107683A1 (de) * | 2001-02-19 | 2002-08-29 | Merckle Gmbh Chem Pharm Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
DE10238045A1 (de) * | 2002-08-20 | 2004-03-04 | Merckle Gmbh Chem.-Pharm. Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
US8134029B2 (en) | 2002-09-16 | 2012-03-13 | Sunovion Pharmaceuticals Inc. | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine |
EP1904066B1 (en) | 2005-07-06 | 2018-05-23 | Sunovion Pharmaceuticals Inc. | COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, for treating MENOPAUSE, perimenopause AND COGNITIVE DISORDERS |
AU2007233041B2 (en) * | 2006-03-31 | 2013-05-02 | Sepracor Inc. | Preparation of chiral amides and amines |
EP1894925A1 (en) * | 2006-08-24 | 2008-03-05 | Merckle Gmbh | Imidazole compounds having an antiinflammatory effect |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2981739A (en) * | 1958-01-27 | 1961-04-25 | Diamond Alkali Co | Certain alpha-haloaldehyde addition products of ethylenethioureas and process |
US3714179A (en) * | 1970-09-08 | 1973-01-30 | Searle & Co | 1-alkyl-2-furfurylthioimidazoles and congeners |
JPS5343958B2 (es) * | 1972-07-29 | 1978-11-24 | ||
SE428686B (sv) * | 1975-08-11 | 1983-07-18 | Du Pont | Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler |
US4159338A (en) * | 1977-02-09 | 1979-06-26 | E. I. Du Pont De Nemours And Company | Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones |
DK16778A (da) * | 1977-02-09 | 1978-08-10 | Du Pont | Imidazolderivater deres anvendelser og fremstilling |
LU77703A1 (de) * | 1977-07-07 | 1979-03-26 | Ciba Geigy Ag | Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen |
DE2823197A1 (de) * | 1978-05-24 | 1979-11-29 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
US4308277A (en) * | 1978-08-10 | 1981-12-29 | Ciba-Geigy Corporation | 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same |
US4175127A (en) * | 1978-09-27 | 1979-11-20 | Smithkline Corporation | Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles |
DE2856909A1 (de) * | 1978-12-28 | 1980-07-17 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
-
1979
- 1979-03-30 EP EP79100962A patent/EP0004648B1/de not_active Expired
- 1979-03-30 DE DE7979100962T patent/DE2963572D1/de not_active Expired
- 1979-03-30 CY CY1302A patent/CY1302A/xx unknown
- 1979-04-06 GR GR58824A patent/GR71193B/el unknown
- 1979-04-06 PL PL1979214745A patent/PL125972B1/pl unknown
- 1979-04-06 PL PL1979226123A patent/PL125882B1/pl unknown
- 1979-04-09 DD DD79212098A patent/DD142712A5/de unknown
- 1979-04-09 FI FI791158A patent/FI65066C/fi not_active IP Right Cessation
- 1979-04-10 KR KR7901118A patent/KR820002314B1/ko active
- 1979-04-10 PT PT69460A patent/PT69460A/pt unknown
- 1979-04-10 ZA ZA791702A patent/ZA791702B/xx unknown
- 1979-04-10 DK DK148879A patent/DK148879A/da not_active IP Right Cessation
- 1979-04-10 SU SU2747651A patent/SU1259962A3/ru active
- 1979-04-10 AU AU45994/79A patent/AU532402B2/en not_active Ceased
- 1979-04-10 IL IL57040A patent/IL57040A/xx unknown
- 1979-04-10 HU HU79CI1925A patent/HU182018B/hu unknown
- 1979-04-10 NZ NZ190153A patent/NZ190153A/en unknown
- 1979-04-10 NO NO791228A patent/NO148926C/no unknown
- 1979-04-10 AT AT0266179A patent/AT376971B/de not_active IP Right Cessation
- 1979-04-10 CS CS792438A patent/CS220324B2/cs unknown
- 1979-04-10 ES ES479490A patent/ES479490A0/es active Granted
- 1979-04-11 JP JP4311779A patent/JPS54135769A/ja active Granted
-
1980
- 1980-05-23 SU SU802925099A patent/SU991945A3/ru active
-
1981
- 1981-11-16 US US06/321,840 patent/US4461770A/en not_active Expired - Fee Related
-
1982
- 1982-09-16 ES ES515766A patent/ES515766A0/es active Granted
- 1982-10-04 KR KR8204468A patent/KR820002315B1/ko active
-
1983
- 1983-12-30 ES ES528579A patent/ES528579A0/es active Granted
- 1983-12-30 ES ES528580A patent/ES8504738A1/es not_active Expired
- 1983-12-30 ES ES528581A patent/ES528581A0/es active Granted
-
1984
- 1984-03-09 US US06/588,024 patent/US4584310A/en not_active Expired - Fee Related
- 1984-03-09 US US06/588,025 patent/US4608382A/en not_active Expired - Fee Related
-
1985
- 1985-11-07 HK HK872/85A patent/HK87285A/xx unknown
-
1986
- 1986-12-30 MY MY271/86A patent/MY8600271A/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19991108 |