ES473451A1 - Un procedimiento para la preparacion de derivados de imida- zol. - Google Patents
Un procedimiento para la preparacion de derivados de imida- zol.Info
- Publication number
- ES473451A1 ES473451A1 ES473451A ES473451A ES473451A1 ES 473451 A1 ES473451 A1 ES 473451A1 ES 473451 A ES473451 A ES 473451A ES 473451 A ES473451 A ES 473451A ES 473451 A1 ES473451 A1 ES 473451A1
- Authority
- ES
- Spain
- Prior art keywords
- imidazole derivatives
- synthesis
- pharmaceutical formulations
- formula
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un procedimiento para la preparación de derivados de imidazol de la fórmula general **(Fórmula)** en donde R1, R2, R3 y R4 denotan, cada uno, hidrógeno o R1 junto con R2 y R3 junto con R4 denotan, cada uno, un enlace carbono carbono adicional, N es el número 0 ó 1, R5 denota hidrógeno o alquilo inferior y X denota un radical 2-piridílico opcionalmente mono-substituido por alquilo inferior, un radical 2-imidazolílico, un radical 2-imidazolinílico, un radical 2-tiazolílico, un radical 2-tiazolinílico o un radical 4(5)-imidazolílico opcionalmente mono-substituido por alquilo inferior.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU78140 | 1977-09-19 | ||
CH814978 | 1978-07-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES473451A1 true ES473451A1 (es) | 1979-05-01 |
Family
ID=25702876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES473451A Expired ES473451A1 (es) | 1977-09-19 | 1978-09-18 | Un procedimiento para la preparacion de derivados de imida- zol. |
Country Status (36)
Country | Link |
---|---|
US (2) | US4182766A (es) |
EP (1) | EP0001279B1 (es) |
JP (1) | JPS5459274A (es) |
AR (1) | AR224350A1 (es) |
AT (1) | AT368152B (es) |
AU (1) | AU519711B2 (es) |
BG (1) | BG28708A3 (es) |
BR (1) | BR7806148A (es) |
CA (1) | CA1106849A (es) |
DD (1) | DD138210A5 (es) |
DE (2) | DE2861237D1 (es) |
DK (1) | DK406578A (es) |
EG (1) | EG13530A (es) |
ES (1) | ES473451A1 (es) |
FI (1) | FI64365C (es) |
FR (1) | FR2403340A1 (es) |
GB (1) | GB2004281B (es) |
GR (1) | GR73069B (es) |
HU (1) | HU176111B (es) |
IE (1) | IE47363B1 (es) |
IL (1) | IL55557A (es) |
IN (1) | IN148930B (es) |
IT (1) | IT1098858B (es) |
MC (1) | MC1213A1 (es) |
MT (1) | MTP835B (es) |
NL (1) | NL7809529A (es) |
NO (1) | NO149962C (es) |
NZ (1) | NZ188405A (es) |
OA (1) | OA06054A (es) |
PH (1) | PH16342A (es) |
PL (1) | PL114494B1 (es) |
PT (1) | PT68573A (es) |
RO (1) | RO75258A (es) |
SE (1) | SE7809792L (es) |
SU (1) | SU793390A3 (es) |
YU (1) | YU216778A (es) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4321372A (en) * | 1980-06-16 | 1982-03-23 | Pfizer Inc. | Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides |
US4359465A (en) * | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
CH644116A5 (de) | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
US4368201A (en) * | 1981-07-20 | 1983-01-11 | Usv Pharmaceutical Corporation | Tetrahydronaphthoxazoles |
ZA825106B (en) * | 1981-08-13 | 1983-04-27 | Haessle Ab | Novel pharmaceutical compositions |
HU191757B (en) * | 1983-05-03 | 1987-04-28 | Byk Gulden Lomberg Chem Fab | Process for producing new tricyclic ethers |
ZW4585A1 (en) * | 1984-04-19 | 1985-11-20 | Hoffmann La Roche | Imidazole derivatives |
GB2161160B (en) * | 1984-07-06 | 1989-05-24 | Fisons Plc | Heterocyclic sulphinyl compounds |
DE3585252D1 (de) * | 1984-07-06 | 1992-03-05 | Fisons Plc | Benzimidazole, und verfahren zu deren herstellung, deren formulierung und verwendung als magensaeuresekretionshemmende verbindungen. |
SE8404065D0 (sv) * | 1984-08-10 | 1984-08-10 | Haessle Ab | Novel biologically active compounds |
DE3501497A1 (de) * | 1985-01-18 | 1986-07-24 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte |
US5869513A (en) * | 1985-05-24 | 1999-02-09 | G. D. Searle & Co. | 2- (1H-benzimidazol-2-ylsulfinyl)methyl!benzenamines |
AU5768886A (en) | 1985-05-24 | 1986-11-27 | G.D. Searle & Co. | 2-((1-h-benzimidazol-2-ylsulfinyl)methyl)benzenamines |
DK337086A (da) * | 1985-08-12 | 1987-02-13 | Hoffmann La Roche | Benzimidazolderivater |
SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
SE8600658D0 (sv) * | 1986-02-14 | 1986-02-14 | Haessle Ab | Novel composition of matter |
US4772619A (en) * | 1986-07-17 | 1988-09-20 | G. D. Searle & Co. | [(1H-benzimidazol-2-ylsulfinyl)methyl]-2-pyridinamines |
US4687775A (en) * | 1986-07-17 | 1987-08-18 | G. D. Searle & Co. | 2-[(Imidazo[1,2-a]pyridinylmethyl)sulfinyl]-1H-benzimidazoles |
US4721718A (en) * | 1986-08-18 | 1988-01-26 | G. D. Searle & Co. | 2-[(imidazo[1,2-a]pyridin-3-ylmethyl)sulfinyl]-1H-benzimidazoles useful in the treatment and prevention of ulcers |
SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
SE8604998D0 (sv) | 1986-11-21 | 1986-11-21 | Haessle Ab | Novel pharmacological compounds |
NZ222495A (en) | 1986-11-21 | 1991-04-26 | Haessle Ab | Benzimidazole derivatives and pharmaceutical compositions |
FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
DE3701277A1 (de) * | 1987-01-17 | 1988-07-28 | Boehringer Mannheim Gmbh | Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel |
US4931557A (en) * | 1988-10-17 | 1990-06-05 | Eli Lilly And Company | Method of resolving cis 3-amino-4-(2-furyl)vinyl)-1-methoxycarbonylmethyl-azetidin-2-one and di-p-toluoyl-tartaric acid salts thereof |
SE8804629D0 (sv) | 1988-12-22 | 1988-12-22 | Ab Haessle | New therapeutically active compounds |
SE8804628D0 (sv) | 1988-12-22 | 1988-12-22 | Ab Haessle | New compounds |
IE64199B1 (en) * | 1988-12-22 | 1995-07-12 | Haessle Ab | Compound with gastric acid inhibitory effect and process for its preparation |
US5049674A (en) | 1989-12-20 | 1991-09-17 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
US5274099A (en) * | 1989-12-20 | 1993-12-28 | Aktiebolaget Hassle | Therapeutically active fluoro substituted benzimidazoles |
US4965269A (en) * | 1989-12-20 | 1990-10-23 | Ab Hassle | Therapeutically active chloro substituted benzimidazoles |
SE9002043D0 (sv) * | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
SE9002206D0 (sv) | 1990-06-20 | 1990-06-20 | Haessle Ab | New compounds |
WO1994001107A1 (en) * | 1992-07-08 | 1994-01-20 | Monsanto Company | Benzimidazoles for alleviating stomach ulcers in swine |
WO1995029897A1 (en) * | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS |
NZ318501A (en) * | 1995-09-21 | 1999-06-29 | Pharma Pass Llc | Novel composition containing an acid-labile omeprazole and process for its preparation |
US6645988B2 (en) * | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
KR100463031B1 (ko) * | 1997-05-26 | 2005-04-06 | 동아제약주식회사 | 5-메톡시-2-[3,5-디메틸-4-메톡시피리딜메틸)설피닐]-1h-벤즈이미다졸의신규제조방법 |
US6174548B1 (en) | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6096340A (en) * | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
US6733778B1 (en) | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
JP2005521662A (ja) * | 2002-01-25 | 2005-07-21 | サンタラス インコーポレイティッド | プロトンポンプ阻害剤の経粘膜送達 |
JP2006518751A (ja) * | 2003-02-20 | 2006-08-17 | サンタラス インコーポレイティッド | 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物 |
US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
CA2531564C (en) * | 2003-07-18 | 2016-01-19 | Santarus, Inc. | Pharmaceutical composition for inhibiting acid secretion |
US20050031700A1 (en) * | 2003-07-18 | 2005-02-10 | Sanatarus, Inc. | Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders |
US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US20060024362A1 (en) * | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
WO2008067037A2 (en) | 2006-10-05 | 2008-06-05 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
EP2086543A2 (en) | 2006-10-27 | 2009-08-12 | The Curators of the University of Missouri | Compositions comprising at least one acid labile proton pump inhibiting agents, optionally other pharmaceutically active agents and methods of using same |
WO2024075017A1 (en) | 2022-10-04 | 2024-04-11 | Zabirnyk Arsenii | Inhibition of aortic valve calcification |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2985661A (en) * | 1956-02-06 | 1961-05-23 | American Cyanamid Co | Preparation of 2(omicron-aminophenyl)-benzimidazole |
GB1234058A (es) * | 1968-10-21 | 1971-06-03 | ||
SE418966B (sv) * | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
SE416649B (sv) * | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
-
1978
- 1978-08-30 IN IN949/CAL/78A patent/IN148930B/en unknown
- 1978-08-31 MC MC781323A patent/MC1213A1/xx unknown
- 1978-09-11 US US05/941,343 patent/US4182766A/en not_active Expired - Lifetime
- 1978-09-12 IL IL55557A patent/IL55557A/xx unknown
- 1978-09-13 EG EG554/78A patent/EG13530A/xx active
- 1978-09-13 NZ NZ188405A patent/NZ188405A/xx unknown
- 1978-09-13 AU AU39817/78A patent/AU519711B2/en not_active Expired
- 1978-09-13 BG BG7840865A patent/BG28708A3/xx unknown
- 1978-09-13 CA CA311,181A patent/CA1106849A/en not_active Expired
- 1978-09-14 DK DK406578A patent/DK406578A/da not_active Application Discontinuation
- 1978-09-14 PH PH21603A patent/PH16342A/en unknown
- 1978-09-14 OA OA56607A patent/OA06054A/xx unknown
- 1978-09-14 FR FR7826420A patent/FR2403340A1/fr active Granted
- 1978-09-14 YU YU02167/78A patent/YU216778A/xx unknown
- 1978-09-15 DD DD78207858A patent/DD138210A5/xx unknown
- 1978-09-18 NO NO783155A patent/NO149962C/no unknown
- 1978-09-18 JP JP11371578A patent/JPS5459274A/ja active Pending
- 1978-09-18 MT MT835A patent/MTP835B/xx unknown
- 1978-09-18 FI FI782847A patent/FI64365C/fi not_active IP Right Cessation
- 1978-09-18 HU HU78HO2102A patent/HU176111B/hu unknown
- 1978-09-18 IE IE1878/78A patent/IE47363B1/en unknown
- 1978-09-18 PT PT68573A patent/PT68573A/pt unknown
- 1978-09-18 ES ES473451A patent/ES473451A1/es not_active Expired
- 1978-09-18 GR GR57249A patent/GR73069B/el unknown
- 1978-09-18 DE DE7878100923T patent/DE2861237D1/de not_active Expired
- 1978-09-18 SE SE7809792A patent/SE7809792L/xx unknown
- 1978-09-18 AT AT0673378A patent/AT368152B/de not_active IP Right Cessation
- 1978-09-18 EP EP78100923A patent/EP0001279B1/de not_active Expired
- 1978-09-18 GB GB7837156A patent/GB2004281B/en not_active Expired
- 1978-09-18 DE DE19782840591 patent/DE2840591A1/de not_active Withdrawn
- 1978-09-18 SU SU782664651A patent/SU793390A3/ru active
- 1978-09-19 PL PL1978209693A patent/PL114494B1/pl unknown
- 1978-09-19 NL NL7809529A patent/NL7809529A/xx not_active Application Discontinuation
- 1978-09-19 IT IT27861/78A patent/IT1098858B/it active
- 1978-09-19 BR BR7806148A patent/BR7806148A/pt unknown
- 1978-09-19 AR AR273765A patent/AR224350A1/es active
- 1978-09-19 RO RO7895228A patent/RO75258A/ro unknown
-
1979
- 1979-07-02 US US06/054,210 patent/US4248880A/en not_active Expired - Lifetime
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19850207 |