ES8801633A1 - Procedimiento para preparar nuevos derivados de 3-piridil-metilnaftilo - Google Patents

Procedimiento para preparar nuevos derivados de 3-piridil-metilnaftilo

Info

Publication number
ES8801633A1
ES8801633A1 ES557647A ES557647A ES8801633A1 ES 8801633 A1 ES8801633 A1 ES 8801633A1 ES 557647 A ES557647 A ES 557647A ES 557647 A ES557647 A ES 557647A ES 8801633 A1 ES8801633 A1 ES 8801633A1
Authority
ES
Spain
Prior art keywords
medicaments
preparation
pyridylmethylnaphthyl
derivatives
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557647A
Other languages
English (en)
Other versions
ES557647A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES557647A0 publication Critical patent/ES557647A0/es
Publication of ES8801633A1 publication Critical patent/ES8801633A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE 3-PIRIDIL-METILNAFTILO, DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN SOMETER A METALACION SELECTIVAMENTE EN POSICION 2 UN COMPUESTO DE FORMULA GENERAL (II) Y A CONTINUACION SE HACE REACCIONAR CON UN COMPUESTO DE FORMULA GENERAL (III). EL COMPUESTO OBTENIDO SE OXIDA PARA OBTENER UN COMPUESTO DE FORMULA GENERAL (I). DE APLICACION EN HEMOSTASIS, EN SITUACIONES PATOLOGICAS CON TENDENCIA ACRECENTADA A ESPASMOS VASCULARES O TROMBOSIS.
ES557647A 1985-03-13 1987-07-31 Procedimiento para preparar nuevos derivados de 3-piridil-metilnaftilo Expired ES8801633A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853508903 DE3508903A1 (de) 1985-03-13 1985-03-13 Neue 3-pyridylmethylnaphtylderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
ES557647A0 ES557647A0 (es) 1988-02-16
ES8801633A1 true ES8801633A1 (es) 1988-02-16

Family

ID=6265029

Family Applications (2)

Application Number Title Priority Date Filing Date
ES552871A Expired ES8800156A1 (es) 1985-03-13 1986-03-11 Procedimiento para preparar nuevos derivados 3-piridilmetilnaftilicos
ES557647A Expired ES8801633A1 (es) 1985-03-13 1987-07-31 Procedimiento para preparar nuevos derivados de 3-piridil-metilnaftilo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES552871A Expired ES8800156A1 (es) 1985-03-13 1986-03-11 Procedimiento para preparar nuevos derivados 3-piridilmetilnaftilicos

Country Status (9)

Country Link
US (1) US4734406A (es)
EP (1) EP0194579B1 (es)
JP (1) JPS61227568A (es)
AT (1) ATE62226T1 (es)
DE (2) DE3508903A1 (es)
DK (1) DK114286A (es)
ES (2) ES8800156A1 (es)
GR (1) GR860679B (es)
PT (1) PT82175B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO174506B (no) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
GB9027258D0 (en) * 1990-12-17 1991-02-06 Erba Carlo Spa Pyridyl derivatives of substituted bicyclic compounds and process for their preparation
WO1997017850A1 (en) * 1995-11-13 1997-05-22 Smithkline Beecham Corporation Hemoregulatory compounds
JP4546589B2 (ja) * 1998-04-23 2010-09-15 武田薬品工業株式会社 ナフタレン誘導体
ATE293102T1 (de) 1998-04-23 2005-04-15 Takeda Pharmaceutical Naphthalene derivate ,ihre herstellung und verwendung
SG144941A1 (en) * 2003-07-10 2008-08-28 Osi Pharm Inc Naphthylene derivatives as cytochrome p450 inhibitors
US7662844B2 (en) * 2004-07-12 2010-02-16 Osi Pharmaceuticals, Inc. Naphthylene derivatives as cytochrome P450 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR75101B (es) * 1980-10-23 1984-07-13 Pfizer
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
ES8800156A1 (es) 1987-11-01
ES552871A0 (es) 1987-11-01
ATE62226T1 (de) 1991-04-15
DK114286A (da) 1986-09-14
EP0194579A3 (en) 1987-09-30
EP0194579A2 (de) 1986-09-17
PT82175B (pt) 1988-07-29
EP0194579B1 (de) 1991-04-03
DK114286D0 (da) 1986-03-12
DE3508903A1 (de) 1986-09-18
PT82175A (de) 1986-04-01
JPS61227568A (ja) 1986-10-09
DE3678470D1 (de) 1991-05-08
GR860679B (en) 1986-07-14
US4734406A (en) 1988-03-29
ES557647A0 (es) 1988-02-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203