ATE293102T1 - Naphthalene derivate ,ihre herstellung und verwendung - Google Patents
Naphthalene derivate ,ihre herstellung und verwendungInfo
- Publication number
- ATE293102T1 ATE293102T1 AT99917102T AT99917102T ATE293102T1 AT E293102 T1 ATE293102 T1 AT E293102T1 AT 99917102 T AT99917102 T AT 99917102T AT 99917102 T AT99917102 T AT 99917102T AT E293102 T1 ATE293102 T1 AT E293102T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- substituted
- group
- hydrogen atom
- sub
- Prior art date
Links
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical class C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- IHOBBYHEOBWAPZ-UHFFFAOYSA-L steroid c Chemical compound [Na+].[Na+].C1CC2CC(OS([O-])(=O)=O)C(OS([O-])(=O)=O)CC2(C)C(CCC23C)C1C3CC(O1)C2C2(C)OC1OC2CC(C(C)C)=C(C)C IHOBBYHEOBWAPZ-UHFFFAOYSA-L 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Fats And Perfumes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11380198 | 1998-04-23 | ||
| PCT/JP1999/002143 WO1999054309A1 (en) | 1998-04-23 | 1999-04-22 | Naphthalene derivatives, their production and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE293102T1 true ATE293102T1 (de) | 2005-04-15 |
Family
ID=14621427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99917102T ATE293102T1 (de) | 1998-04-23 | 1999-04-22 | Naphthalene derivate ,ihre herstellung und verwendung |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6573289B1 (de) |
| EP (1) | EP1073640B1 (de) |
| AT (1) | ATE293102T1 (de) |
| AU (1) | AU3534699A (de) |
| CA (1) | CA2328973A1 (de) |
| DE (1) | DE69924717T2 (de) |
| WO (1) | WO1999054309A1 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070129282A1 (en) * | 1998-11-24 | 2007-06-07 | Ahlem Clarence N | Pharmaceutical treatments and compositions |
| MXPA01007099A (es) | 1999-01-13 | 2002-03-27 | Univ New York State Res Found | Metodo novedoso para disenar inhibidores de la proteina cinasa. |
| US6713632B1 (en) | 1999-06-22 | 2004-03-30 | Takeda Chemical Industries, Ltd. | Process for the preparation of imidazole derivatives |
| EP1832598A3 (de) * | 1999-09-30 | 2008-01-02 | Hollis-Eden Pharmaceuticals Inc. | Therapeutische Behandlung von androgenrezeptorbedingten Leiden |
| US6800778B1 (en) | 1999-10-22 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Process for producing optically active naphthalene derivative and optical resolver therefor |
| PE20010781A1 (es) * | 1999-10-22 | 2001-08-08 | Takeda Chemical Industries Ltd | Compuestos 1-(1h-imidazol-4-il)-1-(naftil-2-sustituido)etanol, su produccion y utilizacion |
| CA2388508A1 (en) * | 1999-10-22 | 2001-05-03 | Takeda Chemical Industries, Ltd. | 1-substituted phenyl-1-(1h-imidazol-4-yl) alcohols, process for producing the same and use thereof |
| US7141598B2 (en) | 2000-11-17 | 2006-11-28 | Takeda Pharmaceutical Company, Ltd. | Imidazole derivatives, production method thereof and use thereof |
| WO2002040470A1 (en) * | 2000-11-20 | 2002-05-23 | Takeda Chemical Industries, Ltd. | Imidazole derivatives, process for their preparation and their use |
| WO2002046186A1 (en) * | 2000-12-08 | 2002-06-13 | Takeda Chemical Industries, Ltd. | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
| JP2003137814A (ja) * | 2001-08-10 | 2003-05-14 | Takeda Chem Ind Ltd | ＧｎＲＨアゴニストの併用剤 |
| US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
| US7129225B2 (en) * | 2001-10-22 | 2006-10-31 | The Research Foundation Of State University Of New York | Protection against and treatment of hearing loss |
| RU2363696C2 (ru) * | 2003-07-10 | 2009-08-10 | Оси Фармасьютикалз, Инк. | Производные нафтилена как ингибиторы цитохрома р450 |
| EP1711495A2 (de) | 2004-01-23 | 2006-10-18 | Amgen Inc. | Chinolin-, chinazolin-, pyridin- und pyrimidinverbindungen und deren verwendung bei der behandlung von entzündungen, angiogenese und krebs |
| EP1713484A2 (de) * | 2004-01-23 | 2006-10-25 | Amgen Inc. | Verbindungen und anwendungsverfahren |
| US7662844B2 (en) | 2004-07-12 | 2010-02-16 | Osi Pharmaceuticals, Inc. | Naphthylene derivatives as cytochrome P450 inhibitors |
| MX2007006230A (es) * | 2004-11-30 | 2007-07-25 | Amgen Inc | Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer. |
| JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
| ES2338716T3 (es) * | 2006-01-27 | 2010-05-11 | F.Hoffmann-La Roche Ag | Uso de derivados de 4-imidazol para trastornos del snc. |
| US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| CN101528709B (zh) * | 2006-10-19 | 2012-02-01 | 弗·哈夫曼-拉罗切有限公司 | 对痕量胺相关受体有亲和性的氨基甲基-2-咪唑类 |
| CA2666762C (en) * | 2006-10-19 | 2014-12-30 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
| JP5064511B2 (ja) | 2006-11-02 | 2012-10-31 | エフ．ホフマン−ラ ロシュ アーゲー | 痕跡アミン関連受容体調節剤としての置換２−イミダゾール |
| RU2456281C2 (ru) * | 2006-11-16 | 2012-07-20 | Ф. Хоффманн-Ля Рош Аг | Замещенные 4-имидазолы, способ их получения и их применение |
| ATE509628T1 (de) * | 2006-12-13 | 2011-06-15 | Hoffmann La Roche | Neue 2-imidazole als liganden für trace amine associated receptors (taar) |
| US20080146523A1 (en) * | 2006-12-18 | 2008-06-19 | Guido Galley | Imidazole derivatives |
| JP5248528B2 (ja) | 2007-02-02 | 2013-07-31 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｎｓ疾患用のｔａａｒ１リガンドとしての新規２−アミノオキサゾリン |
| MX2009008465A (es) * | 2007-02-15 | 2009-08-20 | Hoffmann La Roche | Nuevas 2-aminooxazolinas como ligandos de taar1. |
| JP2010531837A (ja) | 2007-07-02 | 2010-09-30 | エフ．ホフマン−ラ ロシュ アーゲー | 微量アミン関連レセプター（ｔａａｒ）に対して良好な親和性を有する２−イミダゾリン |
| CA2691704A1 (en) * | 2007-07-03 | 2009-01-08 | F. Hoffmann-La Roche Ag | 4-imidazolines and their use as antidepressants |
| KR101133862B1 (ko) * | 2007-07-27 | 2012-04-06 | 에프. 호프만-라 로슈 아게 | Ｔａａｒ 리간드로서의 2-아제티딘메테인아민 및 2-피롤리딘메테인아민 |
| EP2182935A1 (de) * | 2007-08-02 | 2010-05-12 | F. Hoffmann-Roche AG | Verwendung von benzamid-derivaten zur behandlung von leiden des zentralen nervensystems |
| AU2008285795A1 (en) * | 2007-08-03 | 2009-02-12 | F. Hoffmann-La Roche Ag | Pyridinecarboxamide and benzamide derivatives as TAAR1 ligands |
| CA2703257C (en) * | 2007-10-29 | 2013-02-19 | Amgen Inc. | Benzomorpholine derivatives and methods of use |
| AU2009273324A1 (en) * | 2008-07-24 | 2010-01-28 | F. Hoffmann-La Roche Ag | 4,5-dihydro-oxazol-2-yl derivatives |
| US8242153B2 (en) * | 2008-07-24 | 2012-08-14 | Hoffmann-La Roche Inc. | 4,5-dihydro-oxazol-2YL derivatives |
| US20100311798A1 (en) * | 2009-06-05 | 2010-12-09 | Decoret Guillaume | 2-aminooxazolines as taar1 ligands |
| JP5456891B2 (ja) | 2009-06-26 | 2014-04-02 | ノバルティス アーゲー | Ｃｙｐ１７阻害剤としての１，３−二置換イミダゾリジン−２−オン誘導体 |
| US8354441B2 (en) * | 2009-11-11 | 2013-01-15 | Hoffmann-La Roche Inc. | Oxazoline derivatives |
| US9452980B2 (en) | 2009-12-22 | 2016-09-27 | Hoffmann-La Roche Inc. | Substituted benzamides |
| EP2521545B1 (de) | 2010-01-07 | 2019-11-27 | Alkermes Pharma Ireland Limited | Prodrugs aus heteroaromatischen verbindungen |
| AU2011285724B2 (en) | 2010-08-04 | 2015-01-22 | Pellficure Pharmaceuticals, Inc. | Combination therapy for the treatment of prostate carcinoma |
| CN103108871B (zh) | 2010-09-16 | 2014-09-10 | 诺华股份有限公司 | 17α-羟化酶/C17,20-裂合酶抑制剂 |
| CN103339115B (zh) * | 2010-11-13 | 2016-08-31 | 茵库恩制药有限公司 | 金属酶抑制剂化合物 |
| AU2012249421B9 (en) | 2011-04-28 | 2015-10-22 | Novartis Ag | 17alpha-hydroxylase/C17,20-lyase inhibitors |
| EP2751117A4 (de) * | 2011-08-30 | 2015-06-24 | Innocrin Pharmaceuticals Inc | Metalloenzymhemmerverbindungen |
| EP2968219B1 (de) | 2013-03-14 | 2019-04-24 | Pellficure Pharmaceuticals, Inc. | Neuartige therapie gegen prostatakarzinome |
| CA2960750A1 (en) | 2014-09-12 | 2016-03-17 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
| PE20181446A1 (es) | 2016-03-17 | 2018-09-12 | Hoffmann La Roche | Derivados de 5-etil-4-metil-pirazol-3-carboxamida con actividad como de taar |
| AU2017350690A1 (en) | 2016-10-24 | 2019-06-13 | Pellficure Pharmaceuticals Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione |
| CN114213296B (zh) * | 2021-12-23 | 2024-01-26 | 中节能万润股份有限公司 | 含异硫氰基的萘系列液晶单体化合物以及制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1154722A (en) * | 1965-07-08 | 1969-06-11 | Boots Pure Drug Co Ltd | 2,4,5-Tribromoimidazole Derivatives and Compositions thereof |
| US3759934A (en) * | 1970-12-09 | 1973-09-18 | Sandoz Ag | 2,3 or 4-pyri dinemethanol-alpha-substituted or unsubstituted phenyls-alpha-(2 or 3-alkoxy-1-naphthyls) |
| EP0098690B1 (de) * | 1982-06-14 | 1987-09-09 | Takeda Chemical Industries, Ltd. | Vinylcarbonsäure-Derivate, ihre Herstellung und Verwendung |
| DE3508903A1 (de) | 1985-03-13 | 1986-09-18 | Hoechst Ag, 6230 Frankfurt | Neue 3-pyridylmethylnaphtylderivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| EP0273647B1 (de) * | 1986-12-27 | 1992-03-11 | Takeda Chemical Industries, Ltd. | 2,3-Dihydro-Cumaron-Derivate, ihre Herstellung und Verwendung |
| FR2617478B1 (fr) * | 1987-07-01 | 1990-01-05 | Esteve Labor Dr | Nouveaux derives d'aryl-heteroaryl cetones, leur procede de preparation ainsi que leur application a titre de medicament |
| WO1992016527A1 (fr) | 1991-03-22 | 1992-10-01 | Nippon Soda Co., Ltd. | Derive de pyridine substitue en position 2, sa production, et bactericide d'agrohorticulture |
| ZA944647B (en) * | 1993-07-06 | 1995-01-06 | Astra Ab | Novel (1-phenyl-1-heterocyclyl)methanol and (1-phenyl-1-heterocyclcl)methylamine derivatives |
| SE9302333D0 (sv) * | 1993-07-06 | 1993-07-06 | Ab Astra | New compounds |
| AU679119B2 (en) | 1993-09-30 | 1997-06-19 | Yamanouchi Pharmaceutical Co., Ltd. | Azole derivative and pharmaceutical composition thereof |
| HUP9801158A3 (en) * | 1995-03-01 | 1999-11-29 | Yamanouchi Pharma Co Ltd | Imidazole derivatives and medicinal composition thereof |
| AU710875B2 (en) | 1995-12-06 | 1999-09-30 | Tokuyama Corporation | Chromene compounds and photochromic materials |
| US6713632B1 (en) * | 1999-06-22 | 2004-03-30 | Takeda Chemical Industries, Ltd. | Process for the preparation of imidazole derivatives |
| EP1192600B1 (de) * | 1999-07-06 | 2003-01-02 | GSI Gesellschaft für Systemtechnik und Informatik mbH | Vorrichtung zur flexiblen gebührenerfassung |
| US6800778B1 (en) | 1999-10-22 | 2004-10-05 | Takeda Chemical Industries, Ltd. | Process for producing optically active naphthalene derivative and optical resolver therefor |
-
1999
- 1999-04-22 AT AT99917102T patent/ATE293102T1/de not_active IP Right Cessation
- 1999-04-22 AU AU35346/99A patent/AU3534699A/en not_active Abandoned
- 1999-04-22 WO PCT/JP1999/002143 patent/WO1999054309A1/en not_active Ceased
- 1999-04-22 CA CA002328973A patent/CA2328973A1/en not_active Abandoned
- 1999-04-22 US US09/673,591 patent/US6573289B1/en not_active Expired - Lifetime
- 1999-04-22 DE DE69924717T patent/DE69924717T2/de not_active Expired - Lifetime
- 1999-04-22 EP EP99917102A patent/EP1073640B1/de not_active Expired - Lifetime
-
2003
- 2003-05-22 US US10/443,379 patent/US7084149B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1073640B1 (de) | 2005-04-13 |
| AU3534699A (en) | 1999-11-08 |
| CA2328973A1 (en) | 1999-10-28 |
| EP1073640A1 (de) | 2001-02-07 |
| DE69924717T2 (de) | 2006-03-09 |
| WO1999054309A1 (en) | 1999-10-28 |
| US6573289B1 (en) | 2003-06-03 |
| US7084149B2 (en) | 2006-08-01 |
| DE69924717D1 (de) | 2005-05-19 |
| US20030236274A1 (en) | 2003-12-25 |
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