DE69911935D1 - Granulatimide-derivate zur behandlung von krebs - Google Patents

Granulatimide-derivate zur behandlung von krebs

Info

Publication number
DE69911935D1
DE69911935D1 DE69911935T DE69911935T DE69911935D1 DE 69911935 D1 DE69911935 D1 DE 69911935D1 DE 69911935 T DE69911935 T DE 69911935T DE 69911935 T DE69911935 T DE 69911935T DE 69911935 D1 DE69911935 D1 DE 69911935D1
Authority
DE
Germany
Prior art keywords
granulatimide
derivatives
treating cancer
iii
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69911935T
Other languages
English (en)
Other versions
DE69911935T2 (de
DE69911935T3 (de
Inventor
J Andersen
Michel Roberge
Jasbinder Sanghera
Danny Leung
Roberto G S Berlinck
Edward Piers
Robert Britton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of British Columbia
Original Assignee
University of British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27170646&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69911935(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CA 2232074 external-priority patent/CA2232074A1/en
Priority claimed from CA002245029A external-priority patent/CA2245029A1/en
Application filed by University of British Columbia filed Critical University of British Columbia
Publication of DE69911935D1 publication Critical patent/DE69911935D1/de
Publication of DE69911935T2 publication Critical patent/DE69911935T2/de
Application granted granted Critical
Publication of DE69911935T3 publication Critical patent/DE69911935T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
DE69911935T 1998-03-13 1999-03-11 Granulatimide-derivate zur behandlung von krebs Expired - Lifetime DE69911935T3 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CA 2232074 CA2232074A1 (en) 1998-03-13 1998-03-13 Granulatimide compounds as g2 checkpoint inhibitors
CA2232074 1998-03-13
CA2245029 1998-08-14
CA002245029A CA2245029A1 (en) 1998-03-13 1998-08-14 Granulatimide compounds as g2 checkpoint inhibitors
US258991 1999-02-26
US09/258,991 US6291447B1 (en) 1998-03-13 1999-02-26 Granulatimide compounds and uses thereof
PCT/CA1999/000224 WO1999047522A1 (en) 1998-03-13 1999-03-11 Granulatimide derivatives for use in cancer treatment

Publications (3)

Publication Number Publication Date
DE69911935D1 true DE69911935D1 (de) 2003-11-13
DE69911935T2 DE69911935T2 (de) 2004-09-09
DE69911935T3 DE69911935T3 (de) 2008-02-07

Family

ID=27170646

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69911935T Expired - Lifetime DE69911935T3 (de) 1998-03-13 1999-03-11 Granulatimide-derivate zur behandlung von krebs

Country Status (6)

Country Link
EP (1) EP1070068B2 (de)
JP (1) JP2002506868A (de)
AT (1) ATE251624T1 (de)
AU (1) AU758241B2 (de)
DE (1) DE69911935T3 (de)
WO (1) WO1999047522A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2288042T3 (es) 1998-09-25 2007-12-16 Cephalon, Inc. Uso de pirrolocarbazoles condensados para prevenir/tratar daños de las celulas ciliadas sensoriales y neuronas cocleares.
US6841567B1 (en) 1999-02-12 2005-01-11 Cephalon, Inc. Cyclic substituted fused pyrrolocarbazoles and isoindolones
JP2003518503A (ja) * 1999-12-23 2003-06-10 ザ オンタリオ キャンサー インスティテュート ＧＳＫ−３βの阻害
GB0008264D0 (en) * 2000-04-04 2000-05-24 Smithkline Beecham Plc Novel method and compounds
US7122679B2 (en) 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
AUPR500201A0 (en) 2001-05-14 2001-06-07 Commonwealth Scientific And Industrial Research Organisation Recovery of minerals by flotation
CA2487388C (en) * 2002-06-06 2011-05-10 Canbas Co., Ltd. Compounds that abrogate dna-damage-induced cell cycle g2 checkpoint and/or augment the anti-cancer activity of dna-damaging treatments
FR2845995A1 (fr) * 2002-10-16 2004-04-23 Servier Lab Nouveaux derives de pyrrolo[3,4-c]carbazole et de pyrido[2,3-b]pyrrolo[3,4-e]indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP2275095A3 (de) 2005-08-26 2011-08-17 Braincells, Inc. Neurogenese durch modulation des Muscarinrezeptors
EP2258357A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
EP2377530A3 (de) 2005-10-21 2012-06-20 Braincells, Inc. Modulation von Neurogenese durch PDE-Hemmung
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2382975A3 (de) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenese mittels Angiotensin-Modulation
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2009127059A1 (en) * 2008-04-15 2009-10-22 Alethia Biotherapeutics Inc. Complexes of isogranulatimide and granulatimide with a cyclodextrm, formulations and their use for the treatment of cancer
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN103864890B (zh) * 2012-12-12 2016-09-14 浙江医药股份有限公司新昌制药厂 咪唑异丙乙酰茶氨酸苄酯并吡啶并吲哚、其制备、纳米结构及应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3803620A1 (de) * 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
WO1991009034A1 (en) * 1989-12-14 1991-06-27 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
DE3942296A1 (de) * 1989-12-21 1991-06-27 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
KR950702994A (ko) * 1992-08-12 1995-08-23 로렌스 티. 웰츠 탁솔과 복합된, 단백질 키나제 억제제 및 관련 화합물(protein kinase inhibitors and related compounds combined with taxol)
WO1994007895A1 (en) * 1992-09-25 1994-04-14 Schering Corporation Diindolo compounds and pharmaceutical compositions containing them
KR100340159B1 (ko) * 1993-12-07 2002-11-23 일라이 릴리 앤드 캄파니 단백질키나제c억제제
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5604219A (en) * 1994-03-18 1997-02-18 Kyowa Hakko Kogyo Co., Ltd. Indolocarbazole derivatives that stimulate platelet production
WO1995032976A1 (en) * 1994-06-01 1995-12-07 Ciba-Geigy Ag Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents
JPH10501526A (ja) * 1994-06-01 1998-02-10 チバ−ガイギー アクチェンゲゼルシャフト 多薬物耐性に対する作用物質としてのカルバゾール誘導体
AU2565895A (en) * 1994-06-01 1995-12-21 Ciba-Geigy Ag Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
ATE172199T1 (de) * 1995-11-20 1998-10-15 Lilly Co Eli Proteinkinase-c-inhibitor
UA56145C2 (uk) * 1995-11-20 2003-05-15 Елі Ліллі Енд Компані Нові проміжні продукти для одержання n,n'-місткових бісіндолілмалеімідів, спосіб отримання цих проміжних продуктів та фармацевтична композиція на їх основі
FR2755691B1 (fr) * 1996-11-08 1998-12-04 Adir Nouveaux derives 7,12-dioxa-benzo[a]anthraceniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ATE251624T1 (de) 2003-10-15
DE69911935T2 (de) 2004-09-09
AU758241B2 (en) 2003-03-20
EP1070068A1 (de) 2001-01-24
DE69911935T3 (de) 2008-02-07
AU2821999A (en) 1999-10-11
JP2002506868A (ja) 2002-03-05
EP1070068B2 (de) 2007-01-17
EP1070068B1 (de) 2003-10-08
WO1999047522A1 (en) 1999-09-23

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings