ATE251624T1 - Granulatimide-derivate zur behandlung von krebs - Google Patents

Granulatimide-derivate zur behandlung von krebs

Info

Publication number
ATE251624T1
ATE251624T1 AT99908706T AT99908706T ATE251624T1 AT E251624 T1 ATE251624 T1 AT E251624T1 AT 99908706 T AT99908706 T AT 99908706T AT 99908706 T AT99908706 T AT 99908706T AT E251624 T1 ATE251624 T1 AT E251624T1
Authority
AT
Austria
Prior art keywords
granulatimide
cancer
derivatives
treatment
iii
Prior art date
Application number
AT99908706T
Other languages
English (en)
Inventor
Raymond J Andersen
Michel Roberge
Jasbinder Sanghera
Danny Leung
Roberto G S Berlinck
Sao Paulo De
Edward Piers
Robert Britton
Original Assignee
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27170646&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE251624(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CA 2232074 external-priority patent/CA2232074A1/en
Priority claimed from CA002245029A external-priority patent/CA2245029A1/en
Application filed by Univ British Columbia filed Critical Univ British Columbia
Application granted granted Critical
Publication of ATE251624T1 publication Critical patent/ATE251624T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
AT99908706T 1998-03-13 1999-03-11 Granulatimide-derivate zur behandlung von krebs ATE251624T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA 2232074 CA2232074A1 (en) 1998-03-13 1998-03-13 Granulatimide compounds as g2 checkpoint inhibitors
CA002245029A CA2245029A1 (en) 1998-03-13 1998-08-14 Granulatimide compounds as g2 checkpoint inhibitors
US09/258,991 US6291447B1 (en) 1998-03-13 1999-02-26 Granulatimide compounds and uses thereof
PCT/CA1999/000224 WO1999047522A1 (en) 1998-03-13 1999-03-11 Granulatimide derivatives for use in cancer treatment

Publications (1)

Publication Number Publication Date
ATE251624T1 true ATE251624T1 (de) 2003-10-15

Family

ID=27170646

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99908706T ATE251624T1 (de) 1998-03-13 1999-03-11 Granulatimide-derivate zur behandlung von krebs

Country Status (6)

Country Link
EP (1) EP1070068B2 (de)
JP (1) JP2002506868A (de)
AT (1) ATE251624T1 (de)
AU (1) AU758241B2 (de)
DE (1) DE69911935T3 (de)
WO (1) WO1999047522A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002525329A (ja) 1998-09-25 2002-08-13 セフアロン・インコーポレーテツド 感覚毛細胞及び蝸牛ニューロンへの損傷を予防する／処置するための方法
US6841567B1 (en) 1999-02-12 2005-01-11 Cephalon, Inc. Cyclic substituted fused pyrrolocarbazoles and isoindolones
WO2001047533A2 (en) * 1999-12-23 2001-07-05 The Ontario Cancer Institute INHIBITION OF GSK-3$g(b)
GB0008264D0 (en) * 2000-04-04 2000-05-24 Smithkline Beecham Plc Novel method and compounds
US7122679B2 (en) 2000-05-09 2006-10-17 Cephalon, Inc. Multicyclic compounds and the use thereof
CA2308994A1 (en) * 2000-05-19 2001-11-19 Aegera Therapeutics Inc. Neuroprotective compounds
US7129250B2 (en) 2000-05-19 2006-10-31 Aegera Therapeutics Inc. Neuroprotective and anti-proliferative compounds
AUPR500201A0 (en) 2001-05-14 2001-06-07 Commonwealth Scientific And Industrial Research Organisation Recovery of minerals by flotation
EP1511713B8 (de) 2002-06-06 2012-02-08 CanBas Co. Ltd. Verbindungen, die den durch dna-schädigung induzierten g2-checkpoint des zellzyklus stilllegen und/oder die antikrebswirkung von dna-schädigenden behandlungen erhöhen
FR2845995A1 (fr) * 2002-10-16 2004-04-23 Servier Lab Nouveaux derives de pyrrolo[3,4-c]carbazole et de pyrido[2,3-b]pyrrolo[3,4-e]indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1928437A2 (de) 2005-08-26 2008-06-11 Braincells, Inc. Neurogenese mittels muscarinrezeptormodulation
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
EP1940389A2 (de) 2005-10-21 2008-07-09 Braincells, Inc. Modulation von neurogenese durch pde-hemmung
EP2314289A1 (de) 2005-10-31 2011-04-27 Braincells, Inc. Gaba-rezeptor-vermittelte modulation von neurogenese
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2377531A2 (de) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenese mittels Angiotensin-Modulation
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2009127059A1 (en) * 2008-04-15 2009-10-22 Alethia Biotherapeutics Inc. Complexes of isogranulatimide and granulatimide with a cyclodextrm, formulations and their use for the treatment of cancer
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
CN103864890B (zh) * 2012-12-12 2016-09-14 浙江医药股份有限公司新昌制药厂 咪唑异丙乙酰茶氨酸苄酯并吡啶并吲哚、其制备、纳米结构及应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3803620A1 (de) * 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
AU7035991A (en) * 1989-12-14 1991-07-18 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
DE3942296A1 (de) * 1989-12-21 1991-06-27 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
KR950702994A (ko) * 1992-08-12 1995-08-23 로렌스 티. 웰츠 탁솔과 복합된, 단백질 키나제 억제제 및 관련 화합물(protein kinase inhibitors and related compounds combined with taxol)
AU5100393A (en) * 1992-09-25 1994-04-26 Schering Corporation Diindolo compounds and pharmaceutical compositions containing them
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
DE69428025T2 (de) * 1993-12-07 2002-05-29 Lilly Co Eli Proteinkinase C-Inhibitoren
US5604219A (en) * 1994-03-18 1997-02-18 Kyowa Hakko Kogyo Co., Ltd. Indolocarbazole derivatives that stimulate platelet production
WO1995032976A1 (en) * 1994-06-01 1995-12-07 Ciba-Geigy Ag Polycyclic lactam derivatives for sensitizing multidrug-resistant cells to antitumour agents
WO1995032974A1 (en) * 1994-06-01 1995-12-07 Ciba-Geigy Ag Carbazole derivatives as agents against multi-drug resistance
AU2565895A (en) * 1994-06-01 1995-12-21 Ciba-Geigy Ag Indolocarbazole derivatives for sensitizing multidrug-resistant cells to antitumor agents
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
NZ323571A (en) * 1995-11-20 1998-12-23 Lilly Co Eli Protein kinase c inhibitor
EA000639B1 (ru) * 1995-11-20 1999-12-29 Эли Лилли Энд Компани Новые промежуточные продукты и их использование для получения n,n'-мостиковых бисиндолилмалеимидов
FR2755691B1 (fr) * 1996-11-08 1998-12-04 Adir Nouveaux derives 7,12-dioxa-benzo[a]anthraceniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
WO1999047522A1 (en) 1999-09-23
EP1070068B2 (de) 2007-01-17
EP1070068A1 (de) 2001-01-24
AU758241B2 (en) 2003-03-20
EP1070068B1 (de) 2003-10-08
DE69911935T2 (de) 2004-09-09
DE69911935D1 (de) 2003-11-13
JP2002506868A (ja) 2002-03-05
DE69911935T3 (de) 2008-02-07
AU2821999A (en) 1999-10-11

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