ZA791702B - Novel mercaptoimidazole derivatives - Google Patents
Novel mercaptoimidazole derivativesInfo
- Publication number
- ZA791702B ZA791702B ZA791702A ZA791702A ZA791702B ZA 791702 B ZA791702 B ZA 791702B ZA 791702 A ZA791702 A ZA 791702A ZA 791702 A ZA791702 A ZA 791702A ZA 791702 B ZA791702 B ZA 791702B
- Authority
- ZA
- South Africa
- Prior art keywords
- novel
- mercaptoimidazole derivatives
- mercaptoimidazole
- derivatives
- novel mercaptoimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU79412 | 1978-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA791702B true ZA791702B (en) | 1980-04-30 |
Family
ID=19728887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA791702A ZA791702B (en) | 1978-04-11 | 1979-04-10 | Novel mercaptoimidazole derivatives |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US4461770A (es) |
| EP (1) | EP0004648B1 (es) |
| JP (1) | JPS54135769A (es) |
| KR (2) | KR820002314B1 (es) |
| AT (1) | AT376971B (es) |
| AU (1) | AU532402B2 (es) |
| CS (1) | CS220324B2 (es) |
| CY (1) | CY1302A (es) |
| DD (1) | DD142712A5 (es) |
| DE (1) | DE2963572D1 (es) |
| DK (1) | DK148879A (es) |
| ES (5) | ES479490A0 (es) |
| FI (1) | FI65066C (es) |
| GR (1) | GR71193B (es) |
| HK (1) | HK87285A (es) |
| HU (1) | HU182018B (es) |
| IL (1) | IL57040A (es) |
| MY (1) | MY8600271A (es) |
| NO (1) | NO148926C (es) |
| NZ (1) | NZ190153A (es) |
| PL (2) | PL125972B1 (es) |
| PT (1) | PT69460A (es) |
| SU (2) | SU1259962A3 (es) |
| ZA (1) | ZA791702B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2823197A1 (de) * | 1978-05-24 | 1979-11-29 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE2856909A1 (de) * | 1978-12-28 | 1980-07-17 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3025484A1 (de) * | 1980-07-03 | 1982-02-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| US4686231A (en) * | 1985-12-12 | 1987-08-11 | Smithkline Beckman Corporation | Inhibition of 5-lipoxygenase products |
| US4780470A (en) * | 1986-08-19 | 1988-10-25 | Smithkline Beckman Corporation | Inhibition of interleukin-1 by monocytes and/or macrophages |
| FI91754C (fi) * | 1986-12-02 | 1994-08-10 | Tanabe Seiyaku Co | Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi |
| US5955480A (en) * | 1996-11-20 | 1999-09-21 | Merck & Co., Inc. | Triaryl substituted imidazoles, compositions containing such compounds and methods of use |
| CN1211381C (zh) * | 1997-04-24 | 2005-07-20 | 奥索·麦克尼尔药品公司 | 用于治疗炎性疾病的取代咪唑 |
| US6040320A (en) * | 1997-06-30 | 2000-03-21 | Ortho-Mcneil Pharmaceutical, Inc. | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
| DE19842833B4 (de) * | 1998-09-18 | 2005-04-14 | Merckle Gmbh | 2-Arylalkylthio-imidazole, 2-Arylalkenylthio-imidazole und 2-Arylalkinylthio-imidazole als Entzündungs-Hemmstoffe und Hemmstoffe der Cytokin-Freisetzung |
| DE10107683A1 (de) | 2001-02-19 | 2002-08-29 | Merckle Gmbh Chem Pharm Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| DE10238045A1 (de) * | 2002-08-20 | 2004-03-04 | Merckle Gmbh Chem.-Pharm. Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| US8134029B2 (en) | 2002-09-16 | 2012-03-13 | Sunovion Pharmaceuticals Inc. | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine |
| US20080293726A1 (en) | 2005-07-06 | 2008-11-27 | Sepracor Inc. | Combinations of Eszopiclone and Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-N-Methyl-1-Napthalenamine or Trans 4-(3,4-Dichlorophenyl)-1,2,3,4-Tetrahydro-1-Napthalenamine, and Methods of Treatment of Menopause and Mood, Anxiety, and Cognitive Disorders |
| CN103588659A (zh) | 2006-03-31 | 2014-02-19 | 赛诺维信制药公司 | 手性酰胺和胺的制备 |
| EP1894925A1 (en) * | 2006-08-24 | 2008-03-05 | Merckle Gmbh | Imidazole compounds having an antiinflammatory effect |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2981739A (en) * | 1958-01-27 | 1961-04-25 | Diamond Alkali Co | Certain alpha-haloaldehyde addition products of ethylenethioureas and process |
| US3714179A (en) * | 1970-09-08 | 1973-01-30 | Searle & Co | 1-alkyl-2-furfurylthioimidazoles and congeners |
| JPS5343958B2 (es) * | 1972-07-29 | 1978-11-24 | ||
| SE428686B (sv) * | 1975-08-11 | 1983-07-18 | Du Pont | Forfarande for framstellning av antiinflammatoriskt aktiva imidazoler |
| DK16778A (da) * | 1977-02-09 | 1978-08-10 | Du Pont | Imidazolderivater deres anvendelser og fremstilling |
| US4159338A (en) * | 1977-02-09 | 1979-06-26 | E. I. Du Pont De Nemours And Company | Antiinflammatory-4,5-dicyclic-2-(substituted thio)-imidazoles and their corresponding sulfoxides and sulfones |
| LU77703A1 (de) * | 1977-07-07 | 1979-03-26 | Ciba Geigy Ag | Verfahren zur herstellung von bicyclischen thia-diaza-verbindungen |
| DE2823197A1 (de) * | 1978-05-24 | 1979-11-29 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| US4308277A (en) * | 1978-08-10 | 1981-12-29 | Ciba-Geigy Corporation | 2,4,5-Trisubstituted imidazolines and pharmaceutical compositions containing same |
| US4175127A (en) * | 1978-09-27 | 1979-11-20 | Smithkline Corporation | Pyridyl substituted 2,3-dihydroimidazo[2,1-b]thiazoles |
| DE2856909A1 (de) * | 1978-12-28 | 1980-07-17 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
-
1979
- 1979-03-30 CY CY1302A patent/CY1302A/xx unknown
- 1979-03-30 DE DE7979100962T patent/DE2963572D1/de not_active Expired
- 1979-03-30 EP EP79100962A patent/EP0004648B1/de not_active Expired
- 1979-04-06 GR GR58824A patent/GR71193B/el unknown
- 1979-04-06 PL PL1979214745A patent/PL125972B1/pl unknown
- 1979-04-06 PL PL1979226123A patent/PL125882B1/pl unknown
- 1979-04-09 DD DD79212098A patent/DD142712A5/de unknown
- 1979-04-09 FI FI791158A patent/FI65066C/fi not_active IP Right Cessation
- 1979-04-10 AT AT0266179A patent/AT376971B/de not_active IP Right Cessation
- 1979-04-10 SU SU2747651A patent/SU1259962A3/ru active
- 1979-04-10 DK DK148879A patent/DK148879A/da not_active IP Right Cessation
- 1979-04-10 NO NO791228A patent/NO148926C/no unknown
- 1979-04-10 KR KR7901118A patent/KR820002314B1/ko active
- 1979-04-10 IL IL57040A patent/IL57040A/xx unknown
- 1979-04-10 AU AU45994/79A patent/AU532402B2/en not_active Ceased
- 1979-04-10 ZA ZA791702A patent/ZA791702B/xx unknown
- 1979-04-10 ES ES479490A patent/ES479490A0/es active Granted
- 1979-04-10 PT PT69460A patent/PT69460A/pt unknown
- 1979-04-10 CS CS792438A patent/CS220324B2/cs unknown
- 1979-04-10 NZ NZ190153A patent/NZ190153A/en unknown
- 1979-04-10 HU HU79CI1925A patent/HU182018B/hu unknown
- 1979-04-11 JP JP4311779A patent/JPS54135769A/ja active Granted
-
1980
- 1980-05-23 SU SU802925099A patent/SU991945A3/ru active
-
1981
- 1981-11-16 US US06/321,840 patent/US4461770A/en not_active Expired - Fee Related
-
1982
- 1982-09-16 ES ES515766A patent/ES515766A0/es active Granted
- 1982-10-04 KR KR8204468A patent/KR820002315B1/ko active
-
1983
- 1983-12-30 ES ES528579A patent/ES528579A0/es active Granted
- 1983-12-30 ES ES528581A patent/ES528581A0/es active Granted
- 1983-12-30 ES ES528580A patent/ES528580A0/es active Granted
-
1984
- 1984-03-09 US US06/588,024 patent/US4584310A/en not_active Expired - Fee Related
- 1984-03-09 US US06/588,025 patent/US4608382A/en not_active Expired - Fee Related
-
1985
- 1985-11-07 HK HK872/85A patent/HK87285A/xx unknown
-
1986
- 1986-12-30 MY MY271/86A patent/MY8600271A/xx unknown
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