ATE243207T1 - Verfahren zur herstellung von simvastatin und ihren derivaten - Google Patents

Verfahren zur herstellung von simvastatin und ihren derivaten

Info

Publication number
ATE243207T1
ATE243207T1 AT99936072T AT99936072T ATE243207T1 AT E243207 T1 ATE243207 T1 AT E243207T1 AT 99936072 T AT99936072 T AT 99936072T AT 99936072 T AT99936072 T AT 99936072T AT E243207 T1 ATE243207 T1 AT E243207T1
Authority
AT
Austria
Prior art keywords
protecting group
formula
derivatives
diol lactone
iia
Prior art date
Application number
AT99936072T
Other languages
English (en)
Inventor
Silvo Zupancic
Anton Stimac
Joze Gnidovec
Original Assignee
Krka Tovarna Zdravil D D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil D D filed Critical Krka Tovarna Zdravil D D
Application granted granted Critical
Publication of ATE243207T1 publication Critical patent/ATE243207T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT99936072T 1998-02-26 1999-02-24 Verfahren zur herstellung von simvastatin und ihren derivaten ATE243207T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9800057A SI9800057A (sl) 1998-02-26 1998-02-26 Postopek za pripravo simvastatina in njegovih derivatov
PCT/SI1999/000006 WO1999043665A1 (en) 1998-02-26 1999-02-24 Process for the preparation of simvastatin and derivatives thereof

Publications (1)

Publication Number Publication Date
ATE243207T1 true ATE243207T1 (de) 2003-07-15

Family

ID=20432210

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99936072T ATE243207T1 (de) 1998-02-26 1999-02-24 Verfahren zur herstellung von simvastatin und ihren derivaten

Country Status (18)

Country Link
US (1) US6252091B1 (de)
EP (1) EP1056737B1 (de)
AT (1) ATE243207T1 (de)
AU (1) AU3284699A (de)
BG (1) BG64826B1 (de)
CZ (1) CZ297405B6 (de)
DE (1) DE69908909T2 (de)
EA (1) EA002370B1 (de)
EE (1) EE04345B1 (de)
HR (1) HRP20000467B1 (de)
HU (1) HU227916B1 (de)
NO (1) NO326301B1 (de)
PL (1) PL194713B1 (de)
RS (1) RS49712B (de)
SI (1) SI9800057A (de)
SK (1) SK284137B6 (de)
UA (1) UA56303C2 (de)
WO (1) WO1999043665A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20116A (sl) 1998-12-02 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nov postopek za pripravo simvastatina in njegovih analogov
AU1683000A (en) * 1998-12-10 2000-06-26 Kaneka Corporation Process for producing simvastatin
US6573385B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and novel intermediates thereof
US6573392B1 (en) 1999-11-11 2003-06-03 Biocon India Limited Process for manufacturing simvastatin and the novel intermediates
CN1446088A (zh) 2000-07-27 2003-10-01 普拉斯化学品有限公司 高度纯化的辛伐他汀组合物
US6603022B1 (en) 2002-05-10 2003-08-05 Biocon India Limited Process for manufacturing Simvastatin and novel intermediates thereof
SK285772B6 (sk) * 2002-11-20 2007-08-02 Zentiva, A. S. Spôsob prípravy simvastatínu
CN102070587B (zh) * 2011-01-13 2015-10-14 广东东阳光药业有限公司 一锅法制备辛伐他汀的方法
WO2014168933A1 (en) 2013-04-08 2014-10-16 Cytodyn Inc. Felinized antibodies and methods of treating retroviral infections in felines
CN104311517B (zh) * 2014-10-17 2017-06-06 上海应用技术学院 他汀内酯脱水化合物及其用途
CN104356120B (zh) * 2014-10-17 2017-05-03 上海应用技术学院 多取代喹啉类他汀内酯脱水化合物及其用途
CN105111173B (zh) * 2015-06-26 2017-06-23 上海应用技术学院 他汀含氟衍生物及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR69216B (de) 1979-06-15 1982-05-07 Merck & Co Inc
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
DE3480923D1 (de) * 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
US4845237A (en) * 1987-04-15 1989-07-04 Merck & Co., Inc. Acylation process for the synthesis of HMG-CoA reductase inhibitors
US4820850A (en) * 1987-07-10 1989-04-11 Merck & Co., Inc. Process for α-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
CA2036962C (en) 1990-02-26 1998-09-15 Ann E. Decamp Process for the desilylation of a 4-silyloxy-tetrahydro-pyran-2-one
US5223415A (en) * 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
SI9500238A (en) 1995-07-27 1997-02-28 Krka Tovarna Zdravil Procedure for the production of lovastatin

Also Published As

Publication number Publication date
NO20004221D0 (no) 2000-08-23
SI9800057A (sl) 1999-08-31
HRP20000467B1 (en) 2009-02-28
AU3284699A (en) 1999-09-15
RS49712B (sr) 2007-12-31
CZ297405B6 (cs) 2006-12-13
EA200000881A1 (ru) 2001-02-26
UA56303C2 (uk) 2003-05-15
SK284137B6 (sk) 2004-09-08
DE69908909D1 (de) 2003-07-24
PL342511A1 (en) 2001-06-18
US6252091B1 (en) 2001-06-26
HRP20000467A2 (en) 2001-02-28
HUP0100743A2 (hu) 2001-11-28
SK12582000A3 (sk) 2002-01-07
EP1056737B1 (de) 2003-06-18
DE69908909T2 (de) 2003-12-04
NO20004221L (no) 2000-08-23
BG64826B1 (bg) 2006-05-31
WO1999043665A1 (en) 1999-09-02
EA002370B1 (ru) 2002-04-25
HUP0100743A3 (en) 2002-04-29
HU227916B1 (en) 2012-06-28
YU46600A (sh) 2003-12-31
PL194713B1 (pl) 2007-06-29
CZ20002857A3 (cs) 2000-11-15
BG104749A (en) 2001-04-30
EE04345B1 (et) 2004-08-16
EP1056737A1 (de) 2000-12-06
EE200000479A (et) 2002-02-15
NO326301B1 (no) 2008-11-03

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties