DE69732413D1 - Verfahren zur synthese chemischer verbindungen mit pde-iv-hemmender wirkung - Google Patents

Verfahren zur synthese chemischer verbindungen mit pde-iv-hemmender wirkung

Info

Publication number
DE69732413D1
DE69732413D1 DE69732413T DE69732413T DE69732413D1 DE 69732413 D1 DE69732413 D1 DE 69732413D1 DE 69732413 T DE69732413 T DE 69732413T DE 69732413 T DE69732413 T DE 69732413T DE 69732413 D1 DE69732413 D1 DE 69732413D1
Authority
DE
Germany
Prior art keywords
pde
hemmender
synthesis
effect
chemical compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69732413T
Other languages
English (en)
Other versions
DE69732413T2 (de
Inventor
Mark Chasin
Peter Hofer
David Cavalla
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Application granted granted Critical
Publication of DE69732413D1 publication Critical patent/DE69732413D1/de
Publication of DE69732413T2 publication Critical patent/DE69732413T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE69732413T 1996-06-06 1997-06-06 Verfahren zur synthese chemischer verbindungen mit pde-iv-hemmender wirkung Expired - Fee Related DE69732413T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/659,767 US5864037A (en) 1996-06-06 1996-06-06 Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US659767 1996-06-06
PCT/US1997/010960 WO1997046561A1 (en) 1996-06-06 1997-06-06 Improved methods for the synthesis of chemical compounds having pde-iv inhibitory activity

Publications (2)

Publication Number Publication Date
DE69732413D1 true DE69732413D1 (de) 2005-03-10
DE69732413T2 DE69732413T2 (de) 2005-12-22

Family

ID=24646754

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69732413T Expired - Fee Related DE69732413T2 (de) 1996-06-06 1997-06-06 Verfahren zur synthese chemischer verbindungen mit pde-iv-hemmender wirkung

Country Status (8)

Country Link
US (2) US5864037A (de)
EP (1) EP0912575B1 (de)
JP (1) JP2000507599A (de)
AT (1) ATE288435T1 (de)
AU (1) AU735198B2 (de)
CA (1) CA2257807C (de)
DE (1) DE69732413T2 (de)
WO (1) WO1997046561A1 (de)

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US6426084B1 (en) 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6132757A (en) 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6187790B1 (en) 1999-03-04 2001-02-13 Neal R. Cutler Use of cilostazol for treatment of sexual dysfunction
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US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
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US20030096748A1 (en) * 2001-06-04 2003-05-22 The Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
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US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US7208628B2 (en) * 2002-05-13 2007-04-24 Kansas State University Research Foundation Compositions and methods for the treatment of hepatitis C virus infection
US7074893B2 (en) * 2002-06-03 2006-07-11 Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
CN1688580A (zh) * 2002-08-08 2005-10-26 记忆药物公司 作为磷酸二酯酶4抑制剂的2－三氟甲基－6－氨基嘌呤衍生物
CN100415747C (zh) * 2002-08-08 2008-09-03 记忆药物公司 磷酸二酯酶4抑制剂
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ES2842523T3 (es) 2015-05-15 2021-07-14 Univ Michigan Regents Métodos y composiciones para el tratamiento de la artritis
CA3079848A1 (en) 2017-11-07 2019-05-16 The Regents Of The University Of Michigan Small molecule inhibitors of shared epitope-calreticulin interactions and methods of use

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Also Published As

Publication number Publication date
JP2000507599A (ja) 2000-06-20
US6310205B1 (en) 2001-10-30
CA2257807A1 (en) 1997-12-11
DE69732413T2 (de) 2005-12-22
CA2257807C (en) 2002-09-24
WO1997046561A1 (en) 1997-12-11
ATE288435T1 (de) 2005-02-15
US5864037A (en) 1999-01-26
EP0912575A4 (de) 2001-04-25
EP0912575B1 (de) 2005-02-02
EP0912575A1 (de) 1999-05-06
AU735198B2 (en) 2001-07-05
AU3410097A (en) 1998-01-05

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