ATE288435T1 - Verfahren zur synthese chemischer verbindungen mit pde-iv-hemmender wirkung - Google Patents

Verfahren zur synthese chemischer verbindungen mit pde-iv-hemmender wirkung

Info

Publication number
ATE288435T1
ATE288435T1 AT97930217T AT97930217T ATE288435T1 AT E288435 T1 ATE288435 T1 AT E288435T1 AT 97930217 T AT97930217 T AT 97930217T AT 97930217 T AT97930217 T AT 97930217T AT E288435 T1 ATE288435 T1 AT E288435T1
Authority
AT
Austria
Prior art keywords
pde
synthesis
chemical compounds
inhibiting effect
compounds
Prior art date
Application number
AT97930217T
Other languages
English (en)
Inventor
Mark Chasin
Peter Hofer
David Cavalla
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of ATE288435T1 publication Critical patent/ATE288435T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97930217T 1996-06-06 1997-06-06 Verfahren zur synthese chemischer verbindungen mit pde-iv-hemmender wirkung ATE288435T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/659,767 US5864037A (en) 1996-06-06 1996-06-06 Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
PCT/US1997/010960 WO1997046561A1 (en) 1996-06-06 1997-06-06 Improved methods for the synthesis of chemical compounds having pde-iv inhibitory activity

Publications (1)

Publication Number Publication Date
ATE288435T1 true ATE288435T1 (de) 2005-02-15

Family

ID=24646754

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97930217T ATE288435T1 (de) 1996-06-06 1997-06-06 Verfahren zur synthese chemischer verbindungen mit pde-iv-hemmender wirkung

Country Status (8)

Country Link
US (2) US5864037A (de)
EP (1) EP0912575B1 (de)
JP (1) JP2000507599A (de)
AT (1) ATE288435T1 (de)
AU (1) AU735198B2 (de)
CA (1) CA2257807C (de)
DE (1) DE69732413T2 (de)
WO (1) WO1997046561A1 (de)

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US6426084B1 (en) * 2000-06-19 2002-07-30 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
US6132757A (en) * 1998-05-01 2000-10-17 Neal R. Cutler Treatment of sexual dysfunction in certain patient groups
ATE279113T1 (de) * 1999-08-12 2004-10-15 Euro Celtique Sa Hypoxanthin- und thiohypxanthin-verbindungen
US6458804B1 (en) * 2001-01-26 2002-10-01 R.T. Alamo Venturesi, Llc Methods for the treatment of central nervous system disorders in certain patient groups
US6562838B2 (en) 2001-01-26 2003-05-13 R. T. Alamo Ventures I, L.L.C. Treatment of cardiovascular disease with quinolinone enantiomers
US6451813B1 (en) 2001-01-26 2002-09-17 R. T. Alamo Ventures I, Llc Treatment of gastroparesis in certain patient groups
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US20030096748A1 (en) * 2001-06-04 2003-05-22 The Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
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US7041677B2 (en) * 2002-03-01 2006-05-09 R.T. Alamo Ventures I, Llc Use of monochloroflosequinan in the treatment of sexual dysfunction
US7208628B2 (en) * 2002-05-13 2007-04-24 Kansas State University Research Foundation Compositions and methods for the treatment of hepatitis C virus infection
US7074893B2 (en) * 2002-06-03 2006-07-11 Regents Of The University Of Michigan Methods and compositions for the treatment of diseases associated with signal transduction aberrations
WO2004014913A2 (en) * 2002-08-08 2004-02-19 Memory Pharmaceuticals Corporation Derivatives of 2-trifluormethyl-6-aminopurine as phosphodiesterase 4 inhibitors
WO2004014911A1 (en) * 2002-08-08 2004-02-19 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
AU2003284142A1 (en) * 2002-10-15 2004-05-04 Synta Pharmaceuticals Corp Aromatic bicyclic heterocyles to modulate 1L-12 production
US20050089558A1 (en) * 2003-10-28 2005-04-28 Alamo Pharmaceuticals, Llc Compositions and methods for the co-formulation and administration of tramadol and propoxyphene
EP1687002A4 (de) * 2003-11-10 2008-07-23 Synta Pharmaceuticals Corp Kondensierte heterozyklische verbindungen
JP6897971B2 (ja) 2015-05-15 2021-07-07 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 関節炎を処置するための、方法および組成物
KR20200085278A (ko) 2017-11-07 2020-07-14 더 리젠츠 오브 더 유니버시티 오브 미시건 공유 에피토프-칼레티쿨린 상호 작용의 소분자 억제제　및 사용 방법

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Also Published As

Publication number Publication date
AU735198B2 (en) 2001-07-05
EP0912575A4 (de) 2001-04-25
US5864037A (en) 1999-01-26
WO1997046561A1 (en) 1997-12-11
JP2000507599A (ja) 2000-06-20
EP0912575B1 (de) 2005-02-02
DE69732413T2 (de) 2005-12-22
AU3410097A (en) 1998-01-05
EP0912575A1 (de) 1999-05-06
CA2257807A1 (en) 1997-12-11
US6310205B1 (en) 2001-10-30
DE69732413D1 (de) 2005-03-10
CA2257807C (en) 2002-09-24

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