DE69521199D1 - Verbessertes verfahren zur herstellung von carbapenem zwischenprodukten - Google Patents

Verbessertes verfahren zur herstellung von carbapenem zwischenprodukten

Info

Publication number
DE69521199D1
DE69521199D1 DE69521199T DE69521199T DE69521199D1 DE 69521199 D1 DE69521199 D1 DE 69521199D1 DE 69521199 T DE69521199 T DE 69521199T DE 69521199 T DE69521199 T DE 69521199T DE 69521199 D1 DE69521199 D1 DE 69521199D1
Authority
DE
Germany
Prior art keywords
carbapen
producing
improved method
intermediate products
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69521199T
Other languages
English (en)
Other versions
DE69521199T2 (de
Inventor
Meng-Han Liu
E Lynch
P Volante
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69521199D1 publication Critical patent/DE69521199D1/de
Publication of DE69521199T2 publication Critical patent/DE69521199T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69521199T 1994-01-25 1995-01-20 Verbessertes verfahren zur herstellung von carbapenem zwischenprodukten Expired - Fee Related DE69521199T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/186,207 US5493018A (en) 1994-01-25 1994-01-25 Process for synthesizing carbapenem intermediates using a rhodium catalyst and lewis acid
PCT/US1995/000855 WO1995019979A1 (en) 1994-01-25 1995-01-20 Improved process for synthesizing carbapenem intermediates

Publications (2)

Publication Number Publication Date
DE69521199D1 true DE69521199D1 (de) 2001-07-12
DE69521199T2 DE69521199T2 (de) 2001-11-08

Family

ID=22684063

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69521199T Expired - Fee Related DE69521199T2 (de) 1994-01-25 1995-01-20 Verbessertes verfahren zur herstellung von carbapenem zwischenprodukten

Country Status (12)

Country Link
US (1) US5493018A (de)
EP (1) EP0741728B1 (de)
JP (1) JPH09508124A (de)
AT (1) ATE201874T1 (de)
AU (1) AU677762B2 (de)
CA (1) CA2178935A1 (de)
DE (1) DE69521199T2 (de)
DK (1) DK0741728T3 (de)
ES (1) ES2157323T3 (de)
GR (1) GR3036005T3 (de)
PT (1) PT741728E (de)
WO (1) WO1995019979A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7682603B2 (en) * 2003-07-25 2010-03-23 The Trustees Of The University Of Pennsylvania Polymersomes incorporating highly emissive probes
KR100959027B1 (ko) 2007-11-12 2010-05-24 성균관대학교산학협력단 아연 화합물을 보조 촉매로 이용하는 페넴 중간체의 제조방법
CA2732619A1 (en) * 2008-07-30 2010-02-04 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
KR101049267B1 (ko) * 2008-10-22 2011-07-13 제이더블유중외제약 주식회사 베타-메틸 비닐 포스페이트 카바페넴의 입체 선택적 제조방법
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
CN101891766A (zh) * 2010-07-20 2010-11-24 深圳市海滨制药有限公司 一种β甲基碳青霉烯类抗生素母核的制备方法
US10695322B2 (en) 2016-01-29 2020-06-30 The Johns Hopkins University Inhibitors of bacterial growth

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4287123A (en) * 1980-01-14 1981-09-01 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
US4499278A (en) * 1980-01-14 1985-02-12 Merck & Co., Inc. Trans-3-carboxymethylene-4-carboxy-5-methyl-delta2-isoxazoline as intermediate
US4349687A (en) * 1980-01-14 1982-09-14 Merck & Co., Inc. Intermediate for synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
US4739048A (en) * 1980-05-29 1988-04-19 Merck & Co., Inc. Process for the preparation of thienamycin and intermediates
US4378315A (en) * 1980-05-29 1983-03-29 Merck & Co., Inc. Process for the preparation of thienamycin and intermediates
US4467107A (en) * 1981-04-08 1984-08-21 Merck & Co., Inc. 1-Hydroxyethyl-2-amino pentanedioic acid derivatives
US4473502A (en) * 1981-04-08 1984-09-25 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
US4816577A (en) * 1986-04-07 1989-03-28 Merck & Co., Inc. Process for producing 1-beta-methylcarbapenem antibiotic intermediates
US4866171A (en) * 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
US5051502A (en) * 1990-06-06 1991-09-24 University Of Notre Dame Du Lac Rhodium catalyzed cyclization process for bicyclic β-lactams

Also Published As

Publication number Publication date
WO1995019979A1 (en) 1995-07-27
EP0741728B1 (de) 2001-06-06
EP0741728A4 (de) 1997-04-02
DE69521199T2 (de) 2001-11-08
ATE201874T1 (de) 2001-06-15
JPH09508124A (ja) 1997-08-19
PT741728E (pt) 2001-09-28
AU677762B2 (en) 1997-05-01
US5493018A (en) 1996-02-20
GR3036005T3 (en) 2001-09-28
EP0741728A1 (de) 1996-11-13
ES2157323T3 (es) 2001-08-16
CA2178935A1 (en) 1995-07-27
DK0741728T3 (da) 2001-09-03
AU1730295A (en) 1995-08-08

Similar Documents

Publication Publication Date Title
ATE229960T1 (de) Verfahren zur herstellung von 13-ether-derivaten von milbemycinen und zwischenprodukte
DE69619443D1 (de) Ungesättigte Hydroxycarbonsäureverbindungen als Zwischenprodukte zur Herstellung von Schmierstoff- und Kraftstoffadditiven
ATE148702T1 (de) Verfahren zur herstellung von imidazopyridinderivaten
ATE136899T1 (de) Verfahren zur herstellung eines n- phenylacetylderivats von tetrahydrothieno(3,2- c>pyridin und zwischenprodukt der synthese
ATE239008T1 (de) Verfahren zur herstellung von (+/-) calanolide a und zwischenprodukte dafür
DE69207429D1 (de) Verfahren zur herstellung von substituierten piperidinen
ATE90676T1 (de) Dioxyalkylenaryl-dihydropyridine zwischenprodukte zu ihrer herstellung, verfahren zu ihrer herstellung und ihre verwendung.
DE69008851D1 (de) VERFAHREN ZUR HERSTELLUNG VON 5,6,7, -TRINOR- 4,8,-INTER-m-PHENYLEN PGI,2 Abkömmlingen.
DE69521199D1 (de) Verbessertes verfahren zur herstellung von carbapenem zwischenprodukten
ATE156480T1 (de) Verfahren zur herstellung von zwischenprodukten für die synthese von chinolin-antibiotika
ATE229006T1 (de) Verfahren zur herstellung von schwefelhaltigen imidazolderivaten und erhaltene zwischenprodukte
DE59602845D1 (de) Verfahren zur Herstellung aromatischer Verbindungen durch Decarboxylierung aromatischer Carbonsäuren
DE3764875D1 (de) Verfahren zur herstellung von penemderivaten.
ATE119533T1 (de) Verfahren zur herstellung von 1-oxa-3, 8-diaza-4- oxo-spiro-(4,5>decan-verbindungen.
ATE234288T1 (de) Verfahren zur herstellung eines buthylthuio- isochinolinderivates und zwischenprodukte dafür
FI951350A0 (fi) Menetelmä substituoitujen imisadsoliyhdisteiden käyttökelpoisten välituotteiden syntetisoimiseksi
ATE182335T1 (de) ''steroidzwischenprodukte und verfahren zu ihrer herstellung''
DE3582345D1 (de) Verfahren zur herstellung eines optisch aktiven lactons und neue zwischenprodukte in diesem verfahren.
ATE185565T1 (de) Verfahren und zwischenprodukte zur herstellung von bis-aza-bicyclischen anxiolytica
ATE222585T1 (de) Verfahren zur herstellung von 4-hydroxy-2- pyrrolidon
ATE159016T1 (de) Verfahren zur herstellung von 5-amino-2,2-dialkyl-1,3-dioxan
FI902590A0 (fi) Foerfarande foer framstaellning av 2-oxoindol-1-karboxamider.
DE69406451D1 (de) Verfahren zur herstellung von n-carbonylarylimine als zwischenprodukte in der synthese von therapeutisch aktiven taxol-derivaten
DE69619402D1 (de) Verfahren zur herstellung von methoximinophenylglyoxylsäure-derivaten
DE69312085D1 (de) Verfarhen zur herstellung von alpha-aryl-gamma-butyrolactonen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee