DK0741728T3 - Forbedret fremgangsmåde til syntese af carbapenemmellemprodukter - Google Patents

Forbedret fremgangsmåde til syntese af carbapenemmellemprodukter

Info

Publication number
DK0741728T3
DK0741728T3 DK95909293T DK95909293T DK0741728T3 DK 0741728 T3 DK0741728 T3 DK 0741728T3 DK 95909293 T DK95909293 T DK 95909293T DK 95909293 T DK95909293 T DK 95909293T DK 0741728 T3 DK0741728 T3 DK 0741728T3
Authority
DK
Denmark
Prior art keywords
synthesis
carbapene
intermediates
improved method
compound
Prior art date
Application number
DK95909293T
Other languages
Danish (da)
English (en)
Inventor
Thomas Meng-Han Liu
Joseph E Lynch
Ralph P Volante
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0741728T3 publication Critical patent/DK0741728T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK95909293T 1994-01-25 1995-01-20 Forbedret fremgangsmåde til syntese af carbapenemmellemprodukter DK0741728T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/186,207 US5493018A (en) 1994-01-25 1994-01-25 Process for synthesizing carbapenem intermediates using a rhodium catalyst and lewis acid
PCT/US1995/000855 WO1995019979A1 (en) 1994-01-25 1995-01-20 Improved process for synthesizing carbapenem intermediates

Publications (1)

Publication Number Publication Date
DK0741728T3 true DK0741728T3 (da) 2001-09-03

Family

ID=22684063

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95909293T DK0741728T3 (da) 1994-01-25 1995-01-20 Forbedret fremgangsmåde til syntese af carbapenemmellemprodukter

Country Status (12)

Country Link
US (1) US5493018A (de)
EP (1) EP0741728B1 (de)
JP (1) JPH09508124A (de)
AT (1) ATE201874T1 (de)
AU (1) AU677762B2 (de)
CA (1) CA2178935A1 (de)
DE (1) DE69521199T2 (de)
DK (1) DK0741728T3 (de)
ES (1) ES2157323T3 (de)
GR (1) GR3036005T3 (de)
PT (1) PT741728E (de)
WO (1) WO1995019979A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7682603B2 (en) * 2003-07-25 2010-03-23 The Trustees Of The University Of Pennsylvania Polymersomes incorporating highly emissive probes
KR100959027B1 (ko) 2007-11-12 2010-05-24 성균관대학교산학협력단 아연 화합물을 보조 촉매로 이용하는 페넴 중간체의 제조방법
CA2732619A1 (en) * 2008-07-30 2010-02-04 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
KR101049267B1 (ko) * 2008-10-22 2011-07-13 제이더블유중외제약 주식회사 베타-메틸 비닐 포스페이트 카바페넴의 입체 선택적 제조방법
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
CN101891766A (zh) * 2010-07-20 2010-11-24 深圳市海滨制药有限公司 一种β甲基碳青霉烯类抗生素母核的制备方法
WO2017132321A1 (en) 2016-01-29 2017-08-03 The Johns Hopkins University Novel inhibitors of bacterial growth

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349687A (en) * 1980-01-14 1982-09-14 Merck & Co., Inc. Intermediate for synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
US4287123A (en) * 1980-01-14 1981-09-01 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
US4499278A (en) * 1980-01-14 1985-02-12 Merck & Co., Inc. Trans-3-carboxymethylene-4-carboxy-5-methyl-delta2-isoxazoline as intermediate
US4378315A (en) * 1980-05-29 1983-03-29 Merck & Co., Inc. Process for the preparation of thienamycin and intermediates
US4739048A (en) * 1980-05-29 1988-04-19 Merck & Co., Inc. Process for the preparation of thienamycin and intermediates
US4467107A (en) * 1981-04-08 1984-08-21 Merck & Co., Inc. 1-Hydroxyethyl-2-amino pentanedioic acid derivatives
US4473502A (en) * 1981-04-08 1984-09-25 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-[1 (SR)-hydroxyethyl]-2-oxo-4-azetidineacetic acid
US4816577A (en) * 1986-04-07 1989-03-28 Merck & Co., Inc. Process for producing 1-beta-methylcarbapenem antibiotic intermediates
US4866171A (en) * 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
US5051502A (en) * 1990-06-06 1991-09-24 University Of Notre Dame Du Lac Rhodium catalyzed cyclization process for bicyclic β-lactams

Also Published As

Publication number Publication date
AU1730295A (en) 1995-08-08
ATE201874T1 (de) 2001-06-15
GR3036005T3 (en) 2001-09-28
CA2178935A1 (en) 1995-07-27
JPH09508124A (ja) 1997-08-19
US5493018A (en) 1996-02-20
WO1995019979A1 (en) 1995-07-27
PT741728E (pt) 2001-09-28
EP0741728B1 (de) 2001-06-06
EP0741728A4 (de) 1997-04-02
DE69521199D1 (de) 2001-07-12
DE69521199T2 (de) 2001-11-08
ES2157323T3 (es) 2001-08-16
AU677762B2 (en) 1997-05-01
EP0741728A1 (de) 1996-11-13

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