ATE417831T1 - Ceramid ähnliche verbindungen, verfahren zu deren herstellung und deren verwendung als antitumormittel - Google Patents
Ceramid ähnliche verbindungen, verfahren zu deren herstellung und deren verwendung als antitumormittelInfo
- Publication number
- ATE417831T1 ATE417831T1 AT00956250T AT00956250T ATE417831T1 AT E417831 T1 ATE417831 T1 AT E417831T1 AT 00956250 T AT00956250 T AT 00956250T AT 00956250 T AT00956250 T AT 00956250T AT E417831 T1 ATE417831 T1 AT E417831T1
- Authority
- AT
- Austria
- Prior art keywords
- ceramide
- compounds
- production
- tumor agents
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- -1 ceramide analog compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999FI000169A IT1307786B1 (it) | 1999-07-22 | 1999-07-22 | Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE417831T1 true ATE417831T1 (de) | 2009-01-15 |
Family
ID=11353048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00956250T ATE417831T1 (de) | 1999-07-22 | 2000-07-21 | Ceramid ähnliche verbindungen, verfahren zu deren herstellung und deren verwendung als antitumormittel |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6956109B1 (de) |
| EP (1) | EP1198458B1 (de) |
| JP (1) | JP4652647B2 (de) |
| AT (1) | ATE417831T1 (de) |
| AU (1) | AU6826700A (de) |
| DE (1) | DE60041137D1 (de) |
| IT (1) | IT1307786B1 (de) |
| WO (1) | WO2001007418A2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2523856T3 (es) | 2000-12-22 | 2014-12-02 | Lpath, Inc. | Anticuerpos de esfingosina-1-fosfato para el tratamiento de enfermedades asociadas con elevadas concentraciones de esfingolípidos |
| US9217749B2 (en) | 2006-05-31 | 2015-12-22 | Lpath, Inc. | Immune-derived moieties reactive against lysophosphatidic acid |
| US9274130B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Prevention and treatment of pain using antibodies to lysophosphatidic acid |
| US9274129B2 (en) | 2006-05-31 | 2016-03-01 | Lpath, Inc. | Methods and reagents for detecting bioactive lipids |
| CA2667574A1 (en) | 2006-10-27 | 2008-06-12 | Roger A. Sabbadini | Compositions and methods for binding sphingosine-1-phosphate |
| DE102008023040B4 (de) * | 2008-05-09 | 2011-04-28 | Eurocopter Deutschland Gmbh | Flugführungsanzeige für einen Hubschrauber |
| US8871202B2 (en) | 2008-10-24 | 2014-10-28 | Lpath, Inc. | Prevention and treatment of pain using antibodies to sphingosine-1-phosphate |
| CA2853024C (en) | 2011-11-11 | 2017-08-22 | Pfizer Inc. | 2-thiopyrimidinones |
| PE20180503A1 (es) | 2015-05-05 | 2018-03-09 | Pfizer | 2-tiopirimidinonas |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5587777A (en) * | 1978-12-27 | 1980-07-02 | Ono Pharmaceut Co Ltd | Pyrimidine derivative, its preparation and antitumorigenic agent |
| JPH0625163B2 (ja) * | 1985-04-16 | 1994-04-06 | 久光製薬株式会社 | ウラシル誘導体 |
| KR960703010A (ko) | 1994-04-14 | 1996-06-19 | 가와구찌 시게끼 | 고사 유도제(apoptosis inducer) |
| ATE220549T1 (de) * | 1994-12-29 | 2002-08-15 | Univ California | Verbindungen zur hemmung der ceramid vermittelten signalübertragung |
| US6323201B1 (en) * | 1994-12-29 | 2001-11-27 | The Regents Of The University Of California | Compounds for inhibition of ceramide-mediated signal transduction |
-
1999
- 1999-07-22 IT IT1999FI000169A patent/IT1307786B1/it active
-
2000
- 2000-07-21 EP EP00956250A patent/EP1198458B1/de not_active Expired - Lifetime
- 2000-07-21 DE DE60041137T patent/DE60041137D1/de not_active Expired - Lifetime
- 2000-07-21 JP JP2001512504A patent/JP4652647B2/ja not_active Expired - Fee Related
- 2000-07-21 WO PCT/EP2000/007023 patent/WO2001007418A2/en active Application Filing
- 2000-07-21 AT AT00956250T patent/ATE417831T1/de not_active IP Right Cessation
- 2000-07-21 AU AU68267/00A patent/AU6826700A/en not_active Abandoned
- 2000-07-21 US US10/031,692 patent/US6956109B1/en not_active Expired - Fee Related
-
2004
- 2004-08-17 US US10/919,867 patent/US7214794B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20050020533A1 (en) | 2005-01-27 |
| JP4652647B2 (ja) | 2011-03-16 |
| AU6826700A (en) | 2001-02-13 |
| WO2001007418A2 (en) | 2001-02-01 |
| EP1198458B1 (de) | 2008-12-17 |
| DE60041137D1 (de) | 2009-01-29 |
| US7214794B2 (en) | 2007-05-08 |
| US6956109B1 (en) | 2005-10-18 |
| IT1307786B1 (it) | 2001-11-19 |
| ITFI990169A1 (it) | 2001-01-22 |
| JP2003505451A (ja) | 2003-02-12 |
| ITFI990169A0 (it) | 1999-07-22 |
| EP1198458A2 (de) | 2002-04-24 |
| WO2001007418A3 (en) | 2001-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |