EA200400944A1 - Замещенные производные тетрациклина, фармацевтическая композиция и способ лечения субъекта с их использованием - Google Patents
Замещенные производные тетрациклина, фармацевтическая композиция и способ лечения субъекта с их использованиемInfo
- Publication number
- EA200400944A1 EA200400944A1 EA200400944A EA200400944A EA200400944A1 EA 200400944 A1 EA200400944 A1 EA 200400944A1 EA 200400944 A EA200400944 A EA 200400944A EA 200400944 A EA200400944 A EA 200400944A EA 200400944 A1 EA200400944 A1 EA 200400944A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- tetracycline derivatives
- treating
- subject
- pharmaceutical composition
- substituted tetracycline
- Prior art date
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 5
- 229960002180 tetracycline Drugs 0.000 title abstract 5
- 229930101283 tetracycline Natural products 0.000 title abstract 5
- 235000019364 tetracycline Nutrition 0.000 title abstract 5
- 150000003522 tetracyclines Chemical class 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
Abstract
Настоящее изобретение относится к производным тетрациклина, замещенным в положении 9, к фармацевтическим композициям, содержащим такие производные тетрациклина, и к способам лечения заболеваний с их использованием. Предпочтительно, если представленное производное тетрациклина выбрано из группы, включающей миноциклин, санциклин, доксициклин, тетрациклин, окситетрациклин, хлортетрациклин, демеклоциклин, хелокардин, ролитетрациклин, лимециклин, метациклин, апициклин, кломоциклин, гуамециклин, меглуциклин, мепилциклин, пенимепициклин, пипациклин, этамоциклин или пенимоциклин. Согласно изобретению в положении 9 представленных соединений присутствует алкильная группа, которая может быть замещена алкенилом, алкинилом, циклоалкилом, арилом, алкилкарбонилом, алкоксикарбонилом, гидрокси, циано, арилокси, карбоксилом, арилоксикарбонилом или аминогруппой. Представленные в изобретении ранее неизвестные производные тетрациклина обладают высокой антибактериальной активностью.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15470199P | 1999-09-14 | 1999-09-14 | |
US23209100P | 2000-09-12 | 2000-09-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200400944A1 true EA200400944A1 (ru) | 2005-04-28 |
EA012203B1 EA012203B1 (ru) | 2009-08-28 |
Family
ID=26851695
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400944A EA012203B1 (ru) | 1999-09-14 | 2000-09-13 | Замещенные производные тетрациклина, фармацевтическая композиция и способ лечения субъекта с их использованием |
EA200200366A EA005118B1 (ru) | 1999-09-14 | 2000-09-13 | Замещенный аналог тетрациклина (варианты) и способ его получения (варианты) |
EA200900632A EA016099B1 (ru) | 1999-09-14 | 2000-09-13 | Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200200366A EA005118B1 (ru) | 1999-09-14 | 2000-09-13 | Замещенный аналог тетрациклина (варианты) и способ его получения (варианты) |
EA200900632A EA016099B1 (ru) | 1999-09-14 | 2000-09-13 | Замещенный аналог тетрациклина (варианты) и способ получения замещенного аналога тетрациклина |
Country Status (21)
Country | Link |
---|---|
US (3) | US6617318B1 (ru) |
EP (5) | EP2327686A3 (ru) |
JP (2) | JP5093953B2 (ru) |
KR (1) | KR100764992B1 (ru) |
CN (2) | CN102336680A (ru) |
AT (2) | ATE523485T1 (ru) |
AU (3) | AU781439C (ru) |
BR (1) | BR0013993A (ru) |
CA (2) | CA2672722C (ru) |
CY (1) | CY1105094T1 (ru) |
CZ (1) | CZ301835B6 (ru) |
DE (1) | DE60027465T2 (ru) |
DK (1) | DK1240133T3 (ru) |
EA (3) | EA012203B1 (ru) |
ES (1) | ES2260051T3 (ru) |
HR (1) | HRP20020322B1 (ru) |
HU (1) | HUP0202798A3 (ru) |
IL (4) | IL148482A0 (ru) |
MX (1) | MXPA02002595A (ru) |
PT (1) | PT1240133E (ru) |
WO (1) | WO2001019784A1 (ru) |
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BR0109725A (pt) * | 2000-03-31 | 2003-02-04 | Tufts College | Composto de tetraciclina substituìdo, método para tratar um estado responsivo a tetraciclina em um mamìfero, composição farmacêutica, método para sintetizar um composto de tetraciclina 7- ou 9-substituìdo, e, intermediário reativo |
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ATE526308T1 (de) * | 2000-07-07 | 2011-10-15 | Tufts College | 13-substituierte methacyclinverbindungen |
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