ATE523485T1 - Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemikalien - Google Patents

Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemikalien

Info

Publication number
ATE523485T1
ATE523485T1 AT06005085T AT06005085T ATE523485T1 AT E523485 T1 ATE523485 T1 AT E523485T1 AT 06005085 T AT06005085 T AT 06005085T AT 06005085 T AT06005085 T AT 06005085T AT E523485 T1 ATE523485 T1 AT E523485T1
Authority
AT
Austria
Prior art keywords
tetracycline
substituted
compounds
reactive
organic substituent
Prior art date
Application number
AT06005085T
Other languages
English (en)
Inventor
Mark L Nelson
Glen Rennie
Darrell Koza
Original Assignee
Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College filed Critical Tufts College
Application granted granted Critical
Publication of ATE523485T1 publication Critical patent/ATE523485T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
AT06005085T 1999-09-14 2000-09-13 Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemikalien ATE523485T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15470199P 1999-09-14 1999-09-14
US23209100P 2000-09-12 2000-09-12

Publications (1)

Publication Number Publication Date
ATE523485T1 true ATE523485T1 (de) 2011-09-15

Family

ID=26851695

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06005085T ATE523485T1 (de) 1999-09-14 2000-09-13 Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemikalien
AT00961860T ATE323671T1 (de) 1999-09-14 2000-09-13 Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00961860T ATE323671T1 (de) 1999-09-14 2000-09-13 Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemien

Country Status (21)

Country Link
US (3) US6617318B1 (de)
EP (5) EP2327686A3 (de)
JP (2) JP5093953B2 (de)
KR (1) KR100764992B1 (de)
CN (2) CN102336680A (de)
AT (2) ATE523485T1 (de)
AU (3) AU781439C (de)
BR (1) BR0013993A (de)
CA (2) CA2672722C (de)
CY (1) CY1105094T1 (de)
CZ (1) CZ301835B6 (de)
DE (1) DE60027465T2 (de)
DK (1) DK1240133T3 (de)
EA (3) EA012203B1 (de)
ES (1) ES2260051T3 (de)
HR (1) HRP20020322B1 (de)
HU (1) HUP0202798A3 (de)
IL (4) IL148482A0 (de)
MX (1) MXPA02002595A (de)
PT (1) PT1240133E (de)
WO (1) WO2001019784A1 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
CA2318580A1 (en) * 1998-01-23 1999-07-29 Mark L. Nelson Pharmaceutically active compounds and methods of use thereof
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
EP2327686A3 (de) * 1999-09-14 2012-08-22 Trustees Of Tufts College Verfahren zur Herstellung von substituierten Tetracyclinen mit Übergangschemien auf Metallbasis
WO2001052858A1 (en) 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
BR0109725A (pt) * 2000-03-31 2003-02-04 Tufts College Composto de tetraciclina substituìdo, método para tratar um estado responsivo a tetraciclina em um mamìfero, composição farmacêutica, método para sintetizar um composto de tetraciclina 7- ou 9-substituìdo, e, intermediário reativo
AU2001259701A1 (en) 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
MXPA03000056A (es) * 2000-07-07 2003-07-14 Tufts College Compuestos de tetraciclina sustituidos en posicion 7.
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
BRPI0112269B8 (pt) * 2000-07-07 2021-05-25 Paratek Pharm Innc composto de minociclina 9-aminometila substituída, e, composição farmacêutica
ATE526308T1 (de) * 2000-07-07 2011-10-15 Tufts College 13-substituierte methacyclinverbindungen
US20050143353A1 (en) * 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
EP2298732A1 (de) * 2001-03-13 2011-03-23 Paratek Pharmaceuticals, Inc. 7, 9-substituierte Tetracyclin-Verbindungen
EP1241160A1 (de) * 2001-03-13 2002-09-18 Glaxo Group Limited Tetracyclinderivate und ihre Verwendung als Antibiotica
AU2002250331A1 (en) * 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
CA2440757A1 (en) 2001-03-14 2002-09-19 Michael Draper Substituted tetracycline compounds as synergistic antifungal agents
US8088820B2 (en) * 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
ATE455092T1 (de) * 2001-04-24 2010-01-15 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
EP2332549A1 (de) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Neue Tetracyclinverbindungen und deren medizinischen Anwendung
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
WO2003055441A2 (en) * 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
EP1894569A3 (de) * 2001-10-05 2008-05-07 Tetragenex Pharmaceuticals, Inc. Tetracyclin-Derivate zur Behandlung von Krebserkrankungen
EP2311799A1 (de) 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-Dedimethylamin-Tetracyclinverbindungen
CN1649582A (zh) * 2002-03-08 2005-08-03 帕拉特克药品公司 氨基－甲基取代的四环素类化合物
AU2003218242A1 (en) * 2002-03-21 2003-10-08 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
WO2003079984A2 (en) * 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
JP4416652B2 (ja) * 2002-07-12 2010-02-17 パラテック ファーマシューティカルズ インコーポレイテッド ３、１０、および１２ａ置換されたテトラサイクリン化合物
CA2503446C (en) * 2002-10-24 2012-12-18 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate rna
KR100522446B1 (ko) * 2003-01-07 2005-10-18 한국생명공학연구원 아실 코에이:콜레스테롤 아실 트란스퍼라제의 저해활성을갖는 화합물 또는 그 염을 유효성분으로 하는 살충제
CN1845897A (zh) * 2003-07-09 2006-10-11 帕拉特克药品公司 取代的四环素化合物
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
CN103214409B (zh) 2004-05-21 2015-10-21 哈佛大学校长及研究员协会 四环素及其类似物的合成
TWI261038B (en) * 2004-08-11 2006-09-01 Bo-Cheng Chen Bicycle gear-shifting handgrip
WO2006047671A2 (en) * 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP2284164A3 (de) 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen
CA2597212A1 (en) 2005-02-04 2006-08-10 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
WO2007014154A2 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
WO2007117639A2 (en) * 2006-04-07 2007-10-18 The President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
CA2652346A1 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
US7763735B2 (en) * 2006-10-11 2010-07-27 President And Fellows Of Harvard College Synthesis of enone intermediate
WO2008045507A2 (en) 2006-10-11 2008-04-17 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of bacillus anthracis infections
ES2701725T3 (es) 2006-12-21 2019-02-25 Paratek Pharm Innc Compuestos de tetraciclina sustituida para el tratamiento de trastornos inflamatorios de la piel
JP5583411B2 (ja) * 2006-12-21 2014-09-03 パラテック ファーマシューティカルズ インコーポレイテッド 細菌感染、ウイルス感染、および寄生虫感染の治療のためのテトラサイクリン誘導体
US7935687B2 (en) * 2007-04-12 2011-05-03 Paratek Pharmaceuticals, Inc. Methods for treating spinal muscular atrophy using tetracycline compounds
EP2213655A1 (de) 2007-04-27 2010-08-04 Paratek Pharmaceuticals, Inc. Verfahren zur Reinigung von Aminoalkyl-Tetracyclinverbindungen
EA201070048A1 (ru) 2007-07-06 2010-10-29 Паратек Фармасьютикалс, Инк. Способы синтеза замещённых соединений тетрациклина (варианты)
NZ586445A (en) 2007-11-29 2012-06-29 Actelion Pharmaceuticals Ltd Phosphonic acid derivates and their use as p2y12 receptor antagonists
JP2011513404A (ja) 2008-03-05 2011-04-28 パラテック ファーマシューティカルズ インコーポレイテッド ミノサイクリン化合物およびその使用方法
US20100022483A1 (en) * 2008-04-14 2010-01-28 Paratek Pharmaceuticals, Inc. Substituted Tetracycline Compounds
WO2010006292A1 (en) * 2008-07-11 2010-01-14 Neumedics Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits
AP2011005631A0 (en) * 2008-09-19 2011-04-30 Paratek Pharmaceuticals Ind Tetracycline compounds for the treatment of rheumatoid arthritis and related methods of treatment.
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
EP3187484B1 (de) 2014-08-26 2019-02-06 Kao Corporation Verfahren zur herstellung einer zusammensetzung mit gereinigten chlorogensäuren
BR112019008897A2 (pt) 2016-11-01 2019-08-13 Paratek Pharm Innc método para tratar pneumonia bacteriana adquirida na comunidade.
CN113717073B (zh) * 2021-08-26 2023-11-14 河北圣雪大成制药有限责任公司 一种合成盐酸米诺环素的新方法
CN115028546A (zh) * 2022-08-12 2022-09-09 山东国邦药业有限公司 一种美他环素对甲苯磺酸盐氢化制备强力霉素磺基水杨酸盐的方法

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US26271A (en) * 1859-11-29 Berfthakd koegel
USRE26271E (en) 1967-09-26 Reductive alkylation process
US26253A (en) * 1859-11-29 Vegetable-cutter
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3036129A (en) * 1959-10-09 1962-05-22 American Cyanamid Co Preparation of 7-halo-6-deoxy-tetracyclines
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
FR1003M (fr) 1960-03-09 1961-12-18 Erba Carlo Spa Dérivés d'antibiotiques a base de tétracycline.
FR1430859A (de) 1960-05-23 1966-05-25
US3338963A (en) 1960-10-28 1967-08-29 American Cyanamid Co Tetracycline compounds
US3219671A (en) 1961-04-14 1965-11-23 American Cyanamid Co Substituted 6-deoxytetracyclines and 6-demethyl-6-deoxytetracyclines
US3239499A (en) * 1961-05-19 1966-03-08 Pfizer & Co C Tetracycline derivative
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3148212A (en) 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
USRE26253E (en) 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
ES302929A1 (es) 1964-08-07 1964-12-01 Viladot Oliva Francisco Procedimiento para la obtenciën de compuestos antibiëticos derivados de tetraciclina-penicilina
US3609188A (en) * 1964-10-29 1971-09-28 American Cyanamid Co 4-dedimethylamino-4-substituted-amino-6-demethyltetracyclines
US3345379A (en) 1965-02-26 1967-10-03 American Cyanamid Co 7-imidomethyl-6-demethyl-6-deoxytetracyclines
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
US3350557A (en) 1965-06-09 1967-10-31 Szymanski Ronald Fog lens attachments for vehicle headlights
US3397230A (en) 1966-03-14 1968-08-13 American Cyanamid Co Nitration of tetracyclines
US3341585A (en) * 1966-05-06 1967-09-12 American Cyanamid Co Substituted 7-and/or 9-amino-6-deoxytetracyclines
NL6607516A (de) 1966-05-31 1967-12-01
US3345410A (en) 1966-12-01 1967-10-03 American Cyanamid Co Substituted 7- and/or 9-amino tetracyclines
GB1206439A (en) * 1967-01-10 1970-09-23 American Cyanamid Co 7-substituted tetracyclines
US3403179A (en) 1967-01-10 1968-09-24 American Cyanamid Co Novel 7-(1, 2-bis-substituted-hydrazino)-tetracyclines and methods of preparing same
US3483251A (en) 1967-03-03 1969-12-09 American Cyanamid Co Reductive alkylation process
US3373196A (en) 1967-03-21 1968-03-12 American Cyanamid Co 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines
US3360561A (en) 1967-06-19 1967-12-26 American Cyanamid Co Nitration of tetracyclines
US3518306A (en) 1968-02-19 1970-06-30 American Cyanamid Co 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines
US3579579A (en) * 1968-04-18 1971-05-18 American Cyanamid Co Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
NL158172B (nl) * 1972-09-18 1978-10-16 Farmaceutici Italia Werkwijze voor het bereiden van tetracyclinederivaten met een substituent op de 7-plaats.
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
US3907889A (en) * 1973-06-18 1975-09-23 Abbott Lab Chelocardin derivatives
DE2527568A1 (de) * 1974-06-25 1976-01-15 Farmaceutici Italia Verfahren zur herstellung von alkyltetracyclinen und neue tetracyclinderivate
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
US5589470A (en) 1990-02-26 1996-12-31 Trustees Of Tufts College Reducing tetracycline resistance in living cells
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
DE69232302T4 (de) 1991-10-04 2003-02-13 American Cyanamid Co 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline
US5281628A (en) 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5284963A (en) 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
SG47520A1 (en) 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5248797A (en) 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
EP0745065A1 (de) 1994-02-17 1996-12-04 Pfizer Inc. 9-(substituiertes amino)-alpha-6-desoxy-5-oxytetracyclin derivate, deren herstellung und deren verwendung als antibiotika
US5574026A (en) * 1994-12-13 1996-11-12 American Cyanamid Company Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth
AU693013B2 (en) 1995-05-03 1998-06-18 Pfizer Inc. Novel tetracycline derivatives
CA2318580A1 (en) 1998-01-23 1999-07-29 Mark L. Nelson Pharmaceutically active compounds and methods of use thereof
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
EP2327686A3 (de) 1999-09-14 2012-08-22 Trustees Of Tufts College Verfahren zur Herstellung von substituierten Tetracyclinen mit Übergangschemien auf Metallbasis
WO2001052858A1 (en) 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
BR0109725A (pt) 2000-03-31 2003-02-04 Tufts College Composto de tetraciclina substituìdo, método para tratar um estado responsivo a tetraciclina em um mamìfero, composição farmacêutica, método para sintetizar um composto de tetraciclina 7- ou 9-substituìdo, e, intermediário reativo
AU2001259701A1 (en) 2000-05-15 2001-11-26 Paratek Pharmaceuticals, Inc 7-substituted fused ring tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020128238A1 (en) 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020128237A1 (en) 2000-06-16 2002-09-12 Nelson Mark L. 7-N-substituted phenyl tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
US20050143353A1 (en) 2000-07-07 2005-06-30 Paratek Pharmaceuticals, Inc. 13-Substituted methacycline compounds
BRPI0112269B8 (pt) 2000-07-07 2021-05-25 Paratek Pharm Innc composto de minociclina 9-aminometila substituída, e, composição farmacêutica
EP2166000A1 (de) 2000-07-07 2010-03-24 Trustees Of Tufts College 7-,8- und 9-substituierte Tetracyclin-Verbindungen
MXPA03000056A (es) 2000-07-07 2003-07-14 Tufts College Compuestos de tetraciclina sustituidos en posicion 7.
EP2298732A1 (de) * 2001-03-13 2011-03-23 Paratek Pharmaceuticals, Inc. 7, 9-substituierte Tetracyclin-Verbindungen
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
AU2002250331A1 (en) 2001-03-13 2002-09-24 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
CA2457234A1 (en) 2001-03-14 2002-09-19 Mark L. Nelson Substituted tetracycline compounds as antifungal agents
CA2440757A1 (en) 2001-03-14 2002-09-19 Michael Draper Substituted tetracycline compounds as synergistic antifungal agents
ATE455092T1 (de) 2001-04-24 2010-01-15 Paratek Pharm Innc Substituierte tetracyclin-verbindungen zur behandlung von malaria
US8088820B2 (en) 2001-04-24 2012-01-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for the treatment of malaria
EP2332549A1 (de) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Neue Tetracyclinverbindungen und deren medizinischen Anwendung
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
EP2311799A1 (de) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-Dedimethylamin-Tetracyclinverbindungen
CN1649582A (zh) 2002-03-08 2005-08-03 帕拉特克药品公司 氨基－甲基取代的四环素类化合物
WO2003079984A2 (en) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
JP4416652B2 (ja) * 2002-07-12 2010-02-17 パラテック ファーマシューティカルズ インコーポレイテッド ３、１０、および１２ａ置換されたテトラサイクリン化合物
CA2503446C (en) 2002-10-24 2012-12-18 Paratek Pharmaceuticals, Inc. Methods of using substituted tetracycline compounds to modulate rna
EP1656341A1 (de) 2003-07-09 2006-05-17 Paratek Pharmaceuticals, Inc. Prodrugs von 9-aminomethyltetracyclinverbindungen
CN1845897A (zh) * 2003-07-09 2006-10-11 帕拉特克药品公司 取代的四环素化合物
JP5010284B2 (ja) * 2004-01-15 2012-08-29 パラテック ファーマシューティカルズ インコーポレイテッド テトラサイクリン化合物の芳香族ａ環誘導体
WO2006047671A2 (en) * 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP2284164A3 (de) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituierte Tetracyclin-Verbindungen

Also Published As

Publication number Publication date
DE60027465D1 (de) 2006-05-24
CN1399627A (zh) 2003-02-26
AU7375600A (en) 2001-04-17
US6617318B1 (en) 2003-09-09
DE60027465T2 (de) 2007-02-01
EP2327687A2 (de) 2011-06-01
US7067681B2 (en) 2006-06-27
IL183125A0 (en) 2007-09-20
EP2327687A3 (de) 2012-08-15
US20060166946A1 (en) 2006-07-27
EA016099B1 (ru) 2012-02-28
US7696187B2 (en) 2010-04-13
AU2009225351A1 (en) 2009-11-05
CA2672722C (en) 2013-11-05
EP2327686A2 (de) 2011-06-01
CY1105094T1 (el) 2009-11-04
IL183124A0 (en) 2007-09-20
EP1666454A1 (de) 2006-06-07
JP2012031185A (ja) 2012-02-16
EP1666454B1 (de) 2011-09-07
US20040033996A1 (en) 2004-02-19
EA200400944A1 (ru) 2005-04-28
WO2001019784A1 (en) 2001-03-22
AU781439C (en) 2006-05-25
CN102336680A (zh) 2012-02-01
EP1240133A1 (de) 2002-09-18
EA200200366A1 (ru) 2002-10-31
HRP20020322A2 (en) 2004-02-29
AU2009225351B2 (en) 2012-04-12
DK1240133T3 (da) 2006-08-21
ATE323671T1 (de) 2006-05-15
EA012203B1 (ru) 2009-08-28
JP5093953B2 (ja) 2012-12-12
HUP0202798A3 (en) 2003-11-28
EA200900632A1 (ru) 2009-10-30
KR20020044141A (ko) 2002-06-14
EP2327686A3 (de) 2012-08-22
CA2383364C (en) 2009-11-17
CZ2002872A3 (cs) 2002-08-14
AU2005204259B2 (en) 2009-07-16
AU2005204259A1 (en) 2005-09-22
ES2260051T3 (es) 2006-11-01
MXPA02002595A (es) 2003-07-21
CA2383364A1 (en) 2001-03-22
IL148482A (en) 2010-12-30
CA2672722A1 (en) 2001-03-22
EP1666453A1 (de) 2006-06-07
AU781439B2 (en) 2005-05-26
JP2003509404A (ja) 2003-03-11
PT1240133E (pt) 2006-07-31
BR0013993A (pt) 2002-07-02
EP1240133B1 (de) 2006-04-19
KR100764992B1 (ko) 2007-10-09
HRP20020322B1 (en) 2009-04-30
IL183124A (en) 2012-05-31
CZ301835B6 (cs) 2010-07-07
IL148482A0 (en) 2002-09-12
HUP0202798A2 (hu) 2002-12-28
EA005118B1 (ru) 2004-10-28

Similar Documents

Publication Publication Date Title
ATE523485T1 (de) Verfahren zur herstellung von substituierten tetracyclinen mit hilfe von auf übergangsmetalle basierten chemikalien
ES2353826T5 (es) Procesos para isomerización geométrica de olefinas halogenadas
DE69423231T2 (de) Verfahren mit hoher produktivität zur herstellung von niederen olefinen durch katalytische umwandlung
ATE248815T1 (de) Verfahren zur herstellung einer wässrigen monoester percarbonsäurelösung
DE69809021T2 (de) Verfahren zur Herstellung eines formselektiven, metall-enthaltenden Katalysators; seine Verwendung in der Umwandlung von Kohlenwasserstoffen
ATE470682T1 (de) Verfahren zur herstellung von geträgerten übergangsmetallpolymerisationskatalysatoren und daraus gebildete zusammensetzungen
KR950032064A (ko) 5-포르밀발러레이트의 제조방법
DE69818192D1 (de) Katalysator für Teiloxidation von einem Kohlenwasserstoff und Verfahren zur Herstellung einer Sauerstoff enthaltenden organischen Verbindung
ATE410409T1 (de) Verfahren zur herstellung von gesättigten nitrilen
ATE403682T1 (de) Herstellung von katalysatorsystemen
DE20116723U1 (de) Amlodipinderivate und Vorstufe davon
WO2003079983A3 (en) Methods of preparing substituted tetracyclines with transition metal-based chemistries
ATE230713T1 (de) Verfahren zur herstellung von kohlenwasserstoffen mit hoher oktanzahl durch selektiven dimerizierung von isobuten
DE69721027D1 (de) Verfahren zur herstellung von substituierten aromatischen aminoverbindungen
DE60039922D1 (de) Abgasreinigende katalysatorverbindung, diese verbindung enthaltender katalysator und verfahren zur herstellung der verbindung
ATE286019T1 (de) Prozess zur herstellung einer aromatischen verbindung, welche mit einem tertiären nitril substituiert ist
DK1187669T3 (da) Fremgangsmåde til katalytisk oxidation af flygtige organiske forbindelser
Bhogadhi et al. Formation of γ-Keto Esters from β-Keto Esters: Methyl 5, 5-dimethyl-4-oxohexanoate
DE10347439A1 (de) Verfahren zur Herstellung von aromatischen Aminen durch heterogen katalysierte Hydrierung
ATE435699T1 (de) Katalysatorvorläufer zur herstellung von olefinen mit ungerader kohlenstoffzahl, herstellungsverfahren dafür und verfahren zur herstellung derartiger olefine
DE50309092D1 (de) Verfahren zur herstellung von palladium(0)-haltigen verbindungen
EP1101754A3 (de) Verfahren zur Reduktion der Menge an schwefelhältigen Nitrifikationshemmern
EP0665241A3 (de) Einstufenverfahren zur Herstellung von Polyisobutylen-Carbonsäuren
TH63679A (th) ฟอสฟอไนท์ ลิแกนด์ และการใช้มันในไฮโดรไชยาเนชั่น
DE60332247D1 (de) Verfahren zur herstellung von fluoriertem benzonitril

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties