AU2003218242A1 - Methods of preparing substituted tetracyclines with transition metal-based chemistries - Google Patents

Methods of preparing substituted tetracyclines with transition metal-based chemistries

Info

Publication number
AU2003218242A1
AU2003218242A1 AU2003218242A AU2003218242A AU2003218242A1 AU 2003218242 A1 AU2003218242 A1 AU 2003218242A1 AU 2003218242 A AU2003218242 A AU 2003218242A AU 2003218242 A AU2003218242 A AU 2003218242A AU 2003218242 A1 AU2003218242 A1 AU 2003218242A1
Authority
AU
Australia
Prior art keywords
methods
transition metal
preparing substituted
based chemistries
substituted tetracyclines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003218242A
Other versions
AU2003218242A8 (en
Inventor
Darrell J. Koza
Mark L. Nelson
Glen Rennie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tufts University
Original Assignee
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts University filed Critical Tufts University
Publication of AU2003218242A8 publication Critical patent/AU2003218242A8/en
Publication of AU2003218242A1 publication Critical patent/AU2003218242A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
AU2003218242A 2002-03-21 2003-03-18 Methods of preparing substituted tetracyclines with transition metal-based chemistries Abandoned AU2003218242A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36705002P 2002-03-21 2002-03-21
US60/367,050 2002-03-21
PCT/US2003/008323 WO2003079983A2 (en) 2002-03-21 2003-03-18 Methods of preparing substituted tetracyclines with transition metal-based chemistries

Publications (2)

Publication Number Publication Date
AU2003218242A8 AU2003218242A8 (en) 2003-10-08
AU2003218242A1 true AU2003218242A1 (en) 2003-10-08

Family

ID=28454832

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003218242A Abandoned AU2003218242A1 (en) 2002-03-21 2003-03-18 Methods of preparing substituted tetracyclines with transition metal-based chemistries

Country Status (2)

Country Link
AU (1) AU2003218242A1 (en)
WO (1) WO2003079983A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1716101A1 (en) 2004-01-15 2006-11-02 Paratek Pharmaceuticals, Inc. Aromatic a-ring derivatives of tetracycline compounds
EP2301912A3 (en) 2004-10-25 2012-07-11 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
EP2295419A3 (en) * 2004-10-25 2011-09-21 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
CN101489987A (en) * 2006-04-17 2009-07-22 特瓦制药工业有限公司 Isolation of tetracycline derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0202798A3 (en) * 1999-09-14 2003-11-28 Trustees Of Tufts College Medf Methods of preparing substituted tetracyclines with transition metal-based reactions
KR100997596B1 (en) * 2000-07-07 2010-11-30 파라테크 파마슈티컬스, 인크. 7-substituted tetracycline compounds
MXPA03000055A (en) * 2000-07-07 2003-07-14 Tufts College 9-substituted minocycline compounds.

Also Published As

Publication number Publication date
WO2003079983A3 (en) 2004-11-11
AU2003218242A8 (en) 2003-10-08
WO2003079983A2 (en) 2003-10-02

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase