IL148482A0 - Methods of preparing substituted tetracyclines with transition metal-based chemistries - Google Patents

Methods of preparing substituted tetracyclines with transition metal-based chemistries

Info

Publication number
IL148482A0
IL148482A0 IL14848200A IL14848200A IL148482A0 IL 148482 A0 IL148482 A0 IL 148482A0 IL 14848200 A IL14848200 A IL 14848200A IL 14848200 A IL14848200 A IL 14848200A IL 148482 A0 IL148482 A0 IL 148482A0
Authority
IL
Israel
Prior art keywords
tetracycline
substituted
compounds
transition metal
reactive
Prior art date
Application number
IL14848200A
Other languages
English (en)
Original Assignee
Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College filed Critical Tufts College
Publication of IL148482A0 publication Critical patent/IL148482A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IL14848200A 1999-09-14 2000-09-13 Methods of preparing substituted tetracyclines with transition metal-based chemistries IL148482A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15470199P 1999-09-14 1999-09-14
US23209100P 2000-09-12 2000-09-12
PCT/US2000/025040 WO2001019784A1 (en) 1999-09-14 2000-09-13 Methods of preparing substituted tetracyclines with transition metal-based chemistries

Publications (1)

Publication Number Publication Date
IL148482A0 true IL148482A0 (en) 2002-09-12

Family

ID=26851695

Family Applications (4)

Application Number Title Priority Date Filing Date
IL14848200A IL148482A0 (en) 1999-09-14 2000-09-13 Methods of preparing substituted tetracyclines with transition metal-based chemistries
IL148482A IL148482A (en) 1999-09-14 2002-03-04 Methods of preparing substituted tetracyclines with transition metal-based chemistries, some such novel compounds and use thereof in the preparation of medicaments
IL183125A IL183125A0 (en) 1999-09-14 2007-05-10 Methods of preparing substituted tetracyclines with transition metal-based chemistries, some such novel compounds and use thereof in the preparation of medicaments
IL183124A IL183124A (en) 1999-09-14 2007-05-10 9-Metamorphic Tetric Compound and Use of Metamorphic 9-Metric Compound in Preparation

Family Applications After (3)

Application Number Title Priority Date Filing Date
IL148482A IL148482A (en) 1999-09-14 2002-03-04 Methods of preparing substituted tetracyclines with transition metal-based chemistries, some such novel compounds and use thereof in the preparation of medicaments
IL183125A IL183125A0 (en) 1999-09-14 2007-05-10 Methods of preparing substituted tetracyclines with transition metal-based chemistries, some such novel compounds and use thereof in the preparation of medicaments
IL183124A IL183124A (en) 1999-09-14 2007-05-10 9-Metamorphic Tetric Compound and Use of Metamorphic 9-Metric Compound in Preparation

Country Status (21)

Country Link
US (3) US6617318B1 (xx)
EP (5) EP1666453A1 (xx)
JP (2) JP5093953B2 (xx)
KR (1) KR100764992B1 (xx)
CN (2) CN1399627A (xx)
AT (2) ATE323671T1 (xx)
AU (3) AU781439C (xx)
BR (1) BR0013993A (xx)
CA (2) CA2383364C (xx)
CY (1) CY1105094T1 (xx)
CZ (1) CZ301835B6 (xx)
DE (1) DE60027465T2 (xx)
DK (1) DK1240133T3 (xx)
EA (3) EA012203B1 (xx)
ES (1) ES2260051T3 (xx)
HR (1) HRP20020322B1 (xx)
HU (1) HUP0202798A3 (xx)
IL (4) IL148482A0 (xx)
MX (1) MXPA02002595A (xx)
PT (1) PT1240133E (xx)
WO (1) WO2001019784A1 (xx)

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US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
JP2002501026A (ja) * 1998-01-23 2002-01-15 トルスティーズ オブ トゥフツ カレッジ 薬学的に活性の化合物及びその利用法
EP1666453A1 (en) * 1999-09-14 2006-06-07 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
WO2001052858A1 (en) * 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
US6818634B2 (en) * 2000-03-31 2004-11-16 Paratek Pharmaceuticals, Inc. 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
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US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
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WO2002004405A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 13-substituted methacycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
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US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
US8486921B2 (en) * 2006-04-07 2013-07-16 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
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