ATE526308T1 - 13-substituierte methacyclinverbindungen - Google Patents

13-substituierte methacyclinverbindungen

Info

Publication number
ATE526308T1
ATE526308T1 AT10160000T AT10160000T ATE526308T1 AT E526308 T1 ATE526308 T1 AT E526308T1 AT 10160000 T AT10160000 T AT 10160000T AT 10160000 T AT10160000 T AT 10160000T AT E526308 T1 ATE526308 T1 AT E526308T1
Authority
AT
Austria
Prior art keywords
compounds
substituted methacycline
methacycline compounds
substituted
methods
Prior art date
Application number
AT10160000T
Other languages
English (en)
Inventor
Mark L Nelson
Laura Mcintyre
Glen Rennie
Beena Bhatia
Original Assignee
Tufts College
Paratek Pharm Innc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tufts College, Paratek Pharm Innc filed Critical Tufts College
Application granted granted Critical
Publication of ATE526308T1 publication Critical patent/ATE526308T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT10160000T 2000-07-07 2001-06-29 13-substituierte methacyclinverbindungen ATE526308T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21658000P 2000-07-07 2000-07-07

Publications (1)

Publication Number Publication Date
ATE526308T1 true ATE526308T1 (de) 2011-10-15

Family

ID=22807633

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05020365T ATE465989T1 (de) 2000-07-07 2001-06-29 13-substituierte methacyclinverbindungen
AT10160000T ATE526308T1 (de) 2000-07-07 2001-06-29 13-substituierte methacyclinverbindungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05020365T ATE465989T1 (de) 2000-07-07 2001-06-29 13-substituierte methacyclinverbindungen

Country Status (16)

Country Link
EP (3) EP1661883B1 (de)
JP (1) JP2004502751A (de)
KR (1) KR20030017609A (de)
CN (1) CN1452611A (de)
AT (2) ATE465989T1 (de)
AU (1) AU2001271616A1 (de)
BR (1) BR0112268A (de)
CA (1) CA2415172A1 (de)
CZ (1) CZ2003332A3 (de)
DE (1) DE60141994D1 (de)
EA (1) EA200300136A1 (de)
HR (1) HRP20030092A2 (de)
HU (1) HUP0301429A2 (de)
IL (1) IL153674A0 (de)
MX (1) MXPA03000036A (de)
WO (1) WO2002004405A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1716101A1 (de) 2004-01-15 2006-11-02 Paratek Pharmaceuticals, Inc. Derivate von tetracyclinverbindungen mit aromatischem a-ring
EP2301916A3 (de) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-Aminotetracycline und Verfahren zu ihrer Verwendung
CN101967108B (zh) * 2010-09-13 2013-06-19 苏春华 一种美他环素的衍生物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990331A (en) 1956-11-23 1961-06-27 Pfizer & Co C Stable solutions of salts of tetracyclines for parenteral administration
US2980584A (en) 1957-10-29 1961-04-18 Pfizer & Co C Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation
US3062717A (en) 1958-12-11 1962-11-06 Pfizer & Co C Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation
US3165531A (en) 1962-03-08 1965-01-12 Pfizer & Co C 13-substituted-6-deoxytetracyclines and process utilizing the same
US3183267A (en) * 1962-09-06 1965-05-11 Pfizer & Co C 6-methylenetetracycline derivatives
GB1108310A (en) * 1964-04-30 1968-04-03 Pfizer & Co C Derivatives of 6-methylene-tetracycline and process for their preparation
US3454697A (en) 1965-06-08 1969-07-08 American Cyanamid Co Tetracycline antibiotic compositions for oral use
NL6607516A (de) 1966-05-31 1967-12-01
DE1767891C3 (de) 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
US3957980A (en) 1972-10-26 1976-05-18 Pfizer Inc. Doxycycline parenteral compositions
DE2442829A1 (de) 1974-09-06 1976-03-18 Merck Patent Gmbh Tetracyclische verbindungen und verfahren zu ihrer herstellung
US4018889A (en) 1976-01-02 1977-04-19 Pfizer Inc. Oxytetracycline compositions
US4126680A (en) 1977-04-27 1978-11-21 Pfizer Inc. Tetracycline antibiotic compositions
CA2672722C (en) 1999-09-14 2013-11-05 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries

Also Published As

Publication number Publication date
ATE465989T1 (de) 2010-05-15
EP1661883A1 (de) 2006-05-31
JP2004502751A (ja) 2004-01-29
MXPA03000036A (es) 2003-07-14
EA200300136A1 (ru) 2003-06-26
EP1301465A2 (de) 2003-04-16
EP2204361B1 (de) 2011-09-28
HUP0301429A2 (hu) 2003-09-29
KR20030017609A (ko) 2003-03-03
DE60141994D1 (de) 2010-06-10
CN1452611A (zh) 2003-10-29
IL153674A0 (en) 2003-07-06
EP2204361A1 (de) 2010-07-07
AU2001271616A1 (en) 2002-01-21
CZ2003332A3 (cs) 2003-05-14
WO2002004405A3 (en) 2002-03-14
HRP20030092A2 (en) 2004-06-30
WO2002004405A2 (en) 2002-01-17
BR0112268A (pt) 2003-05-27
CA2415172A1 (en) 2002-01-17
EP1661883B1 (de) 2010-04-28

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties